Results 41 to 50 of about 15,343 (151)
eLife, 2017 The synaptonemal complex (SC) is an ultrastructurally conserved proteinaceous structure that holds homologous chromosomes together and is required for the stabilization of pairing interactions and the completion of crossover (CO) formation between ...
Saravanapriah Nadarajan +6 more
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Stopping chromosomes from breaking bad
eLife, 2017 The scaffolding that holds chromosome pairs together plays a key role in limiting the levels of double-strand breaks.
Rima Sandhu, G Valentin Börner
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Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability [PDF]
Journal of Cell Biology, 2010 Accurate control of the number of centrosomes, the major microtubule-organizing centers of animal cells, is critical for the maintenance of genome integrity. Abnormalities in centrosome number can promote errors in spindle formation that lead to subsequent chromosome missegregation, and extra centrosomes are found in many cancers.
Holland, Andrew J +4 more
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Molecules, 2020 In the present study, a simple, rapid, and reliable bioanalytical method was developed using liquid chromatography with tandem-mass spectrometry (LC-MS/MS) to quantify 2′,4′,6′-trihydroxyacetophenone (THAP) in rat and dog plasma with 2′,4′,6 ...
Hee Jo Yoo +8 more
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PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
eLife, 2022 Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro +5 more
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Male Hypogonadism and Germ Cell Loss Caused by a Mutation in Polo-Like Kinase 4 [PDF]
Endocrinology, 2011 The genetic etiologies of male infertility remain largely unknown. To identify genes potentially involved in spermatogenesis and male infertility, we performed genome-wide mutagenesis in mice with N-ethyl-N-nitrosourea and identified a line with dominant hypogonadism and patchy germ cell loss.
Rebecca M, Harris +2 more
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Identification of a Polo-like Kinase 4-Dependent Pathway for De Novo Centriole Formation [PDF]
Current Biology, 2011 Supernumerary centrosomes are a key cause of genomic instability in cancer cells. New centrioles can be generated by duplication with a mother centriole as a platform or, in the absence of preexisting centrioles, by formation de novo. Polo-like kinase 4 (Plk4) regulates both modes of centriole biogenesis, and Plk4 deregulation has been linked to tumor ...
Eckerdt, Frank +3 more
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KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number
Molecular & Cellular Oncology, 2017 We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like ...
Marjorie Fournier, László Tora
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Molecular Cancer, 2011 Background Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas.
Duensing Stefan +2 more
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Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source