Results 31 to 40 of about 15,343 (151)

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse [PDF]

Open Biology, 2015
To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4).
Paula A. Coelho, Leah Bury, Marta N. Shahbazi, Kifayathullah Liakath-Ali, Peri H. Tate, Sam Wormald, Christopher J. Hindley, Meritxell Huch, Joy Archer, William C. Skarnes, Magdalena Zernicka-Goetz, David M. Glover   +11 more
doaj   +1 more source

Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer

Cells, 2022
Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle.
Ingrid Hoffmann
doaj   +1 more source

Targeting the centrosome and polo-like kinase 4 in osteosarcoma

Carcinogenesis, 2018
It has been historically uncertain if extra centrosomes are a cause or consequence of tumorigenesis. Experiments have recently established that overexpression of polo-like kinase 4 (PLK4) promotes centrosome amplification with consequential promotion of cellular aneuploidy. Furthermore, centrosome amplification drives spontaneous tumorigenesis in mice.
Fergal C, Kelleher, Jeska, Kroes, Jeremy, Lewin   +2 more
openaire   +2 more sources

Autophosphorylation of Polo-like Kinase 4 and Its Role in Centriole Duplication [PDF]

Molecular Biology of the Cell, 2010
Centrosome duplication occurs once every cell cycle in a strictly controlled manner. Polo-like kinase 4 (PLK4) is a key regulator of this process whose kinase activity is essential for centriole duplication. Here, we show that PLK4 autophosphorylation of serine S305 is a consequence of kinase activation and enables the active fraction to be identified ...
Sillibourne, James E., Tack, Frederik, Vloemans, Nele, Boeckx, An, Thambirajah, Sathiesan, Bonnet, Pascal, Ramaekers, Frans C. S., Bornens, Michel, Grand-Perret, Thierry   +8 more
openaire   +3 more sources

PLK4 inhibitor exhibits antitumor effect and synergizes sorafenib via arresting cell cycle and inactivating Wnt/β-catenin pathway in anaplastic thyroid cancer

Cancer Biology & Therapy, 2023
The anti-tumor effect of polo-like kinase 4 (PLK4) inhibitor has been explored in several solid carcinomas, while its application in anaplastic thyroid cancer (ATC) remains scarce.
Wei Zhu, Bin Xie
doaj   +1 more source

Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones [PDF]

Pharmaceutical Sciences, 2021
Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment.
Ramesh Sawant, Jyoti Wadekar, Rushikesh Ukirde, Ganesh Barkade   +3 more
doaj   +1 more source

Structured illumination of the interface between centriole and peri-centriolar material [PDF]

Open Biology, 2012
The increase in centrosome size in mitosis was described over a century ago, and yet it is poorly understood how centrioles, which lie at the core of centrosomes, organize the pericentriolar material (PCM) in this process.
Jingyan Fu, David M. Glover
doaj   +1 more source

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition. [PDF]

Proc Natl Acad Sci U S A, 2018
In “CFI-400945 is not a selective cellular PLK4 inhibitor,” Oegema et al. (1) raise thoughtful comments about our article (2). We appreciate their interest and critique. They propose that CFI-400945 activity was not from Polo-like kinase (PLK4) inhibition and argue that antineoplastic activity was through Aurora B kinase (1), rather than PLK4 ...
Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E.   +15 more
europepmc   +4 more sources

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance Despite current treatments, lung cancers remain a major public health problem. Innovative ways are needed to treat or prevent these cancers. Centrosomes are critical for fidelity of mitosis. Abnormal centrosome numbers can cause aberrant mitosis and cell death.
Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E.   +15 more
europepmc   +4 more sources

Polo-like Kinase 4 Autodestructs by Generating Its Slimb-Binding Phosphodegron [PDF]

Current Biology, 2013
Polo-like kinase 4 (Plk4) is a conserved master regulator of centriole assembly. Previously, we found that Drosophila Plk4 protein levels are actively suppressed during interphase. Degradation of interphase Plk4 prevents centriole overduplication and is mediated by the ubiquitin-ligase complex SCF(Slimb/βTrCP).
Klebba, Joseph E., Buster, Daniel W., Nguyen, Annie L., Swatkoski, Stephen, Gucek, Marjan, Rusan, Nasser M., Rogers, Gregory C.   +6 more
openaire   +2 more sources