Results 31 to 40 of about 17,357,527 (148)

Polo-like kinase 4 inhibition: a strategy for cancer therapy? [PDF]

Cancer Cell, 2014
In this issue of Cancer Cell, Mason and colleagues describe the development of a Polo-like kinase 4 (PLK4) inhibitor (CFI-400945), with promising activity against tumors formed in mice from patient-derived tumor tissue.
Holland AJ, Cleveland DW.
europepmc   +2 more sources

On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]

, 2015
Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core   +1 more source

Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.

eLife, 2017
The synaptonemal complex (SC) is an ultrastructurally conserved proteinaceous structure that holds homologous chromosomes together and is required for the stabilization of pairing interactions and the completion of crossover (CO) formation between ...
Saravanapriah Nadarajan, Talley J Lambert, Elisabeth Altendorfer, Jinmin Gao, Michael D Blower, Jennifer C Waters, Monica P Colaiácovo   +6 more
doaj   +1 more source

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]

, 2015
Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Timm Maier, Gabryjonczyk, Anna-Maria, Hiller, Sebastian, Imseng, Stefan, Böhm, Raphael, Maier, Timm, Christian Arquint, Raphael Böhm, Sebastian Hiller, Anna-Maria Gabryjonczyk, Arquint, Christian, Stefan Imseng, Nigg, Erich A., Evelyn Sauer, Erich A Nigg, Sauer, Evelyn   +15 more
core   +1 more source

Stopping chromosomes from breaking bad

eLife, 2017
The scaffolding that holds chromosome pairs together plays a key role in limiting the levels of double-strand breaks.
Rima Sandhu, G Valentin Börner
doaj   +1 more source

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells [PDF]

, 2011
High attrition rates of novel anti-cancer drugs highlight the need for improved models to predict toxicity. Although polo-like kinase 1 (Plk1) inhibitors are attractive candidates for drug development, the role of Plk1 in primary cells remains widely ...
Kappel, Sven, Eckhard Wolf, Kreft, B., Martin Bergmann, Martin Klingenspor, Prinz, Florian, Kurunci-Csacsko, Elisabeth, Nicole Sänger, Knecht, R., Jost Seibler, Thure Adler, Florian Prinz, Strebhardt, K., Hrabě de Angelis, M., Busch, D.H., Monika Raab, Sanhaji, Mourad, Yves Matthess, Martin Hrabě de Angelis, Bergmann, M., Adler, Thure, Seibler, Jost, Rathkolb, Birgit, Irene Esposito, Dirk H. Busch, Rathkolb, B., Rozman, J., Rozman, Jan, Esposito, Irene, Yuan, J., Andrea Krämer, Fuchs, H., Calzada-Wack, Julia, Jan Rozman, Rainald Knecht, Esposito, I., Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Knecht, Rainald, Valérie Gailus-Durner, Wolf, E., Prinz, F., Sänger, Nicole, Krämer, A., Calzada-Wack, J., Gailus-Durner, V., Kappel, S., Helmut Fuchs, Kurunci-Csacsko, E., Klingenspor, Martin, Yuan, Juping, Matthess, Yves, Busch, Dirk H., Klaus Strebhardt, Strebhardt, Klaus, Juping Yuan, Kreft, Bertolt, Julia Calzada-Wack, Sven Kappel, Krämer, Andrea, Klingenspor, M., Matthess, Y., Bergmann, Martin, Birgit Rathkolb, Adler, T., Elisabeth Kurunci-Csacsko, Sänger, N., Raab, Monika, Bertolt Kreft, Fuchs, Helmut, Wolf, Eckhard, Mourad Sanhaji, Raab, M., Sanhaji, M., Seibler, J.   +74 more
core   +1 more source

Tumor inhibition by genomically integrated inducible RNAi-cassettes [PDF]

, 2006
RNA interference (RNAi) has emerged as a powerful tool to induce loss-of-function phenotypes by post-transcriptional silencing of gene expression. In this study we wondered whether inducible RNAi-cassettes integrated into cellular DNA possess the power ...
Kappel, Sven, Zimmer, Brigitte, Brigitte Zimmer, Manfred Kaufmann, Yves Matthess, Matthess, Yves, Klaus Strebhardt, Strebhardt, Klaus, Kaufmann, Manfred   +8 more
core   +1 more source

Development and Validation of an LC-MS/MS Assay to Quantitate 2′,4′,6′-Trihydroxyacetophenone in Rat and Dog Plasma and its Application to a Pharmacokinetic Study

Molecules, 2020
In the present study, a simple, rapid, and reliable bioanalytical method was developed using liquid chromatography with tandem-mass spectrometry (LC-MS/MS) to quantify 2′,4′,6′-trihydroxyacetophenone (THAP) in rat and dog plasma with 2′,4′,6 ...
Hee Jo Yoo, Se-Jung Hwang, Jeong-Hun Lee, Wang-Seob Shim, Yun-Woong Choi, Sang Min Cho, Eun Kyoung Chung, Jun-Bom Park, Kyung-Tae Lee   +8 more
doaj   +1 more source

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

eLife, 2022
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland   +5 more
doaj   +1 more source

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2 [PDF]

, 2004
Mitotic kinases of the Polo and Aurora families are key regulators of chromosome segregation and cytokinesis. Here, we have investigated the role of MKlp1 and MKlp2, two vertebrate mitotic kinesins essential for cytokinesis, in the spatial regulation of ...
Erich A. Nigg, Francis A. Barr, Barr, FA, Neef, Rüdiger, Nigg, EA, Rüdiger Neef, Gruneberg, Ulrike, Honda, R, Ulrike Gruneberg, Nigg, Erich A., Neef, R, Reiko Honda, Honda, Reiko, Barr, Francis A.   +13 more
core   +1 more source