Results 71 to 80 of about 5,352 (196)

Podocin and uPAR are good biomarkers in cases of Focal and segmental glomerulosclerosis in pediatric renal biopsies.

PLoS ONE, 2019
There are controversies whether Minimal Change Disease (MCD) and Focal and Segmental Glomerulosclerosis (FSGS) are distinct glomerular lesions or different manifestations within the same spectrum of diseases.
Lívia Helena de Morais Pereira, Crislaine Aparecida da Silva, Maria Luíza Gonçalves Dos Reis Monteiro, Liliane Silvano Araújo, Laura Penna Rocha, Marcelo Bernardes da Rocha Reis, Fernando Silva Ramalho, Rosana Rosa Miranda Corrêa, Marcos Vinicius Silva, Marlene Antonia Reis, Juliana Reis Machado   +10 more
doaj   +1 more source

Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach

Frontiers in Medicine, 2018
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine.
Samuel Mon-Wei Yu, Pitchaphon Nissaisorakarn, Irma Husain, Belinda Jim, Belinda Jim   +4 more
doaj   +1 more source

Evolutionary conservation of intrinsically unstructured regions in slit-diaphragm proteins.

PLoS ONE, 2021
Vertebrate kidneys contribute to homeostasis by regulating electrolyte, acid-base balance, removing toxic metabolites from blood, and preventing protein loss into the urine.
Sandeep K N Mulukala, Vaishnavi Kambhampati, Abrar H Qadri, Anil K Pasupulati   +3 more
doaj   +1 more source

Maternal Ethanol Exposure Impairs the Kidney of Offspring by Alteration of Podocyte Proteins Genes Expression and Fibrosis

Journal of Kerman University of Medical Sciences, 2022
Background: This study examined the effect of prenatal and early postnatal ethanol exposure on the structural, functional, and molecular alterations of rat’s offspring kidney on postnatal days 21 and 90.
Farideh Nezami Majd, Alireza Shirpoor, Ali Taghizadeh Afshari , Fatemeh Kheradmand , Roya Naderi , Masoumeh Pourjabali, Yousef Rasmi   +6 more
doaj   +1 more source

Rare Functional Variants of Podocin (NPHS2) Promoter in Patients With Nephrotic Syndrome

Gene Expression, 2006
Podocin (NPHS2) is a component of the glomerular slit-diaphragm, with major regulatory functions in renal permeability of proteins. Loss of podocin and decrease in resynthesis may influence the outcome of proteinuric renal disease such as segmental glomerulosclerosis (FSGS), and promoter functionality plays a key role in this process.
OLEGGINI R, BERTELLI R, DI DONATO A, DI DUCA M, CARIDI G, SANNA CHERCHI S, SCOLARI, Francesco, MURER L, ALLEGRI L, COPPO R, EMMA F, CAMUSSI G, PERFUMO F, GHIGGERI GM   +13 more
openaire   +4 more sources

NPHS2 (Podocin) Mutations in Nephrotic Syndrome. Clinical Spectrum and Fine Mechanisms [PDF]

Pediatric Research, 2005
Nephrotic syndrome (NS) is the most frequent cause of proteinuria in children and is emerging as a leading cause of uremia. Molecular studies in families with recessive NS have led to the discovery of specialized molecules endowed in podocytes that play a role in proteinuria.
Caridi, Gianluca, Perfumo, Francesco, Ghiggeri, Gian Marco   +2 more
openaire   +3 more sources

Specific podocin mutations determine age of onset of nephrotic syndrome all the way into adult life

, 2009
In steroid-resistant nephrotic syndrome (SRNS) Machuca et al. report that mutations of the recessive podocin gene cause adult-onset SRNS if the R229Q genetic variant occurs in a compound heterozygous state with another podocin mutation.
Hildebrandt, Friedhelm, Heeringa, Saskia F.   +1 more
core   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Correlation of nephrin and podocin expression in patients of control, MCD and FSGS groups.

, 2019
Correlation between (A) percentage in nephrin area and percentage in podocin area in control patients, (B) percentage in nephrin area and percentage in podocin area in patients in MCD group, (C) percentage in nephrin area and percentage in podocin area ...
Maria Luíza Gonçalves dos Reis Monteiro (6403412), Liliane Silvano Araújo (6403415), Fernando Silva Ramalho (6832157), Marcos Vinicius Silva (4680826), Marlene Antonia Reis (6832163), Rosana Rosa Miranda Corrêa (6832160), Juliana Reis Machado (4748310), Lívia Helena de Morais Pereira (6832148), Marcelo Bernardes da Rocha Reis (6832154), Crislaine Aparecida da Silva (4748319), Laura Penna Rocha (6832151)   +10 more
core   +1 more source

A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome

, 2023
Podocin is a key membrane scaffolding protein of the kidney podocyte essential for intact glomerular filtration. Mutations in NPHS2, the podocin-encoding gene, represent the commonest form of inherited nephrotic syndrome (NS), with early, intractable ...
Ding, Wen Y, Tuffin, Jack, Pranke, Iwona, Welsh, Gavin I, Kuzmuk, Valeryia, Butler, Matthew, Coward, Richard J, Saleem, Moin A, Rollason, Ruth, Beesley, Matthew, Mollet, Géraldine, Waters, Aoife M, Sessions, Richard, Antignac, Corinne, Foster, Rebecca R, Edelman, Aleksander   +15 more
core   +1 more source