Results 71 to 80 of about 766,224 (285)
Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. [PDF]
, 2020 Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Choi, Julie +6 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Applying mechanical forces on Drosophila tissues in vivo using the StretchCo, a 3D-printable device
STAR ProtocolsSummary: Applying mechanical forces to tissues helps to understand morphogenesis and homeostasis. Additionally, recording the dynamics of living tissues under mechanical constraints is needed to explore tissue biomechanics. Here, we present a protocol to
Mélanie Gracia +8 more
doaj +1 more source
Political Left and Right: Our Hands-On Logic
Journal of Social and Political Psychology, 2014 The origins and immediate vitality of the left/right divide which emerged in French revolutionary politics from 1789 can only be understood against the background of a much older classification dynamic based on the primacy of the right hand, first ...
Frits Bienfait, Walter E. A. van Beek
doaj +1 more source
, 1976 A photovoltaic cell array consisting of parallel columns of silicon filaments is described. Each fiber is doped to produce an inner region of one polarity type and an outer region of an opposite polarity type to thereby form a continuous radial semi ...
Eliason, J. T.
core +1 more source
Smad4 regulates growth plate matrix production and chondrocyte polarity. [PDF]
, 2017 Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Alliston, Tamara +4 more
core +3 more sources
Supplementary Methods from Novel Mechanism of Tumor Suppression by Polarity Gene <i>Discs Large 1</i> (<i>DLG1</i>) Revealed in a Murine Model of Pediatric B-ALL [PDF]
, 2023 Gabriel J. Sandoval +14 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Seed Morphological Analysis in Species of Vitis and Relatives
HorticulturaeSeed shape descriptions of species of Vitis have traditionally been based on adjectives comparing overall shape with geometric figures, such as oval, elongated oval, and pear-shaped, corresponding to higher values of the Stummer index (lower aspect ratio)
José Javier Martín-Gómez +6 more
doaj +1 more source
IEEE Access, 2016 This paper presents a novel and analytical approach to identifying a lightning strike after it has struck an overhead transmission line. The identification method is mainly based on the traveling waves' time-domain parameters, such as polarity, amplitude,
Yadong Liu +6 more
doaj +1 more source