Results 101 to 110 of about 5,352 (196)

Synaptopodin, podocin, and nephrin are significantly downregulated in diabetic nephropathy (DN) as compared to controls (Con).

, 2013
Representative staining of synaptopodin in Con (A), DN (B), podocin in Con (E) and DN (F), and nephrin in Con (I) and DN (J). Negative controls without administration of primary antibody are represented for synaptopodin (C), podocin (G), and nephrin (K).
Ying Fan (187798), Hillel W. Cohen (232205), David B. Thomas (266446), Mythili Ghanta (322600), John Cijiang He (322606), Maria Abadi (322604), Andi Qipo (165108), Peter Y. Chuang (322602), Belinda Jim (322598)   +8 more
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肥胖患者肾小球Podocin的表达减少及临床意义

Zhongguo shiyan zhenduanxue, 2012
目的检测肥胖患者肾小球足细胞上Podocin的蛋白分布和表达,探讨Podocin在肥胖导致蛋白尿中的变化及意义。方法收集肾脏切除病理标本,取其相对正常肾脏皮质,体重指数(BMI)≥28kg/m2者16例作为肥胖组(Ob组 ...
杜娟, 朱安峰, 宋东明, 马洪喜, 马俐儒, 魏立晶   +5 more
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Genipin restores the expression of podocin and WT1 in diabetic mice.

, 2013
(a) Western blot analysis shows the results of podocin and WT1 in the kidneys of each group. The samples were reprobed with actin to confirm equal loading of each lane. Representative pictures show the results of three animals per group.
Yang Zhou (65942), Wenjing Qiu (315272), Chen-yu Zhang (5652109), Li Fang (315274), Ruoyun Tan (315278), Junwei Yang (112231), Weifang Su (315276), Lei Jiang (73366), Xiao Han (102316), Lu Chen (75170)   +9 more
core   +1 more source

The Correlation of MicroRNA-21 With the Nephrin, Podocin, and Urinary Albumin-Creatinine Ratio in Patients With Type 2 Diabetes and Albuminuria: A Cross-Sectional Study

Canadian Journal of Kidney Health and Disease
Background: Diabetic kidney disease (DKD) is the most common and deranging microvascular complication of diabetes mellitus (DM). Podocytopathy is a key component of glomerular damage in DKD. Micro RNA-21 (miRNA-21) is an epigenetic regulator that plays a
Pringgodigdo Nugroho, Tri Hadi Susanto, Maruhum Bonar, Aulia Rizka, Aida Lydia, Soekamto Koesno, Pradana Soewondo, Hamzah Shatri, Carissa Cornelia Chundiawan, Fidel Hermanto   +9 more
doaj   +1 more source

Identification of Proteins That Interact with Podocin Using the Yeast 2-Hybrid System

Yonsei Medical Journal, 2009
As a membrane protein at the insertion site of the slit diaphragm (SD) complex in podocyte foot processes, podocin has been reported to act as a scaffolding protein required to maintain or regulate the structural integrity of the SD. In order to identify proteins that associate or interact with podocin, we screened a mouse kidney complementary DNA ...
Park, Soo Jin, Lee, Byung Ha, Kim, Dae Joong   +2 more
openaire   +2 more sources

A Disease-causing Mutation Illuminates the Protein Membrane Topology of the Kidney-expressed Prohibitin Homology (PHB) Domain Protein Podocin

, 2014
Background: Mutations in the stomatin family protein podocin are the most common genetic cause of proteinuria. Results: A conserved proline residue of podocin is essential for its membrane topology.
Benzing, Thomas, Lamkemeyer, Tobias, Kratz, John E., Kunzelmann, Karl, Chalfie, Martin, Sirianant, Lalida, Schurek, Eva-Maria, Tax, Judit, Ungrue, Denise, Schermer, Bernhard, Höhne, Martin, Völker, Linus A., Rinschen, Markus M.   +12 more
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An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms.

PLoS ONE, 2009
Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus.
Tomonori Hirose, Daisuke Satoh, Hidetake Kurihara, Chiho Kusaka, Hiroko Hirose, Kazunori Akimoto, Taiji Matsusaka, Iekuni Ichikawa, Tetsuo Noda, Shigeo Ohno   +9 more
doaj   +1 more source

Podocin and MEC-2 recruit cholesterol of the plasmamembrane to organize lipid-protein-supercomplexes : the role of palmitoylated podocin in cholesterol-recruitment

, 2007
Glomeruläre Erkrankungen gehören zu den häufigsten Nierenerkrankungen überhaupt. Mutation des NPHS2-Gens gilt dabei als häufigste genetische Ursache des nephrotischen Syndroms und der steroid-refraktären FSGS überhaupt.
Hagmann, Hanns Henning
core  

Analysis of nephrin and podocin renal protein expression.

, 2015
(A) Nephrin. (B) Podocin. Data are means ± SEM. NS: normal salt diet. LS: low salt diet.
Renato de Oliveira Crajoinas (817745), Paula Frizera Vassallo (585074), Flávia Letícia Martins (817747), Isabella Binotti Araújo (817749), Breno Valentim Nogueira (817748), Rebeca Caldeira Machado Berger (817744), Marilene Luzia Oliveira (817746), Daisy Motta-Santos (483618), José Geraldo Mill (595356), Robson Augusto Souza Santos (817750), Ludimila Forechi (290219), Adriana Castello Costa Girardi (592473)   +11 more
core   +1 more source

厄贝沙坦对早期糖尿病肾脏疾病大鼠足细胞nephrin和podocin表达的影响

Linchuang shenzangbing zazhi, 2014
目的 观察厄贝沙坦（irbesartan）对糖尿病肾脏疾病（diabetic kidney disease,DKD）大鼠足细胞裂孔隔膜蛋白分子（nephrin和podocin）表达的影响,探讨厄贝沙坦对DKD的防治作用。方法 以高脂高糖喂养8周联合小剂量链脲佐菌素（30 rmg/kg）建立DKD大鼠模型,将DKD大鼠模型随机分为2组:厄贝沙坦组及模型对照组;另设正常对照组。厄贝沙坦组给予厄旦沙坦(50 mg·kg-1·d-1),另外2组每日给予等量0.9%生理盐水灌胃。各组于治疗前及药物干预后第4、8 ...
岳少姮
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