Results 11 to 20 of about 30,263 (304)

MicroRNAs in Podocyte Injury in Diabetic Nephropathy [PDF]

Frontiers in Genetics, 2020
Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii, Shohei Kaneko, Katsunori Yanai, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita   +7 more
doaj   +3 more sources

Disruption of Myosin 1e Promotes Podocyte Injury [PDF]

Journal of the American Society of Nephrology, 2008
Myosin 1e (Myo1e) is one of two Src homology 3 domain-containing "long-tailed" type I myosins in vertebrates, whose functions in health and disease are incompletely understood. Here, we demonstrate that Myo1e localizes to podocytes in the kidney. We generated Myo1e-knockout mice and found that they exhibit proteinuria, signs of chronic renal injury ...
Mira Krendel, Sangwon V. Kim, Tim Willinger, Tong Wang, Michael Kashgarian, Richard A. Flavell, Mark S. Mooseker   +6 more
openalex   +4 more sources

Podocyte Injury Damages Other Podocytes [PDF]

Journal of the American Society of Nephrology, 2011
Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji, Matsusaka, Eric, Sandgren, Ayumi, Shintani, Valentina, Kon, Ira, Pastan, Agnes B, Fogo, Iekuni, Ichikawa   +6 more
openaire   +2 more sources

Podocyte Injury in Lupus Nephritis [PDF]

Journal of Clinical Medicine, 2019
Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions. In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) deposits and hypercellularity lesions (mesangial and/or endocapillary) in the glomeruli.
Sakhi, Hamza, Moktefi, Anissa, Bouachi, Khedidja, Audard, Vincent, Hénique, Carole, Remy, Philippe, Ollero, Mario, El Karoui, Khalil   +7 more
openaire   +3 more sources

Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

Frontiers in Pharmacology, 2022
Podocyte is also called glomerular epithelial cell, which has been considered as the final gatekeeper of glomerular filtration barrier (GFB). As a major contributor to proteinuria, podocyte injury underlies a variety of glomerular diseases and becomes ...
Tianwen Yao, Wenxiang Su, Shisheng Han, Yan Lu, Yanqiu Xu, Min Chen, Yi Wang   +6 more
doaj   +1 more source

Abnormal Crosstalk between Endothelial Cells and Podocytes Mediates Tyrosine Kinase Inhibitor (TKI)-Induced Nephrotoxicity

Cells, 2021
Vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2 are the main targets of antiangiogenic therapies, and proteinuria is one of the common adverse events associated with the inhibition of the VEGFA/VEGFR2 pathway.
Xiaoying Gu, Su Zhang, Ti Zhang
doaj   +1 more source

Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]

PLoS ONE, 2012
BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu, Wei Shi, Houqin Xiao, Xinling Liang, Chunyu Deng, Zhiming Ye, Ping Mei, Suxia Wang, Xiaoying Liu, Zhixin Shan, Yongzheng Liang, Bin Zhang, Wenjian Wang, Yanhui Liu, Lixia Xu, Yunfeng Xia, Jianchao Ma, Zhilian Li   +17 more
doaj   +1 more source

Traditional Chinese Medicine in Treating Primary Podocytosis: From Fundamental Science to Clinical Research

Frontiers in Pharmacology, 2022
Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as “podocyte disease.” There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations.
Lirong Lin, En Tian, Jiangwen Ren, Zhifeng Wu, Junhui Deng, Jurong Yang   +5 more
doaj   +1 more source

Podocyte injuries exacerbate mesangial proliferative glomerulonephritis [PDF]

Kidney International, 2001
From the observations of morphology seen in early phases of the experimental models of the irreversible mesangial proliferative glomerulonephritis, we hypothesized that podocyte injury is one of the important factors in bringing upon irreversible glomerular alterations.
Morioka, Yoshio, Koike, Hiroko, Ikezumi, Yohei, Ito, Yumi, Oyanagi, Akihisa, Gejyo, Fumitake, Shimizu, Fujio, Kawachi, Hiroshi   +7 more
openaire   +2 more sources

Podocyte Biology and Response to Injury [PDF]

Journal of the American Society of Nephrology, 2002
The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms the final barrier to protein loss, which explains why podocyte injury is typically associated with ...
Peter, Mundel, Stuart J, Shankland
openaire   +2 more sources