Results 61 to 70 of about 766,224 (285)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A Dynamically Diluted Alignment Model Reveals the Impact of Cell Turnover on the Plasticity of Tissue Polarity Patterns

, 2017
The polarisation of cells and tissues is fundamental for tissue morphogenesis during biological development and regeneration. A deeper understanding of biological polarity pattern formation can be gained from the consideration of pattern reorganisation ...
Brusch, Lutz, Hoffmann, Karl B., Rink, Jochen C., Voss-Böhme, Anja   +3 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Infants Segment Words from Songs—An EEG Study

Brain Sciences, 2020
Children’s songs are omnipresent and highly attractive stimuli in infants’ input. Previous work suggests that infants process linguistic−phonetic information from simplified sung melodies.
Tineke M. Snijders, Titia Benders, Paula Fikkert   +2 more
doaj   +1 more source

Peak polarity selector Patent [PDF]

, 1970
Peak polarity selector for monitoring ...
Shepard, S. K.
core   +1 more source

Moving Magnetic Features around a Pore

, 2016
Spectropolarimetric observations from Sunrise II/IMaX obtained in June 2013 are used for a statistical analysis to determine the physical properties of moving magnetic features (MMFs) observed near a pore.
Barthol, P., Gandorfer, A., Gizon, L., Hirzberger, J., Iniesta, J. C. Del Toro, Kaithakkal, A. J., Knölker, M., Lagg, A., Pillet, V. Martínez, Riethmüller, T. L., Rodríguez, J. Blanco, Schmidt, W., Solanki, S. K., Suárez, D. Orozco, vanNoort, M.   +14 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14

Cell Reports
Summary: Glioblastoma (GBM), the most aggressive primary brain tumor, is marked by high invasiveness that enables resistance to current therapies. Single-cell RNA sequencing analysis reveals that elevated expression of glial intermediate filament (IF ...
Emma J. van Bodegraven, Elvira Infante, Florent Peglion, David Pereira, Yekta Kesenci, Vanessa Roca, Isabelle Perfettini, Emmanuel Terriac, Juliana Geay, Laura Soto, Jacqueline Sluijs, Reinier Rietveld, Shailaja Seetharaman, Batiste Boëda, Jean-Christophe Olivo-Marin, Atef Asnacios, Aleix Boquet-Pujadas, Jean-Baptiste Manneville, Sandrine Etienne-Manneville   +18 more
doaj   +1 more source

Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements

Cell Division, 2011
Regulation of cytoskeletal remodeling is essential for cell cycle transitions. In fission yeast two NDR kinase signaling cascades, MOR and SIN, regulate the actin cytoskeleton to promote polarized growth during interphase and cytokinesis respectively ...
Gupta Sneha, McCollum Dannel
doaj   +1 more source

Investigating nano-structured domains within ionic liquids: the effect of cation change on thermal equilibrium and relaxation of spiropyran and spirooxazine. [PDF]

, 2009
The established belief that ionic liquids (ILs) behave as homogenous solvents such as that observed in molecular solvents has been challenged.1, 2 Previous use of solvatochromic probe dyes has allowed for the traditional parameter of ‘polarity’ to be ...
Byrne, Robert, Coleman, Simon, Minkovska, Stela   +2 more
core