Results 121 to 130 of about 28,951 (302)

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]

, 2016
Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji, Imamaki, Hirotaka, Ishii, Akira, Kasahara, Masato, Kuwabara, Takashige, Kuwahara, Koichiro, Mori, Kiyoshi, Mori, Yasuo, Mukoyama, Masashi, Naito, Masaki, Nakao, Kazuwa, Numata, Tomohiro, Ohno, Shoko, Saleem, Moin, Yanagita, Motoko, Yokoi, Hideki   +15 more
core   +3 more sources

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Extracellular vesicles derived from silicate‐stimulated antler reserve mesenchymal cells alleviate kidney damage in diabetic nephropathy through inhibiting abnormal angiogenesis and apoptosis

VIEW, EarlyView.
A novel bioengineering platform was invented to harness simple silicate ions to command highly regenerative deer antler cells, transforming them into super‐factories that massively produce customized extracellular vesicles (Si‐RM‐EVs) rich in therapeutic miR‐148a‐3p, dwarfing natural EV output and payload.
Pengfei Hu, Zhaowenbin Zhang, Dongxu Wang, Xiuying Li, Jiping Li, Jinchi Ying, Tiantian Jiang, Chen Zhao, Jiang Chang, Chunyi Li   +9 more
wiley   +1 more source

The effects of dual PPARα/γ agonism compared with ACE inhibition in the BTBRob/ob mouse model of diabetes and diabetic nephropathy [PDF]

, 2017
The leptin-deficient BTBRob/ob mouse develops progressive albuminuria and morphological lesions similar to human diabetic nephropathy (DN), although whether glomerular hyperfiltration, a recognized feature of early DN that may contribute to renal injury,
Böttcher, G, Ericsson, A, Hyberg, G, Johansson, C, Jönsson-Rylander, A-C, Lal, M, Sabirsh, A, Strömstedt, M, Tapani, S, Tonelius, P, Unwin, R, William-Olsson, L   +11 more
core   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Current Progress of Tissue Engineering With Stem Cells in Urology Updated Review in 2025

International Journal of Urology, EarlyView.
ABSTRACT Tissue engineering, a key component of regenerative medicine, aims to restore the structure and function of damaged organs using combinations of cells, scaffolds, and bioactive factors. In urology, the integration of stem cell biology has fueled significant progress in preclinical models for kidney, bladder, and urethral regeneration ...
Kenichi Kobayashi, Tsunehito Horii, Akinori Wada, Kazuaki Yamanaka, Akeo Hagiwara, Susumu Kageyama   +5 more
wiley   +1 more source

Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]

, 2018
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Asfahani, R, Bellerby, J, Hohenstein, P, Miller-Hodges, EV, Moulding, D, Sampson, RD, Scambler, PJ, Sebire, NJ, Tahoun, MM, Virasami, AK, Waters, AM   +10 more
core  

Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]

, 2018
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J., Petrie, John R., Touyz, Rhian M.   +2 more
core   +1 more source

Development of a Novel Diagnostic Test Using Podocyturia as a Biomarker for Detection of Kidney Damage [PDF]

, 2013
Primary glomerular diseases are the most common cause of progressive chronic kidney disease (CKD) in dogs, a common and significant source of illness that often progresses to kidney failure.
Farooqi, Eesha
core   +1 more source

Pazopanib-induced Endothelial Injury with Podocyte Changes

Internal Medicine, 2018
Pazopanib has been reported to induce proteinuria; however, no pathological findings have been reported. We herein report the case of a 31-year-old man with rhabdomyosarcoma treated with pazopanib who developed nephrotic syndrome. A renal biopsy revealed endothelial injury with podocyte changes.
Naoki Nakagawa, Motoki Matsuki, Maki Kabara, Motohiro Shindo, Yayoi Ogawa, Keisuke Maruyama, Ayana Suzuki, Naoyuki Hasebe   +7 more
openaire   +3 more sources