Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source
Controversies and clinical unknowns in the use of PARP inhibitors in ovarian cancer
Therapeutic Advances in Medical OncologyPoly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have significantly improved the treatment of advanced ovarian cancer, however, there are still many aspects of their use that require further understanding.
Uma A. Mukherjee +2 more
doaj +1 more source
Interaction of Nucleosides and Related Compounds with Nucleic Acids as Indicated by the Change of Helix-Coil Transition Temperature [PDF]
, 1962 A series of compounds has been tested for effectiveness in lowering the melting temperature of poly A and of thymus DNA. The order of increasing activity was found to be: adonitol, methyl riboside (both negligible) < cyclohexanol < phenol, pyrimidine ...
Helmkamp, G. K. +2 more
core +1 more source
Targeting Genome Maintenance Defects of Cancers Using Chain‐Terminating Nucleoside Analogs
Cancer Science, Volume 117, Issue 3, Page 587-596, March 2026.Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Ryotaro Kawasumi +2 more
wiley +1 more source
Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia [PDF]
, 2005 Drug resistance in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) is associated with impaired ability to induce apoptosis.
Bergh, A.R.M. (Anne) von +6 more
core +3 more sources
NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn +10 more
wiley +1 more source
Hepatitis C Virus Nonstructural 5A Protein Inhibits Lipopolysaccharide-Mediated Apoptosis of Hepatocytes by Decreasing Expression of Toll-Like Receptor 4 [PDF]
, 2017 Background. Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to modulate multiple cellular processes, including apoptosis. The aim of this study was to assess the effects of HCV NS5A on apoptosis induced by Toll-like receptor (TLR ...
Arai, Makoto +12 more
core
Triple negative breast cancer: new perspectives for targeted therapies [PDF]
, 2015 Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide +8 more
core +1 more source
The effect of time on associations between historical redlining and breast cancer survival
Cancer, Volume 132, Issue 4, 15 February 2026.Abstract Background Historical redlining, a 1930s residential segregation policy, has been associated with shorter breast cancer survival. It is unknown whether this disparity has changed over time, given the time since redlining increases and subsequent breast cancer advances have occurred.
Sarah M. Lima +8 more
wiley +1 more source
From mechanism to phenotype: What fits in a basket trial
Epilepsia, EarlyView.
Kette D. Valente
wiley +1 more source