Results 171 to 180 of about 15,233 (264)
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 4, April 2026.The anticancer activity of 5‐FU modified with mannose containing 1,2,3‐triazole compound in MCF‐7 breast cancer cells were revealed in this study. While 5‐FU caused cytotoxicity in both cancerous and healthy cells, 5‐FUD‐Man showed selective cytotoxicity.
Ebru Şanci +7 more
wiley +1 more source
Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro. [PDF]
Nucleic Acids Res, 2016 Talhaoui I +10 more
europepmc +1 more source
The Flavivirus NS3 Protein: Its Multifaceted Roles and Therapeutic Potential
Journal of Medical Virology, Volume 98, Issue 4, April 2026.Abstract Mosquito‐borne flaviviruses are important human pathogenic viruses and can cause an array of symptoms ranging from asymptomatic to mild illness but can progress to severe disease conditions. Prominent members of the family Flaviviridae include Dengue virus, Zika virus, and West Nile virus, whose spread has increased globally due to the ...
Haejeong Lee, Hee Cho, Michaela U. Gack
wiley +1 more source
MedComm, Volume 7, Issue 4, April 2026.This phase II trial evaluated the efficacy and safety of niraparib combined with HX008 in metastatic breast cancer (MBC) patients with germline DNA damage response (DDR) gene mutations. This chemotherapy‐free regimen demonstrates promising efficacy and a tolerable safety profile in MBC patients with germline DDR mutations, providing a novel therapeutic
Jian Zhang +9 more
wiley +1 more source
MedComm, Volume 7, Issue 4, April 2026.SFN sensitizes PD‐1 blockade therapy in preclinical and clinical investigations, with no side effects. SFN elevates the antitumor response in peripheral and tumor microenvironment. ABSTRACT Anti‐PD‐1/PD‐L1 therapy has achieved promising success across several tumor types; however, its efficacy is still far from satisfactory in non–small cell lung ...
Jieyao Li +16 more
wiley +1 more source
System level network data and models attack cancer drug resistance
British Journal of Pharmacology, Volume 183, Issue 8, Page 1640-1652, April 2026.Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély +6 more
wiley +1 more source
No Silver Bullet - Canonical Poly(ADP-Ribose) Polymerases (PARPs) Are No Universal Factors of Abiotic and Biotic Stress Resistance of Arabidopsis thaliana. [PDF]
Front Plant Sci, 2017 Rissel D +5 more
europepmc +1 more source