Results 71 to 80 of about 28,951 (302)

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science
Receptor‐interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear.
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
doaj   +1 more source

Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3

FEBS Open Bio, 2020
Smad3 signaling and transgelin expression are often activated during puromycin aminonucleoside (PAN)‐induced podocyte injury. Here, we investigated whether the Smad3 inhibitor SIS3 can ameliorate damage to injured podocytes.
Lina Jiang, Hong Cui, Jie Ding, Aijun Yang, Yingchao Zhang   +4 more
doaj   +1 more source

Gα12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis [PDF]

, 2012
Glomerulosclerosis is a common pathologic finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well-defined but may include activation of numerous vasoactive and inflammatory pathways.
Beaudry, Sarah, Boucher, Ilene, Denker, Bradley M., Henderson, Joel, Negoro, Hideyuki, Pollak, Martin, Tran, Mei, Yu, Wanfeng   +7 more
core   +1 more source

Urinary detection of podocyte injury

Biomedicine & Pharmacotherapy, 2007
Glomerular epithelial cell (podocyte) biology has been focused on in the last few years. The emerging understanding in podocyte biology has improved the molecular mechanism knowledge in many glomerular diseases. Urinary podocyte count and measurement of urinary podocyte specific markers (nephrin and podocalyxin) have been developed to detect podocyte ...
openaire   +4 more sources

Mosaicism of Podocyte Involvement Is Related to Podocyte Injury in Females with Fabry Disease

PLoS ONE, 2014
Fabry disease. an X-linked deficiency of α-galactosidase A coded by the GLA gene, leads to intracellular globotriaosylceramide (GL-3) accumulation. Although less common than in males, chronic kidney disease, occurs in ∼ 15% of females. Recent studies highlight the importance of podocyte injury in Fabry nephropathy development and progression.
Mauer, Michael, Glynn, Emily, Svarstad, Einar, Tøndel, Camilla, Gubler, Marie-Claire, West, Michael, Sokolovskiy, Alexey, Whitley, Chester, Najafian, Behzad   +8 more
openaire   +7 more sources

Podocyte injury associated glomerulopathies induced by pamidronate [PDF]

Kidney International, 2004
Pamidronate has been demonstrated to decrease bone-related complications in multiple myeloma and delay progression of the disease. This has led to its use in supportive and maintenance therapy of myeloma in conjunction with steroids and chemotherapy. It has also been selectively used in patients with breast cancer and other neoplasms.We report on five ...
Yousri M. Barri, Jeffrey Wallach, Nikhil C. Munshi, Suteetat Sukumalchantra, Sameh R. Abul-Ezz, Stephen M. Bonsib, Patrick D. Walker   +6 more
openaire   +3 more sources

Induction of Nephron–Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids

Advanced Healthcare Materials, EarlyView.
A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim, Seeun Kim, Dong Hyun Lee, Dae Hun Kim, Hye Bin Lee, Ye Seul Son, Mi‐Young Son, Soo Jin Oh, Ji‐Yoon Lee, Mi‐Ok Lee, Hyun Soo Cho, Dae‐Soo Kim, Cho‐Rok Jung, Hyun Mi Kang   +13 more
wiley   +1 more source

Role of the podocyte in glomerular injury

Hong Kong Journal of Nephrology, 2001
INTRODUCTION: Appreciation of the important role of the glomerular epithelial cell or podocyte in glomerular physiology and pathology has accelerated in recent years because of advances in two areas. First, detailed study of a number of rare syndromes of earlyonset nephrotic syndrome has led to the identification of key genes whose protein products are
openaire   +2 more sources

Advances in the pathophysiology of pre-eclampsia and related podocyte injury [PDF]

Kidney International, 2014
Pre-eclampsia is a pregnancy-specific hypertensive disorder that may lead to serious maternal and fetal complications. It is a multisystem disease that is commonly, but not always, accompanied by proteinuria. Its cause(s) remain unknown, and delivery remains the only definitive treatment.
Joseph P. Grande, Iasmina M. Craici, Vesna D. Garovic, Tracey L. Weissgerber, Steven J. Wagner   +4 more
openaire   +6 more sources