Results 151 to 160 of about 15,233 (264)
Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley +1 more source
Poly(ADP-ribose) polymerases as modulators of mitochondrial activity [PDF]
, 2019 Bai, Péter +4 more
core +1 more source
Characterization of the five replication factor C genes of Saccharomyces cerevisiae [PDF]
, 1995 Replication factor C (RFC) is a five-subunit DNA polymerase accessory protein that functions as a structure-specific, DNA-dependent ATPase. The ATPase function of RFC is activated by proliferating cell nuclear antigen.
Cullmann, G. +3 more
core
The Prostate, Volume 86, Issue 6, Page 727-731, May 2026.ABSTRACT Background Methyl Methanesulfonate‐Sensitivity Protein 22‐Like (MMS22L) plays a key role in homology‐directed DNA repair, and experimental models have shown that its loss confers sensitivity to Poly (ADP‐ribose) polymerase inhibitors (PARPi).
Mayuko Kanayama +12 more
wiley +1 more source
Poly(ADP-Ribose) Polymerases in Plants and Their Human Counterparts: Parallels and Peculiarities. [PDF]
Int J Mol Sci, 2019 Rissel D, Peiter E.
europepmc +1 more source
The Prostate, Volume 86, Issue 6, Page 689-696, May 2026.ABSTRACT Background In prostate cancer (PCa), smoking history is associated with more aggressive clinicopathological features, reduced efficacy of androgen deprivation therapy, and poorer overall survival (OS). However, its impact on survival outcomes in patients receiving taxane chemotherapy, poly ADP‐ribose polymerase inhibitor (PARPi), or immune ...
Tomoya Hatayama +16 more
wiley +1 more source
The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia +4 more
wiley +1 more source
Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity. [PDF]
Microbiol Mol Biol Rev, 2019 Brady PN, Goel A, Johnson MA.
europepmc +1 more source
Advanced Science, Volume 13, Issue 19, 2 April 2026.Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan +12 more
wiley +1 more source
Correction for Brady et al., "Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity". [PDF]
Microbiol Mol Biol Rev, 2019 Brady PN, Goel A, Johnson MA.
europepmc +1 more source