Results 181 to 190 of about 39,389 (304)
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source
Effects of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis
Akbar Ahmad +10 more
openalex +2 more sources
Two Proteolytic Degradation Products of Calf‐Thymus Poly(ADP‐ribose) Polymerase Are Efficient ADP‐ribose Acceptors [PDF]
Jostein Holtlund +2 more
openalex +1 more source
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
ABSTRACT Purpose Genetic testing is recommended but underutilized in advanced prostate cancer. Given known disparities affecting Black patients, we assessed genetic testing completion rates by race. Methods Henry Ford Health's electronic medical record was queried for new prostate cancer diagnoses (1/1/2017–6/30/2022).
Kyle C. McElyea +7 more
wiley +1 more source

