Results 31 to 40 of about 5,352 (196)

Urinary exosomes aggravate diabetic kidney disease by inducing podocyte ferroptosis via the miR-217/SIRT1/Nrf2 pathway. [PDF]

J Cell Commun Signal
These findings indicate that urinary exosomal miR‐217 promotes podocyte ferroptosis and DKD progression via suppression of the SIRT1/Nrf2 pathway, suggesting a potential therapeutic target for DKD. Abstract Urinary exosomal microRNAs (miRNAs) mediate intercellular communication in diabetic kidney disease (DKD), a leading contributor to end‐stage renal ...
Du X, Jiang Y, Guo H, Zhang H, Wang S, Deng H, Huang X, Li X.   +7 more
europepmc   +2 more sources

Experimental Validation and Bioinformatics Analysis Elucidate the Role of MTDH-Mediated PTEN Ubiquitination and Degradation in Podocyte Injury in Diabetic Kidney Disease. [PDF]

Hum Mutat
Diabetic nephropathy (DN) stands as a primary contributor to end‐stage renal disease. Podocyte injury is a key factor underlying proteinuria in DN. Metadherin (MTDH) participates in podocyte apoptosis and promotes renal tubular injury in DN. However, its role in podocyte damage and podocyte cytoskeleton remodeling requires further investigation.
Zheng Z, Tao D, Wu W, Zhang H, Shen L, He X, Zheng X, Long Y, Yang J, Chen X, Peng F, Long H, Luo C.   +12 more
europepmc   +2 more sources

Podocyte specific knockout (KO) of the natriuretic peptide clearance receptor (NPRC) attenuates diabetic kidney disease (DKD). [PDF]

Physiol Rep
Abstract Glomerular podocytes play a key role in the pathogenesis of diabetic kidney disease (DKD). Recent studies suggest that natriuretic peptides (NPs) are podocyte protective. The beneficial effects of NPs are inhibited by the removal of NPs from the circulation by the NP clearance receptor (NPRC).
Wang L, Tang Y, Dai Q, Buckley AF, Spurney RF.   +4 more
europepmc   +2 more sources

A Rare NPHS2 Mutation (E130K) in Hereditary Steroid-Resistant Nephrotic Syndrome: A Case Report. [PDF]

Case Rep Nephrol
Hereditary steroid‐resistant nephrotic syndrome (HSRNS) due to mutations in the NPHS2 gene (encoding podocin) is a rare genetic condition that typically presents in childhood. We report a case of a 2‐year‐and‐8‐month‐old male, the seventh child of consanguineous parents, who presented with recurrent fever, febrile tonic‐clonic seizures, and periorbital
Mujahed RH, Salloum OH, Ishreiteh NF, Hosheyh HM, Hashem ADA, Shamestti YF, Hroub MR.   +6 more
europepmc   +2 more sources

Peptide Charge Derivatization as a Tool for Early Detection of Preeclampsia by Mass Spectrometry—A Comparison with the ELISA Test

Molecules, 2021
Early detection of any preeclampsia biomarkers may lower the risk of mortality, both for a mother and a child. Our study focuses on techniques for preeclampsia biomarker identification by comparing the results of a method using liquid chromatography mass
Paulina Grocholska, Andrzej Konieczny, Zuzanna Kaźmierczak, Krystyna Dąbrowska, Karolina Panek-Laszczyńska, Marlena Kłak, Wojciech Witkiewicz, Zbigniew Szewczuk, Remigiusz Bąchor   +8 more
doaj   +1 more source

Interaction with Podocin Facilitates Nephrin Signaling [PDF]

Journal of Biological Chemistry, 2001
Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. In addition, mice lacking CD2-associated protein (CD2AP) develop a nephrotic syndrome that resembles NPHS mutations suggesting that all three proteins are essential for the integrity of glomerular podocytes ...
Huber, Tobias B., Köttgen, Michael, Schilling, Birgit, Walz, Gerd, Benzing, Thomas   +4 more
openaire   +3 more sources

miR-135a-5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure. [PDF]

Adv Sci (Weinh)
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Zhao X, Chen H, Zhu Y, Xia Z, He H, Liu Y, Yang T, Wang H, Ao Y.   +8 more
europepmc   +2 more sources

Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury [PDF]

Journal of Biological Chemistry, 2020
Podocyte injury is a critical step toward the progression of renal disease and is often associated with a loss of slit diaphragm proteins, including Podocin. Although there is a possibility that the extracellular domain of these slit diaphragm proteins can be a target for a pathological proteolysis, the precise mechanism driving the phenomenon remains ...
Shota Ozawa, Masaya Matsubayashi, Hitoki Nanaura, Motoko Yanagita, Kiyoshi Mori, Katsuhiko Asanuma, Nobuyuki Kajiwara, Kazuyuki Hayashi, Hiroshi Ohashi, Masato Kasahara, Hideki Yokoi, Hiroaki Kataoka, Eiichiro Mori, Takahiko Nakagawa   +13 more
openaire   +2 more sources

Podocin Localizes in the Kidney to the Slit Diaphragm Area [PDF]

The American Journal of Pathology, 2002
We recently cloned a novel gene, NPHS2, involved in autosomal recessive steroid-resistant nephrotic syndrome. This gene encodes a novel podocyte protein, podocin. Given its similarity with the stomatin family proteins, podocin is predicted to be an integral membrane protein with a single membrane domain forming a hairpin-like structure placing both N ...
Séverine, Roselli, Olivier, Gribouval, Nicolas, Boute, Mireille, Sich, France, Benessy, Tania, Attié, Marie-Claire, Gubler, Corinne, Antignac   +7 more
openaire   +2 more sources

Broadening the Spectrum of Diseases Related to Podocin Mutations [PDF]

Journal of the American Society of Nephrology, 2003
A total of 179 children with sporadic nephrotic syndrome were screened for podocin mutations: 120 with steroid resistance, and 59 with steroid dependence/frequent relapses. Fourteen steroid-resistant patients presented homozygous mutations that were associated with early onset of proteinuria and variable renal lesions, including one case with mesangial
CARIDI G, BERTELLI R, DI DUCA M, DAGNINO M, EMMA F, ONETTI MUDA A, SCOLARI, Francesco, MIGLIETTI N, MAZZUCCO G, MURER L, CARREA A, MASSELLA L, RIZZONI G, PERFUMO F, GHIGGERI G.M.   +14 more
openaire   +3 more sources