Results 181 to 190 of about 15,233 (264)

Another TRP to endothelial dysfunction [PDF]

, 2008
Dietrich, Alexander, Gudermann, Thomas
core   +1 more source

Novel Silver(I) and Gold(I) N‐Heterocyclic Carbene Complexes Induce ROS‐Dependent Autophagic Cell Death in Human Hepatoma Cell Line HepG2

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
In this research work, the cytotoxicity of eight sulfonated silver(I) and gold(I) N‐heterocyclic carbene (NHC) complexes—four newly synthesized—was evaluated against human liver cancer cells. Two compounds showed selectivity for cancer cells, inducing ROS‐dependent autophagic cell death via AKT/mTOR pathway inhibition without triggering apoptosis ...
Rocchina Miglionico, Francesco Viceconte, Maria Francesca Armentano, Annaluisa Mariconda, Ilaria Nigro, Pasquale Longo, Faustino Bisaccia   +6 more
wiley   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, Volume 158, Issue 6, Page 1617-1627, 15 March 2026.
What's new? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases. [PDF]

Chem Rev, 2015
Ryu KW, Kim DS, Kraus WL.
europepmc   +1 more source

Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways. [PDF]

DNA Repair (Amst), 2016
Ghosh R, Roy S, Kamyab J, Danzter F, Franco S.   +4 more
europepmc   +1 more source

Role of poly(ADP-ribose) polymerases in male reproduction. [PDF]

Spermatogenesis, 2013
Celik-Ozenci C, Tasatargil A.
europepmc   +1 more source

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. [PDF]

Cell Metab, 2014
Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J.   +21 more
europepmc   +1 more source

[Role of poly(ADP-ribose) polymerases-1-mediated blockade of autophagy in ischemia/reperfusion injury of rat cardiomyocytes]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2018
Zhao W, Wang Y, Wei G, Xu S.
europepmc   +1 more source

Metabolism and Congenital Malformations — NAD’s Effects on Development [PDF]

, 2017
Vander Heiden, Matthew G.
core   +1 more source