Results 21 to 30 of about 15,343 (151)

A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition. [PDF]

JACC Basic Transl Sci, 2021
Polo-like kinase 4 (PLK4) is canonically known for its cytoplasmic function in centriole duplication. Here we show a noncanonical PLK4 function of regulating the transcription factor SRF's nuclear activity and associated myofibroblast-like cell-type transition.
Li J, Urabe G, Huang Y, Zhang M, Wang B, Marcho L, Shen H, Kent KC, Guo LW.   +8 more
europepmc   +3 more sources

Polo-like kinase 4 (PLK4) as a therapeutic target in breast cancer. [PDF]

Carcinogenesis
Abstract Polo-like kinase 4 (PLK4) is a key kinase regulating centriole duplication, centrosome maturation, cytokinesis and other cellular processes. Growing evidence suggests a critical role of PLK4 in the development and progression of various cancers.
Parsyan A, Athwal H, Bhat V, Allan AL.
europepmc   +3 more sources

Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication. [PDF]

Genes Dev, 2022
Polo-like kinase 4 (Plk4) is the master regulator of centriole assembly. Several evolutionarily conserved mechanisms strictly regulate Plk4 abundance and activity to ensure cells maintain a proper number of centrioles. In this issue of Genes & Development, Phan et al. (pp.
Ryniawec JM, Rogers GC.
europepmc   +3 more sources

Polo‑like kinase 4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma. [PDF]

Oncol Rep, 2019
Glioblastoma (GBM) is one of the most malignant tumors in adults, associated with severe outcomes (median survival,
Wang J, Zuo J, Wang M, Ma X, Gao K, Bai X, Wang N, Xie W, Liu H.   +8 more
europepmc   +4 more sources

Polo-like Kinase 4 Shapes Up [PDF]

Structure, 2014
Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole ...
Levine, Michelle S., Holland, Andrew J.
openaire   +2 more sources

Polo-like kinase 4 inhibition: a strategy for cancer therapy? [PDF]

Cancer Cell, 2014
In this issue of Cancer Cell, Mason and colleagues describe the development of a Polo-like kinase 4 (PLK4) inhibitor (CFI-400945), with promising activity against tumors formed in mice from patient-derived tumor tissue. A clinical trial has been initiated, but questions remain as to whether PLK4 is the only relevant therapeutic target.
Holland AJ, Cleveland DW.
europepmc   +6 more sources

NFκB regulates expression of Polo-like kinase 4. [PDF]

Cell Cycle, 2013
Activation of the NFκB signaling pathway allows the cell to respond to infection and stress and can affect many cellular processes. As a consequence, NFκB activity must be integrated with a wide variety of parallel signaling pathways. One mechanism through which NFκB can exert widespread effects is through controlling the expression of key regulatory ...
Ledoux AC, Sellier H, Gillies K, Iannetti A, James J, Perkins ND.   +5 more
europepmc   +4 more sources

Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. [PDF]

PLoS ONE, 2010
Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells.
Annekatrin Krause, Ingrid Hoffmann
doaj   +1 more source

Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. [PDF]

Science, 2015
Giving an old organelle the old heave-ho Centrioles are ancient cellular organelles that build centrosomes, the major microtubule-organizing centers in animal cells. Duplication of centrioles is tightly controlled to ensure that each dividing cell has precisely two centrosomes.
Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, Mitchell BJ, Desai A, Gahman TC, Shiau AK, Oegema K.   +14 more
europepmc   +5 more sources

Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4. [PDF]

RSC Chem Biol
Polo-like kinase 4 (PLK4) is a serine/threonine-protein kinase that plays a pivotal role in centriole biogenesis and, as such, represents a master regulator of centriole duplication. Due to its importance in cancer development and progression, PLK4 represents an attractive target for the development of novel therapeutics.
Kovacevic A, Salim A, Borges C, Meraldi P, Hoogendoorn S.   +4 more
europepmc   +2 more sources