Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles [PDF]
JACS Au, 2023 Polo-like kinase (Plk4) is a serine/threonine-protein kinase that is essential for biogenesis of the centriole organelle and is enriched at centrioles. Herein, we introduce Cen-TCO, a chemical probe based on the Plk4 inhibitor centrinone, to image Plk4 and centrioles in live or fixed cultured human cells.
Aleksandar Salim +6 more
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Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB) [PDF]
Bioengineering, 2018 Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS).
Anders W. Bailey +7 more
doaj +5 more sources
Role for polo-like kinase 4 in mediation of cytokinesis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 SignificancePolo-like kinase 4 (PLK4), a known cell cycle regulatory protein, localizes to the centrosome during S-phase and facilitates centrosome duplication. We show that phospho-serine305-PLK4 is subsequently redistributed to kinetochores (metaphase and anaphase), midzone during cleavage furrow formation (anaphase and telophase), and midbody ...
Roberta Guzman +2 more
exaly +7 more sources
Autoinhibition and relief mechanism for Polo-like kinase 4 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 SignificancePolo-like kinases (Plks) are a conserved family of enzymes that function as master regulators for the process of cell division. Among their duties, Plks control the assembly of centrosomes, tiny organelles that facilitate mitotic spindle assembly and maintain the fidelity of chromosome inheritance.
Daniel W Buster +2 more
exaly +5 more sources
Polo-like kinase 4: the odd one out of the family [PDF]
Cell Division, 2010 Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj +3 more sources
Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis. [PDF]
PLoS ONE, 2012 Polo-like kinase 4 (PLK4), belonging to serine/threonine kinase family, is critical for centriole replication and cell cycle progression. PLK4 has been proposed as a tumor suppressor in hepatocellular carcinoma (HCC).
Lili Liu +5 more
doaj +4 more sources
Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer [PDF]
Breast, 2021 Development of novel multimodality radiotherapy treatments in metastatic breast cancer, especially in the most aggressive triple negative (TNBC) subtype, is of significant clinical interest. Here we show that a novel inhibitor of Polo-Like Kinase 4 (PLK4)
Armen Parsyan +6 more
doaj +2 more sources
High expression of polo-like kinase 4 predicts worse progression-free survival in diffuse large B cell lymphoma patients treated with R-CHOP [PDF]
World Journal of Surgical OncologyBackground Polo-like kinase 4 (PLK4) has been shown to be a tumor-promoting factor with multiple impacts on cancer growth, invasiveness, and treatment sensitivity.
Dehong Xu +4 more
doaj +2 more sources
Tumor polo-like kinase 4 protein expression reflects lymphovascular invasion, higher Federation of Gynecology and Obstetrics stage, and shortened survival in endometrial cancer patients who undergo surgical resection [PDF]
BMC Women's HealthBackground Polo-like kinase 4 (PLK4) serves as a marker for tumor features and poor outcomes in cancers. This study aimed to explore the associations of tumor PLK4 protein expression with tumor characteristics and survival in endometrial cancer (EC ...
Qinyan Zhao, Minli Wang, Mingcong Chen
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P471: POLO-LIKE KINASE 4 INHIBITION INDUCED ANTI-LEUKAEMIC EFFECTS THROUGH HISTONE MODIFICATION IN TP53 MUTATED ACUTE MYELOID LEUKAEMIA [PDF]
HemaSphere, 2023 Wing Lam +16 more
doaj +2 more sources