Results 81 to 90 of about 5,352 (196)

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, Volume 13, Issue 9, 13 February 2026.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

槲皮素对糖尿病大鼠肾脏足细胞nephrin和podocin表达的影响

Zhongguo shiyan zhenduanxue, 2019
目的探讨槲皮素对糖尿病大鼠肾脏足细胞nephrin和podocin表达的影响。方法采用腹腔注射链脲佐菌素(STZ)方法构建糖尿病大鼠模型,分为正常对照组、糖尿病模型组、槲皮素给药组。12周后测定肾脏指数、血肌酐、尿素水平及24h尿中总蛋白、白蛋白、肌酐、尿素水平;Western blot方法检测肾皮质nephrin和podocin的蛋白表达。结果槲皮素给药组肾脏指数、血肌酐和尿素水平低于糖尿病模型组;槲皮素给药组尿中总蛋白、白蛋白水平明显低于糖尿病组,尿中肌酐、尿素水平高于糖尿病组 ...
靳英丽, 屈智慧, 杨盼盼, 袁渤雨, 陈丽波   +4 more
doaj  

Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes [PDF]

Journal of the American Society of Nephrology, 2011
Podocytes do not remain fully differentiated when cultured, and they are difficult to image in vivo, making the study of podocyte biology challenging. Zebrafish embryos are transparent and develop a single, midline, pronephric glomerulus accessible for imaging and systematic functional analysis.
Bing, He, Lwaki, Ebarasi, Kjell, Hultenby, Karl, Tryggvason, Christer, Betsholtz   +4 more
openaire   +2 more sources

Heparanase inhibition prevents glycocalyx damage and albuminuria in experimental minimal change disease

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Michael Crompton, Raina D. Ramnath, Kai Betteridge, Sara Desideri, Aldara Martin Alonso, Lulu Jiang, Monica Gamez, Holly Stowell‐Connolly, Viktoriia Vasylchenko, Karen L. Onions, Matthew J. Butler, Chris R. Neal, Andrew H. J. Salmon, Jeremy E. Turnbull, Hiroshi Kawachi, Olga V. Zubkova, Gavin I. Welsh, Simon C. Satchell, Rebecca R. Foster   +18 more
wiley   +1 more source

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu, Ming‐Fo Hsu, Yoshihiro Ito, Suh‐Yuen Liang, Kwan‐Liu Ma, Tzu‐Ching Meng, Fawaz G. Haj   +6 more
wiley   +1 more source

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Rosmarinic acid monotherapy is better than the combination of rosmarinic acid and telmisartan in preventing podocyte detachment and inhibiting the progression of diabetic nephropathy in rats

Biologics: Targets & Therapy, 2019
Nur Samsu,1 Setyawati Soeharto,2 Muhaimin Rifai,3 Achmad Rudijanto41Department of Internal Medicine, Division of Nephrology and Hypertension, Faculty of Medicine; 2Department of Pharmacology, Faculty of Medicine; 3Department of Biology, Faculty of ...
Samsu N, Soeharto S, Rifai M, Rudijanto A   +3 more
doaj  

Correlation study of podocyte injur y and kidney function in patients with acute kidney injur y

Journal of Acute Disease, 2016
Objective: To investigate the correlation between the podocyte injury indexes in urine such as nephrin, desmin, P-cadherin, podocin, podocalyxin and CD2-associated protein (CD2AP) and the kidney function in patients with acute kidney injury (AKI ...
You-Gang Feng, Bo Liang, Jun Liu, Ming-Dong Jiang, Hong-Jian Liu, Yi-Qiang Huang, Lu Xiao   +6 more
doaj   +1 more source

Pengaruh Pemberian Silybin dan Telmisartan Terhadap Kadar Podocin Urin Tikus Diabetes

, 2022
LATAR BELAKANG: Nefropati diabetik (ND) merupakan komplikasi diabetes melitus (DM) yang serius dan menjadi penyebab utama penyakit ginjal kronis (PGK). Hiperglikemia kronik memicu stres oksidatif dan mengaktivasi sistem renin-angiotensin-aldosteron (SRAA)
dr. Rulli Rosandi, Sp.PD, K-EMD, Dr. dr. Nur Samsu, Sp.PD, K-GH, Ikkeputri, Adhityari   +2 more
core  

Protein and mRNA expression of Nephrin and Podocin in renal cortex after the intraperitoneal injection of LPS.

, 2023
(A)–(B) mRNA expression of Nephrin and Podocin. (C)–(D) Protein expression of Nephrin and Podocin. The data were shown as mean ± S.E.M., # and ##, compared with normal groups, P P P < 0.05. NS: no significance.
Song Xu (187853), Hong Sun (132232), Jun Li (6494), Yulin Feng (117705), Qin Gong (118801), Tianyu Huang (2007169), Mulan Wang (9533134), Chenliang Zha (16618100), Dong Yu (153717)   +8 more
core   +1 more source