Results 91 to 100 of about 30,263 (304)

Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy.

PLoS ONE, 2021
The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood.
Jeong Suk Kang, Seung Seob Son, Ji-Hye Lee, Seong Woo Lee, Ah Reum Jeong, Eun Soo Lee, Seung-Kuy Cha, Choon Hee Chung, Eun Young Lee   +8 more
doaj   +1 more source

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review [PDF]

, 2020
Background A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer’s disease and vascular dementia ...
Bell, J.D., Bell, J.D., Bligh, S.W.A., Bligh, S.W.A., Katsuno, T., Katsuno, T., Parkinson, J., Parkinson, J., Shinjyo, N., Shinjyo, N.   +9 more
core   +1 more source

Podocyte Injury Can Be Catching [PDF]

Journal of the American Society of Nephrology, 2011
Podocyte loss is a central mediator of glomerular sclerosis. Because podocytes are terminally differentiated cells that lack the potential to proliferate, they are particularly vulnerable to attrition in response to critical levels of cell stress, leading to detachment, necrosis, or apoptosis ...
openaire   +1 more source

The MIF Receptor CD74 in Diabetic Podocyte Injury [PDF]

Journal of the American Society of Nephrology, 2009
Although metabolic derangement plays a central role in diabetic nephropathy, a better understanding of secondary mediators of injury may lead to new therapeutic strategies. Expression of macrophage migration inhibitory factor (MIF) is increased in experimental diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor, CD74,
Sanchez-Nino, MD, Sanz, AB, Ihalmo, P, Lassila, M, Holthofer, H, Mezzano, S, Aros, C, Groop, PH, Saleem, MA, Mathieson, PW, Langham, R, Kretzler, M, Nair, V, Lemley, KV, Nelson, RG, Mervaala, E, Mattinzoli, D, Rastaldi, MP, Ruiz-Ortega, M, Martin-Ventura, JL, Egido, J, Ortiz, A   +21 more
openaire   +6 more sources

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, EarlyView.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy

JCI Insight, 2023
Albuminuria and podocyte injury are the key cellular events in the progression of diabetic nephropathy (DN). Acetyl-CoA synthetase 2 (ACSS2) is a nucleocytosolic enzyme responsible for the regulation of metabolic homeostasis in mammalian cells.
Jian Lu, Xue Qi Li, Pei Pei Chen, Jia Xiu Zhang, Liang Liu, Gui Hua Wang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Zhong Ruan, Kun Ling Ma   +11 more
doaj   +1 more source

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2:Implications for podocyte depletion and proteinuria in diabetes mellitus [PDF]

, 2015
Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). N-carboxymethyl-lysine (CML) is one of the predominant AGEs that accumulate in all renal compartments of diabetic patients.
Kumar, P Anil, Menon, Ram K, Raghu, G, Reddy, G Bhanuprakash, Saleem, Moin A, Welsh, Gavin I   +5 more
core   +2 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Cell Death and Disease, 2022
Podocyte injury and loss are critical events in diabetic nephropathy (DN); however, the underlying molecular mechanisms remain unclear. Here, we demonstrate that asparaginyl endopeptidase (AEP) protects against podocyte injury through modulating the ...
Chuntao Lei, Mengran Li, Yang Qiu, Yaru Xie, Zhe Hao, Xingjie Yin, Zhentao Zhang, Hua Su, Linlin Yang, Jihong Lin, Hans-Peter Hammes, Chun Zhang   +11 more
doaj   +1 more source

Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms [PDF]

, 2016
Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the ...
Coward, RJ, Gnudi, L, Long, DA
core   +1 more source