Results 51 to 60 of about 5,352 (196)
Frontiers in Physiology, 2021 This study aimed to investigate the antiproteinuric and hyperkalemic mechanisms activated by dual renin-angiotensin system (RAS) blockade in renovascular hypertensive rats (2-kidney 1-clip model [2K-1C]). Six weeks after clipping the left renal artery or
José Wilson N. Corrêa +8 more
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Molecular Mechanisms of Proteinuria in Focal Segmental Glomerulosclerosis
Frontiers in Medicine, 2018 Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular disease resulting in end-stage renal disease in the USA and is increasing in prevalence worldwide.
Yumeng Wen, Sapna Shah, Kirk N. Campbell
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Biomarkers of Kidney Disease in Horses: A Review of the Current Literature
Animals, 2022 Creatinine only allows detection of kidney disease when 60 to 75% of the glomerular function is lost and is therefore not an ideal marker of disease. Additional biomarkers could be beneficial to assess kidney function and disease.
Gaby van Galen +2 more
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mRNA Expression of Podocyte Associated Proteins in Peripheral Blood Mononuclear Cells of Type 2 Diabetes Mellitus Patients with and without Nephropathy [PDF]
Journal of Krishna Institute of Medical Sciences University, 2020 Background: Diabetic nephropathy is the leading cause of End-Stage Renal Disease (ESRD) emerging in developed as well as developing countries, with the complicated pathogenesis.
Gouri M. Bhoite +4 more
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CASE OF NON-SEVERE CONGENITAL NEPHROTIC SYNDROME
Педиатрическая фармакология, 2014 Nephrotic syndrome is a severe renal disease that may result in the end-stage renal failure despite the extent of proteinuria. Prognosis and tactics of therapy of nephrotic syndrome depend both on the morphological diagnosis and on the cause of the ...
I. S. Kostushina +6 more
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Containing anti-PLA2R IgG antibody induces podocyte injury in idiopathic membranous nephropathy
Renal Failure, 2023 Background Idiopathic membranous nephropathy is widely recognized as an autoimmune kidney disease that is accompanied by the discovery of several autoantibodies, and the antibody subclass in the circulation of patients with iMN is mainly IgG.
Ying Zhang +8 more
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Reduction of podocin expression.
, 2013 Western blot analysis of podocytes showing a lower expression of podocin with increasing concentrations (0-100 nM) of EVL and SRL after 48 h of incubation, respectively (A, B); no differences in podocin expression analyzing EVL and SRL (20 nM) in ...
Lars P. Kihm (485769) +6 more
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Characterization of a short isoform of the kidney protein podocin in human kidney [PDF]
BMC Nephrology, 2013 Abstract Background Steroid resistant nephrotic syndrome is a severe hereditary disease often caused by mutations in the NPHS2 gene. This gene encodes the lipid binding protein podocin which localizes to the slit diaphragm of podocytes and is essential for the maintenance of an intact glomerular filtration barrier ...
Völker, Linus A. +9 more
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PodocinTVV339,340,341 regulates the turnover of podocin through a lipid raft-independent mechanism.
, 2013 A. Differentiated podocytes stably expressing Flag-tagged podocin, podocin1–285 or podocinTVV339,340,341AAA were exposed to the translation inhibitor cycloheximide for the times as indicated and analyzed per western blot using anti-Flag antibody (a ...
Markus Gödel (152664) +4 more
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The domain podocin340–350 regulates the subcellular localization of podocin.
, 2013 A–D. Various truncations of Flag-tagged podocin were coexpressed with eGfp-tagged CD63 in HeLa-cells. Immunofluorescence using anti-Flag antibody revealed a primarily membranous staining pattern for podocin1–285 and podocin1–340 (a and b).
Markus Gödel (152664) +4 more
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