Results 41 to 50 of about 5,352 (196)

Ameliorative effects of glycine on cobalt chloride‐induced hepato‐renal toxicity in rats

Animal Models and Experimental Medicine, 2023
Background The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride (CoCl2). This study was designed to investigate the role of
Oluwafikemi Temitayo Iji, Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Omolola Victoria Awoyomi, Ademola Adetokunbo Oyagbemi, Moses Olusola Adetona, Temidayo Olutayo Omobowale, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju, Evaristus Nwulia   +9 more
doaj   +1 more source

Cloning of Rat Homologue of Podocin [PDF]

Journal of the American Society of Nephrology, 2003
Podocin is identified as a product of the gene mutated in a patient with autosomal recessive steroid-resistant nephrotic syndrome. Although podocin is reported to be located at the slit diaphragm area, the precise role of podocin for maintaining the barrier function of the slit diaphragm has not been clearly elucidated.
Hiroshi, Kawachi, Hiroko, Koike, Hidetake, Kurihara, Tatsuo, Sakai, Fujio, Shimizu   +4 more
openaire   +2 more sources

Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes [PDF]

Journal of the American Society of Nephrology, 2014
Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. Mutations in the human podocin gene NPHS2 cause familial or sporadic forms of renal disease owing to the disruption of filtration barrier integrity.
He, B, Ebarasi, L, Zhao, Z, Guo, J, Ojala, JR, Hultenby, K, De Val, S, Betsholtz, C, Tryggvason, K   +8 more
openaire   +2 more sources

Elevated Levels of Urinary Podocyte-Derived Microparticles in Nephrotic Syndrome

Indonesian Biomedical Journal, 2023
BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular disease in childhood. The proposed hypothesis for the pathogenesis of this disease has changed over time, from immune dysregulation theory and systemic circulating factors theory, to the ...
Eka Laksmi Hidayati, Bambang Supriyatno, Sudung Oloan Pardede, Partini Pudjiastuti Trihono, Dewi Sukmawati, Dewi Wulandari, Oke Rina Ramayani   +6 more
doaj   +1 more source

The amino acid mutations of the podocin in proteinuria: a meta-analysis [PDF]

Renal Failure, 2015
While many previous studies have reported an association between the single-nucleotide polymorphisms (SNPs) of the podocin and proteinuria occurred, a conclusive relationship has not been defined in every oligoallelic state of amino acid (AA) mutations in podocin.
Lu, Lu, Xiao-ming, Sun, Yi, Yin, Yan-feng, Huang, Ming, Wang, Heng, Wan, Lian-Bo, Wei, Wei, Xiao   +7 more
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Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking [PDF]

, 2022
Background: NPHS2 variants are the most common cause of steroid-resistant nephrotic syndrome in >1-month-old children. Missense NPHS2 variants were reported to cause mistrafficking of the encoded protein, PODOCIN, but this conclusion was based on ...
See, Michael, Ramialison, Mirana, Howden, Sara E., Little, Melissa H., Forbes, Thomas, Melissa H. Little, Sara E. Howden, Peiris, Thanushi, Lawlor, Kynan, Saleem, Moin A., Moin A. Saleem, Catherine Quinlan, Ghobrial, Irene, Aude Dorison, Das, Mithun, Kynan T. Lawlor, Mithun Das, Thanushi Peiris, Quinlan, Catherine, Mirana Ramialison, Dorison, Aude, Lawlor, Kynan T., Michael See, Howden, Sara, Thomas A. Forbes, Little, Melissa, Graham, Alison, Forbes, Thomas A., Alison Graham, Irene Ghobrial, Saleem, Moin   +30 more
core   +1 more source

Podocin and Nephrotic Syndrome [PDF]

Journal of the American Society of Nephrology, 2004
Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in childhood. Most of the children respond to corticosteroid therapy whereas 10% of them fail to respond to this treatment.
openaire   +1 more source

Podocin mutations in sporadic focal-segmental glomerulosclerosis occurring in adulthood [PDF]

Kidney International, 2003
To the Editor: Podocin is a key component of the podocyte slit diaphragm. Mutations of podocin cause recessive steroid-resistant nephrotic syndrome that evolves to renal failure in early childhood [1]. They have also been found in children with sporadic nephrotic syndrome [2] and variable outcome including patients with steroid and cyclosporine ...
Caridi G, Bertelli R, SCOLARI, Francesco, Sanna Cherchi S, Di Duca M, Ghiggeri G.M.   +5 more
openaire   +4 more sources

Evaluation of Tryptic Podocin Peptide in Urine Sediment Using LC-MS-MRM Method as a Potential Biomarker of Glomerular Injury in Dogs with Clinical Signs of Renal and Cardiac Disorders

Molecules, 2019
The early asymptomatic stage of glomerular injury is a diagnostic challenge in the course of renal and extra-renal disease, e.g., heart insufficiency. It was found that podocin, a podocyte-specific protein present in the urine, may serve as a biomarker ...
Barbara Szczepankiewicz, Remigiusz Bąchor, Robert Pasławski, Natalia Siwińska, Urszula Pasławska, Andrzej Konieczny, Zbigniew Szewczuk   +6 more
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Enrichment of Cysteine-Containing Peptide by On-Resin Capturing and Fixed Charge Tag Derivatization for Sensitive ESI-MS Detection

Molecules, 2020
High complexity of cell and tissue proteomes limits the investigation of proteomic biomarkers. Therefore, the methods of enrichment of some chemical groups of peptides including thiopeptides are important tools that may facilitate the proteomic analysis ...
Remigiusz Bąchor, Oliwia Gorzeń, Anna Rola, Karolina Mojsa, Karolina Panek-Laszczyńska, Andrzej Konieczny, Krystyna Dąbrowska, Wojciech Witkiewicz, Zbigniew Szewczuk   +8 more
doaj   +1 more source