Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics. [PDF]
Biochem J, 2020 Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells, since changes in PLK4 concentration and catalysis have profound effects ...
Byrne DP +9 more
europepmc +2 more sources
Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis. [PDF]
PLoS ONE, 2012 Polo-like kinase 4 (PLK4), belonging to serine/threonine kinase family, is critical for centriole replication and cell cycle progression. PLK4 has been proposed as a tumor suppressor in hepatocellular carcinoma (HCC).
Lili Liu +5 more
doaj +1 more source
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. [PDF]
PLoS ONE, 2010 Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells.
Annekatrin Krause, Ingrid Hoffmann
doaj +1 more source
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]
, 2003 We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U. +20 more
core +1 more source
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse [PDF]
Open Biology, 2015 To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4).
Paula A. Coelho +11 more
doaj +1 more source
Autoinhibition and relief mechanism for Polo-like kinase 4. [PDF]
Proc Natl Acad Sci U S A, 2015 Klebba JE +4 more
europepmc +2 more sources
Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
Cells, 2022 Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle.
Ingrid Hoffmann
doaj +1 more source
Cancer Biology & Therapy, 2023 The anti-tumor effect of polo-like kinase 4 (PLK4) inhibitor has been explored in several solid carcinomas, while its application in anaplastic thyroid cancer (ATC) remains scarce.
Wei Zhu, Bin Xie
doaj +1 more source
Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones [PDF]
Pharmaceutical Sciences, 2021 Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment.
Ramesh Sawant +3 more
doaj +1 more source
Structured illumination of the interface between centriole and peri-centriolar material [PDF]
Open Biology, 2012 The increase in centrosome size in mitosis was described over a century ago, and yet it is poorly understood how centrioles, which lie at the core of centrosomes, organize the pericentriolar material (PCM) in this process.
Jingyan Fu, David M. Glover
doaj +1 more source