Results 161 to 170 of about 30,263 (304)

C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice [PDF]

, 2019
Liwen Zhang, Fangfang Zhou, Xialian Yu, Yufei Zhu, Minghao Yin, Jian Liu, Yunzi Liu, Qingyang Ma, Yuchao Zhang, Weiming Wang, Nan Chen   +10 more
openalex   +1 more source

An Atypical Presentation of Tubulointerstitial Nephritis With Uveitis (TINU) in an Older Patient Requiring Emergency Dialysis: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Tubulointerstitial nephritis with uveitis (TINU) is an immune‐mediated systemic disorder most commonly described in adolescents and young adults, and its recognition in older patients remains challenging. We report the case of a 58‐year‐old woman who presented with systemic symptoms and rapidly progressive acute kidney injury.
Yuli Yang, Yangna Shi, Jian Li, Jing Meng, Wenyu Gong   +4 more
wiley   +1 more source

New Ways of Thinking about Proteinuria and Progression of Renal Damage [PDF]

, 2010
Turner, Neil, Zhou, Y. S.
core   +1 more source

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng   +6 more
wiley   +1 more source

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

DUSP1 Attenuates Renal Injury in Diabetic Nephropathy by Modulating Ferroptosis: Evidence From Animal Experiments

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Objective Emerging evidence suggests that ferroptosis contributes significantly to the progression of diabetic nephropathy (DN). This study aimed to explore the potential association between dual specificity phosphatase 1 (DUSP1) and ferroptosis in a streptozotocin‐induced DN rat model.
Jiarong Liu, Junping Zhang, Yun Zou, Wen Chen, Jixiong Xu   +4 more
wiley   +1 more source

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

Collapsing glomerulopathy: A 30-year perspective and single, large center experience [PDF]

, 2017
Cossey, Nicholas, Larsen, Christopher P, Liapis, Helen   +2 more
core   +2 more sources

Focal Podocyte Injury [PDF]

, 2020
openaire   +1 more source

The biology of PKM2 in the metabolism and senescence in diabetic kidney disease

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 197-204, February 2026.
ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from normal oxidative phosphorylation toward glycolysis.
Md. Imrul Kayes, Keizo Kanasaki
wiley   +1 more source