In vivo characterization of a podocyte-expressed short podocin isoform [PDF]
BMC Nephrology, 2023 The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a
Linus Butt +8 more
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Structural features and oligomeric nature of human podocin domain
Biochemistry and Biophysics Reports, 2020 Podocytes are crucial cells of the glomerular filtration unit and plays a vital role at the interface of the blood-urine barrier. Podocyte slit-diaphragm is a modified tight junction that facilitates size and charge-dependent permselectivity.
Sandeep K N Mulukala +2 more
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Evaluation of podocin in urine in horses using qualitative and quantitative methods.
PLoS ONE, 2020 No sensitive method for diagnosing early kidney dysfunction in horses has been identified so far. Many studies carried out in humans and small animals show that podocin can be useful to diagnose various kidney diseases, mainly affecting the glomeruli ...
Natalia Siwińska +6 more
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An inducible mouse model of podocin-mutation-related nephrotic syndrome. [PDF]
PLoS ONE, 2017 Mutations in the NPHS2 gene, encoding podocin, cause hereditary nephrotic syndrome. The most common podocin mutation, R138Q, is associated with early disease onset and rapid progression to end-stage renal disease. Knock-in mice carrying a R140Q mutation,
Mansoureh Tabatabaeifar +11 more
doaj +6 more sources
In silico Structural characterization of podocin and assessment of nephrotic syndrome‐associated podocin mutants [PDF]
IUBMB Life, 2016 AbstractNephrotic syndrome (NS) is manifested by hyperproteinuria, hypoalbuminemia, and edema. NPHS2 that encodes podocin was found to have most mutations among the genes that are involved in the pathophysiology of NS. Podocin, an integral membrane protein belonging to stomatin family, is expressed exclusively in podocytes and is localized to slit ...
Mulukala, Sandeep Kumar Narasimha +5 more
openaire +6 more sources
Clinical Determinants of Urinary Podocyte Biomarkers and Their Feasibility in Paraprotein-Related Kidney Disease [PDF]
DiagnosticsBackground/Objectives: Kidney injury is a frequent complication of multiple myeloma (MM) and monoclonal gammopathies. Podocyte stress markers, such as urinary nephrin and podocin, have been studied in other renal diseases but their utility in paraprotein-
Oliver Helk +6 more
doaj +2 more sources
Urinary podocin level as a predictor of diabetic kidney disease [PDF]
Journal of Nephropathology, 2019 Background: Albuminuria showed to be a deteriorating condition in diabetic kidney disease (DKD) associated with high morbidity and mortality. A need for a novel marker for early detection of DKD development and progression becomes mandating.
Abdelbassit ElShaarawy +4 more
doaj +2 more sources
A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems. [PDF]
PLoS ONE, 2013 Mutations in the gene NPHS2 are the most common cause of hereditary steroid-resistant nephrotic syndrome. Its gene product, the stomatin family member protein podocin represents a core component of the slit diaphragm, a unique structure that bridges the ...
Markus Gödel +4 more
doaj +2 more sources
Evaluation of urinary podocin and nephrin as markers of podocyturia in dogs with leishmaniosis [PDF]
Parasites & VectorsBackground Renal disease is the main cause of death in canine leishmaniosis. Detection of an active glomerular injury is important to identify early renal damage and to prevent the development of chronic kidney disease.
Valeria Pantaleo +4 more
doaj +5 more sources
Autoantibodies against nephrin and podocin are associated with disease severity and steroid dependence in adult-onset nephrotic syndrome [PDF]
Scientific ReportsNephrotic syndrome is a glomerular disorder characterized by heavy proteinuria and hypoalbuminemia. Autoantibodies against slit diaphragm proteins such as nephrin and podocin have been identified in subsets of patients, but their prevalence and clinical ...
Norifumi Hayashi +6 more
doaj +2 more sources