Results 181 to 190 of about 7,139 (201)

Glomage : A multimodal platform for high-content morphological and RNA profiling of glomeruli in zebrafish and mouse models

Schindler M, Lange T, Bach S, Lienkamp SS, Endlich N.   +4 more
europepmc   +1 more source

日本人症例におけるNPHS1変異の機能解析 [PDF]

, 2014
Miyai, Takayuki
core  

Dampness syndrome aggravates T helper 17/regulatory T imbalance to promote renal injury in rats with experimental membranous nephropathy. [PDF]

J Tradit Chin Med
Wenjun S, Haowen GU, Haiyu G, Ping LI, Yi W, Miaoru H, Houchun W, Xiaoyan H, Kun B.   +8 more
europepmc   +1 more source

The prevalence of podocin (NPHS2) mutations in patients with FSGS

NDT Plus, 2008
Kazimierczak, Krzysztof, Penar, Józef, Drulis-Fajdasz, Dominika, Klinger, Marian   +3 more
openaire  

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Imaging of Podocytic Proteins Nephrin, Actin, and Podocin with Expansion Microscopy

Journal of Visualized Experiments, 2021
Disruption of the glomerular filter composed of the glomerular endothelium, glomerular basement membrane and podocytes, results in albuminuria. Podocyte foot processes contain actin bundles that bind to cytoskeletal adaptor proteins such as podocin. Those adaptor proteins, such as podocin, link the backbone of the glomerular slit diaphragm, such as ...
Eva, Königshausen, Christina Theresa, Schmitz, Lars Christian, Rump, Lorenz, Sellin   +3 more
openaire   +2 more sources

NEPH1 defines a novel family of podocin‐interacting proteins

The FASEB Journal, 2002
ABSTRACT Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid‐resistant proteinuria. In addition, mice lacking NEPH1 develop a nephrotic syndrome that resembles NPHS mutations, suggesting that all three proteins are essential for the integrity of ...
Sellin, Lorenz, Huber, Tobias B., Gerke, Peter, Quack, Ivo, Pavenstädt, Hermann, Walz, Gerd   +5 more
openaire   +3 more sources

Mutated podocin manifesting as CMV-associated congenital nephrotic syndrome

Pediatric Nephrology, 2003
We report a girl with congenital nephrotic syndrome (CNS) associated with cytomegalovirus (CMV) infection and histological findings on renal biopsy that suggested a causal relationship between the two. She was subsequently found to be homozygous for a nonsense mutation in the NPHS2 gene encoding podocin (R138X), which is the true cause of her NS. Based
Yaacov, Frishberg, Choni, Rinat, Sofia, Feinstein, Rachel, Becker-Cohen, Orli, Megged, Yechiel, Schlesinger   +5 more
openaire   +2 more sources

ANGPTL4 promotes nephrotic syndrome by downregulating podocyte expression of ACTN4 and podocin

Biochemical and Biophysical Research Communications, 2023
lipopolysaccharide (LPS) can induce nephrotic syndrome-like features such as massive proteinuria, hyperlipidemia, and fusion of glomerular podocytes with foot processes (FPs) in mice. Angiopoietin-like protein 4 (ANGPTL4) neutralized the negative charge of glomerular basement membrane charge and aggravated renal injury.
Yue, Li, Zichuan, Xu, Hui, Deng, Ming, Liu, Xiaoqing, Lin, Miao, Zhang, Guanyu, Li, Shuling, Yue, Xia, Gao   +8 more
openaire   +2 more sources

Intracellular mislocalization of mutant podocin and correction by chemical chaperones

Histochemistry and Cell Biology, 2003
The NPHS2 gene encoding the podocin protein was causally linked to the autosomal recessive type of steroid-resistant nephrotic syndrome. In this study, we investigated the consequence of the R138Q mutation of podocin, one of the most common missense mutations in the NPHS2 gene, by examining the expression of the wild-type and R138Q mutant podocins in ...
Teiko, Ohashi, Keiko, Uchida, Shinichi, Uchida, Sei, Sasaki, Hiroshi, Nihei   +4 more
openaire   +2 more sources

Electronic microarray screening of podocin mutations: a single-center study

International Urology and Nephrology, 2008
Because of resistance to immunosuppressants in nephrotic syndrome and reduction of proteinuria relapses following renal transplantation, it seems that new horizons have arisen from mutational screening of the podocin gene. The aim of this study was to assess electronic microarray screening of the podocin mutation.Twelve previously identified podocin ...
Onur, Sakallioglu, Faysal, Gok, Suleyman, Kalman, Davut, Gul, Hande, Barutcu, Nurcan, Cengiz, Esra, Baskin   +6 more
openaire   +2 more sources