Results 61 to 70 of about 30,263 (304)

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy

Journal of Diabetes Research, 2020
Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional
Lili Zhang, Zhige Wen, Lin Han, Yujiao Zheng, Yu Wei, Xinmiao Wang, Qing Wang, Xinyi Fang, Linhua Zhao, Xiaolin Tong   +9 more
doaj   +1 more source

Innate Immune Activity in Glomerular Podocytes [PDF]

, 2017
Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types.
Hong Xia, Shaolin Shi, Wenduona Bao
core   +1 more source

Podocyte injury associated glomerulopathies induced by pamidronate [PDF]

Kidney International, 2004
Pamidronate has been demonstrated to decrease bone-related complications in multiple myeloma and delay progression of the disease. This has led to its use in supportive and maintenance therapy of myeloma in conjunction with steroids and chemotherapy. It has also been selectively used in patients with breast cancer and other neoplasms.We report on five ...
Barri, Yousri M., Munshi, Nikhil C., Sukumalchantra, Suteetat, Abulezz, Sameh R., Bonsib, Stephen M., Wallach, Jeffrey, Walker, Patrick D.   +6 more
openaire   +2 more sources

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science
Receptor‐interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear.
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
doaj   +1 more source

Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3

FEBS Open Bio, 2020
Smad3 signaling and transgelin expression are often activated during puromycin aminonucleoside (PAN)‐induced podocyte injury. Here, we investigated whether the Smad3 inhibitor SIS3 can ameliorate damage to injured podocytes.
Lina Jiang, Hong Cui, Jie Ding, Aijun Yang, Yingchao Zhang   +4 more
doaj   +1 more source

GAP-43 ameliorates Podocyte injury by decreasing nuclear NFATc1 expression

Biochemistry and Biophysics Reports, 2021
Podocyte injury is sufficient to cause glomerulosclerosis and proteinuria, eventually leading to kidney failure. Previous studies found that podocytes and neurons had similar biological characteristics.
Zhiwen Lian, Guibao Ke, Hong Zhang, Caoshuai Dou, Xueqin Chen, Bohou Li, Fengxia Zhang, Shichun Wen, Qiong Wu, Yubin Xia, Nan Jiang, Zhuo Li, Sijia Li, Xingchen Zhao, Jianchao Ma, Ting Lin, Feng Wen, Lixia Xu, Zhilian Li, Huabang Liang, Wei Dong, Yuanhan Chen, Ruizhao Li, Zhiming Ye, Wenjian Wang, Xinling Liang, Wei Shi, Li Zhang, Shuangxin Liu   +28 more
doaj   +1 more source

Gα12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis [PDF]

, 2012
Glomerulosclerosis is a common pathologic finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well-defined but may include activation of numerous vasoactive and inflammatory pathways.
Beaudry, Sarah, Boucher, Ilene, Denker, Bradley M., Henderson, Joel, Negoro, Hideyuki, Pollak, Martin, Tran, Mei, Yu, Wanfeng   +7 more
core   +1 more source

Urinary detection of podocyte injury

Biomedicine & Pharmacotherapy, 2007
Glomerular epithelial cell (podocyte) biology has been focused on in the last few years. The emerging understanding in podocyte biology has improved the molecular mechanism knowledge in many glomerular diseases. Urinary podocyte count and measurement of urinary podocyte specific markers (nephrin and podocalyxin) have been developed to detect podocyte ...
openaire   +3 more sources