Results 91 to 100 of about 28,951 (302)
Advanced Science, EarlyView.Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma +11 more
wiley +1 more source
The Beneficial Role of Retinoids in Glomerular Disease
Frontiers in Medicine, 2015 The primary etiology of CKD is a direct consequence of initial dysfunction and injury of the glomerulus, the main filtration system. Podocytes are terminally differentiated epithelial cells in the glomerulus, whose major function is the maintenance of ...
Sandeep eMallipattu, John Cijiang He
doaj +1 more source
Pathogenesis of Focal Segmental Glomerulosclerosis [PDF]
Journal of Pathology and Translational Medicine, 2016 Focal segmental glomerulosclerosis (FSGS) is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix. FSGS is classified as collapsing, tip, cellular, perihilar and not otherwise specified variants according ...
Beom Jin Lim +3 more
doaj +1 more source
C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation [PDF]
, 2019 Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to podocyte hypertrophy, but the detailed mechanism of how mTORC1 activation occurs under pathological conditions is not completely ...
Ha, Tae-Sun +6 more
core +1 more source
Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA
Advanced Science, EarlyView.This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li +14 more
wiley +1 more source
Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy
JCI Insight, 2023 Albuminuria and podocyte injury are the key cellular events in the progression of diabetic nephropathy (DN). Acetyl-CoA synthetase 2 (ACSS2) is a nucleocytosolic enzyme responsible for the regulation of metabolic homeostasis in mammalian cells.
Jian Lu +11 more
doaj +1 more source
Non-canonical NFκB activation promotes chemokine expression in podocytes [PDF]
, 2016 TNF-like weak inducer of apoptosis (TWEAK) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease. However, the downstream effectors of TWEAK/Fn14 in podocytes are poorly characterized.
Gonzalez-Lafuente, Laura +5 more
core +2 more sources
Advanced Science, EarlyView.LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu +11 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes associated with podocyte injury in chronic kidney disease (CKD) by weighted gene correlation ...
Zhi Zuo +6 more
doaj +1 more source
A rare case of renal thrombotic microangiopathy associated with Castleman’s disease [PDF]
, 2017 BACKGROUND: Castleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF).
Chen, Ying Maggie +3 more
core +2 more sources