Results 151 to 160 of about 9,722 (255)
Experimental Physiology, EarlyView.Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves +3 more
wiley +1 more source
Intramuscular pathways of maladaptation in overtraining syndrome
The Journal of Physiology, EarlyView.Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter +4 more
wiley +1 more source
Proteomique fonctionnelle des poly(ADP-Ribose) polymerases
, 2018 L'ADN, support de l'information génétique, subit chaque jour de nombreuses attaques pouvant induire différents types de lésions. Que ce soit d'origine environnementale (agents chimiques), rayonnements ionisants) ou d'origine endogène (métabolisme de L ...
Moreel, Xavier
core
Olaparib‐associated cutaneous vasculitis in a patient with breast cancer
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Marcial Álvarez‐Salafranca +3 more
wiley +1 more source
Biomedical Chromatography, Volume 40, Issue 8, August 2026.ABSTRACT Olaparib belongs to the PARP inhibitors and is widely used as an anticancer drug. Due to frequent side effects, it is usually co‐administered with an antihypertensive, such as propranolol and/or an antidiuretic, such as furosemide. In this study, a highly sensitive HPLC‐FLD method was developed for the simultaneous determination of the three ...
Georgios Kamaris +2 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 3, Page 719-728, 1 August 2026.What's New? The emerging role of immunotherapy in small‐cell lung cancer treatment has not been fully elucidated, particularly outside of clinical trials. This single‐center retrospective cohort study examined real‐world treatment patterns and overall survival in South Korea during the 2018–2023 period.
Sehhoon Park +11 more
wiley +1 more source
Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis
British Journal of Pharmacology, Volume 183, Issue 15, Page 4126-4144, August 2026.Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan +17 more
wiley +1 more source
Correction for Brady et al., "Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity". [PDF]
Microbiol Mol Biol Rev, 2019 Brady PN, Goel A, Johnson MA.
europepmc +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source