Results 21 to 30 of about 5,352 (196)

Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte [PDF]

Scientific Reports, 2017
AbstractThe irreversibility of glomerulosclerotic changes depends on the degree of podocyte injury. We have previously demonstrated the endocytic translocation of podocin to the subcellular area in severely injured podocytes and found that this process is the primary disease trigger.
Yu Sasaki, Teruo Hidaka, Takashi Ueno, Miyuki Akiba-Takagi, Juan Alejandro Oliva Trejo, Takuto Seki, Yoshiko Nagai-Hosoe, Eriko Tanaka, Satoshi Horikoshi, Yasuhiko Tomino, Yusuke Suzuki, Katsuhiko Asanuma   +11 more
openaire   +3 more sources

Reflective versus predictive value of urinary podocin, nephrin, and their ratio in diabetic kidney disease: a 12-month retrospective cohort study [PDF]

Frontiers in Nephrology
IntroductionPodocyte injury plays a central role in the development of diabetic kidney disease (DKD). Urinary podocin, nephrin, and the podocin–nephrin ratio (PNR) have been proposed as early indicators of glomerular injury, but their prognostic value ...
Pringgodigdo Nugroho, Jeremia Siregar, Jeremia Siregar, Tri Juli Edi Tarigan, Kuntjoro Harimurti, Aida Lydia, Evy Yunihastuti, Pradana Soewondo, Hamzah Shatri   +8 more
doaj   +2 more sources

Dynamics and Predictive Values of Urinary Podocyte Biomarkers Following SGLT2 Inhibition in CKD [PDF]

Life
Podocyte injury is an early hallmark of chronic kidney disease (CKD) and can be influenced by SGLT2 inhibitors (SGLT2i). Early effects of SGLT2i include transient estimated glomerular filtration rate (eGFR) dip and reduced proteinuria; however, the ...
Alexandra Urs, Diana Moldovan, Crina Claudia Rusu, Cosmina Ioana Bondor, Alina Ramona Potra, Dacian Tirinescu, Maria Țicală, Yuriy Maslyennikov, Andrada Alina Bărar, Ioana Dînșoreanu, Ina Maria Kacso   +10 more
doaj   +2 more sources

Pathogenic podocin variants exhibit distinct defects in trafficking, membrane organization, and degradation pathways

European Journal of Cell Biology
Nephrotic syndrome is frequently associated with pathogenic variants in NPHS2 (podocin), including the common and severe R138Q substitution. Using conditionally immortalized human podocytes expressing Myc-tagged podocin variants (G92C, V180M, R138Q ...
Pei-Chen Lu, Ruth Rollason, Chia-An Chou, Valeryia Kuzmuk, Kate J. Heesom, Moin A. Saleem, Gavin I. Welsh   +6 more
doaj   +2 more sources

NPHS2 Revisited Through 208 Cases and Podocin Complex Modeling [PDF]

Kidney International Reports
Introduction: Steroid-resistant nephrotic syndrome (SRNS) is the leading cause of chronic glomerular disease in individuals under 25 years of age. Biallelic variants in NPHS2, encoding podocin, are the most common monogenic etiology.
Nils David Mertens, Camille Nicolas Frank, Leah Bolsius, Shirlee Shril, Amar J. Majmundar, Tobias B. Huber, Friedhelm Hildebrandt, Florian Buerger   +7 more
doaj   +2 more sources

The MEC-2E isoform with a large C-terminal completely rescues the touch sensation defect of C. elegans [PDF]

Scientific Reports
Human podocin and C. elegans MEC-2 belong to the stomatin protein superfamily. They share 49% identity and 91% similarity both in the evolutionary conserved PHB domain (123-284 aa) and in the oligomerization region (273-351 aa).
Tália Magdolna Keszthelyi, Regina Légrádi, Dóra Pálya, Tímea Köles, Ágnes Regős, Dóra Karancsiné Menyhárd, Kálmán Tory   +6 more
doaj   +2 more sources

Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process [PDF]

Frontiers in Cell and Developmental Biology, 2023
Introduction: The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed slit ...
Gary F. Gerlach, Zachary H. Imseis, Shamus L. Cooper, Anabella N. Santos, Lori L. O’Brien   +4 more
doaj   +2 more sources

Co-Localization of Nephrin, Podocin, and the Actin Cytoskeleton [PDF]

The American Journal of Pathology, 2002
The discovery of the genes for nephrin and podocin, which are mutated in two types of congenital nephrotic syndrome, was pivotal in establishing the podocyte as the central component of the glomerular filtration barrier.
Moin A. Saleem, Lan Ni, Ian Witherden, Karl Tryggvason, Vesa Ruotsalainen, Peter Mundel, Peter W. Mathieson   +6 more
openaire   +2 more sources

Longitudinal Study of the Vascular Glycocalyx and Urinary Podocyte Markers During Pregnancy [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to assess the longitudinal changes of glycocalyx, a proteoglycan/glycoprotein layer that lines and protects endothelial cells in normotensive pregnancies (NPs); to correlate glycocalyx parameters with kidney injury markers (podocin ...
Oscar Garcia Valencia, Sonja Suvakov, Haitao Tu, Darah Dilmaghani, Natasa M. Milic, Tracey L. Weissgerber, Vladimir Dokic, Paul Gavrilovici, Jennet Hatamova, Jing Miao, Wendy M. White, Muthuvel Jayachandran, Karl Nath, Vesna D. Garovic   +13 more
doaj   +2 more sources

Early detection of active glomerular lesions in dogs and cats using podocin [PDF]

Journal of Veterinary Research, 2019
In veterinary medicine, sensitive and specific markers of the early stages of renal failure still remain to be established. Podocytes could be a promising diagnostic tool in veterinary nephrology, especially in the differentiation of active pathological ...
Szczepankiewicz Barbara, Pasławska Urszula, Nowak Marcin, Bąchor Remigiusz, Czyżewska-Buczyńska Agnieszka, Pasławski Robert, Szewczuk Zbigniew   +6 more
doaj   +3 more sources