Results 211 to 220 of about 15,233 (264)
The nicotinamide hypothesis revisited-plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione. [PDF]
FEBS LettBerglund T, Ohlsson AB.
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Global research trends in PARP inhibitors for ovarian cancer: a bibliometric analysis. [PDF]
Discov OncolWang X, Ding G, He J, Huang Y, Wang Q.
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Synthesis of Novel Substituted <i>N</i>‑Heterocycles and Their Use of Selective Poly(ADP-ribose) Polymerase 1 (PARP1) Inhibitors. [PDF]
ACS Med Chem LettZhou X, Liang SH.
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Metabolites beyond metabolism: Exploring their atypical roles in protein modification and signaling transduction. [PDF]
Chin Med J (Engl)Yang W, Wu J, Cui G.
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PARP Inhibition Shifts Murine Myeloid Cells Toward a More Tolerogenic Profile In Vivo. [PDF]
BiomoleculesPittaluga-Villarreal JR +5 more
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Poly(ADP-Ribose) Polymerase Inhibitors
Current Medicinal Chemistry, 2003Poly(ADP-ribose) polymerase-1 (PARP-1) is the principal member of the PARP enzyme family consisting of PARP-1 and several recently identified novel poly(ADP-ribosyl)ating enzymes. PARP-1 functions as a DNA damage sensor and signalling molecule. Upon binding to DNA breaks, activated PARP cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes ...
Garry J, Southan, Csaba, Szabó
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Trapping Poly(ADP-Ribose) Polymerase
The Journal of Pharmacology and Experimental Therapeutics, 2015Recent findings indicate that a major mechanism by which poly(ADP-ribose) polymerase (PARP) inhibitors kill cancer cells is by trapping PARP1 and PARP2 to the sites of DNA damage. The PARP enzyme-inhibitor complex "locks" onto damaged DNA and prevents DNA repair, replication, and transcription, leading to cell death.
Yuqiao, Shen +2 more
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Poly (ADP-ribose) polymerase 1
2022Poly (ADP-ribose) polymerase 1 is a key player in DNA repair and transcription regulation. The role of PARP1 in DNA damage recognition and protein signaling in response make it integral to genome stability. Beyond this, it regulates gene expression through chromatin remodeling and transcription factor binding.
Fletcher E Bain +6 more
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