Results 91 to 100 of about 5,352 (196)

A Novel CRB2 Mutation Associated With FSGS and ESRD in an Adult Patient

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Background Chronic kidney disease (CKD) is a major global health concern, with a substantial proportion of cases that remain of undetermined cause. Mutations in genes affecting podocyte structure and function, are increasingly recognized as causes of focal segmental glomerulosclerosis (FSGS), a common but highly nonspecific histological pattern of ...
Michele Marchini, Sonila Mocka, Matteo Trezzi, Poorani Gurumallesh   +3 more
wiley   +1 more source

A Review of Focal Segmental Glomerulosclerosis Classification With a Focus on Genetic Associations

Kidney Medicine
Focal segmental glomerulosclerosis (FSGS) defines a distinct histologic pattern observed in kidney tissue that is linked to several distinct underlying causes, all converging on the common factor of podocyte injury.
Marco Bonilla, Orhan Efe, Haresh Selvaskandan, Edgar V. Lerma, Nasim Wiegley   +4 more
doaj   +1 more source

Urine‐Derived Stem Cells: Applications of Paracrine‐Driven Regeneration and Functional Recovery in Multiorgan Systems

Stem Cells International, Volume 2026, Issue 1, 2026.
Stem cell therapy, a highly recognized approach in the field of regenerative medicine, is known for its potential to stimulate the self‐healing process of the body using stem cells or their derivatives, in which urine‐derived stem cells (USCs) stand out as a novel and promising tool in treating various diseases recently.
Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Dongkai Sun, Ye Liang, Harleen Khatra   +6 more
wiley   +1 more source

Specific Podocin Mutations Correlate With Age Of Onset In Steroid-Resistant Nephrotic Syndrome

, 2008
Mutations in the gene encoding podocin (NPHS2) cause autosomal recessive steroid-resistant nephrotic syndrome (SRNS). For addressing the possibility of a genotype-phenotype correlation between podocin mutations and age of onset, a worldwide cohort of 430
Bernward Hinkes, Fatih Ozaltin, Christopher Vlangos, Katrin Hasselbacher, Hildebrandt, Friedhelm, Rasheed Gbadegesin, Jinhong Liu, Bettina Mucha, Heeringa, Saskia, Mucha, Bettina, Friedhelm Hildebrandt, Gbadegesin, Rasheed, Saskia Heeringa, Hasselbacher, Katrin, Vlangos, Christopher, Hinkes, Bernward, Ozaltin, Fatih, Liu, Jinhong   +17 more
core   +1 more source

Induction of Nephron–Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim, Seeun Kim, Dong Hyun Lee, Dae Hun Kim, Hye Bin Lee, Ye Seul Son, Mi‐Young Son, Soo Jin Oh, Ji‐Yoon Lee, Mi‐Ok Lee, Hyun Soo Cho, Dae‐Soo Kim, Cho‐Rok Jung, Hyun Mi Kang   +13 more
wiley   +1 more source

Effect of Sirt1 on high glucose-induced exosome release from podocytes [PDF]

精准医学杂志
Objective To investigate the effect of nicotinamide adenine dinucleotide-dependent deacetylase 1 (Sirt1) on high glucose-induced exosome release from podocytes. Methods Immortalized mouse podocytes MPC5 were divided into six groups: normal glucose group (
DING Lin, ZHOU Yan, LIU Shanshan, LIU Nanchi, MA Ruixia
doaj   +1 more source

Podocin localizes to endosomal vesicles. Immunofluorescence for transiently expressed, V5- (a–c, e) or Flag-tagged (d) podocin using anti-V5 or anti-Flag antibody in HeLa cells.

, 2013
Costainings of endogenous calnexin (a), endogenous golgin-97 (b), endogenous EEA1 (c), Lysotracker Red (d) and eGfp-tagged and transiently expressed CD63 (e) as markers for the endoplasmatic reticulum, Golgi apparatus, early endosomes, acidic organelles ...
Markus Gödel (152664), Tobias B. Huber (152684), Katrin Weber (378647), Benjamin N. Ostendorf (378645), Jessica Baumer (378646)   +4 more
core   +1 more source

Podocin reguliert TRPC6 Ionenkanäle an der Schlitzmembran

, 2011
Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal disease. A variety of recent evidence supports the notion of the glomerular podocyte and the slit diaphragm as central components of the renal filtration barrier ...
Koos, Fabienne
core  

Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome

, 2009
Podocin is a critical component of the glomerular slit diaphragm, and genetic mutations lead to both familial and sporadic forms of steroid-resistant nephrotic syndrome.
D. Kitzis, Boyer, O., Muda, A.O., Dallman, M.J., Antignac, C., G. Mollet, M. J. Dallman, Lavin, T.A., Esquive, E.L., Huebner, N., T. A. Lavin, Ratelade, J., Gubler, M.C., Morisset, L., J. Ratelade, Mollet, G., C. Antignac, Kitzis, D., L. Bugeon, E. L. Esquivel, M.-C. Gubler, O. Boyer, N. Hubner, Bugeon, L., A. O. Muda, L. Morisset   +25 more
core   +1 more source

Thymol alleviates AGEs-induced podocyte injury by a pleiotropic effect via NF-κB-mediated by RhoA/ROCK signalling pathway

Cell Adhesion & Migration, 2020
Advanced glycation end products (AGE) are those of the most powerful pathogenic factors that related to diabetic complications. In our study, we investigated the beneficial effects of thymol on AGE induced cell injury and apoptosis in human podocytes ...
Qinglian Wang, Zhenwei Shen, Guanghui Qi, Yanfang Zhao, Hongge Zhang, Rong Wang   +5 more
doaj   +1 more source