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Activity Assays for Poly-ADP Ribose Polymerase
2004Poly(ADP-ribose) polymerase (PARP-1) is a nuclear enzyme that has traditionally been thought to require discontinuous or "damaged" DNA (dcDNA) as a coenzyme, a preconception that has limited research mainly to its role in cell pathology, i.e., DNA repair and apoptosis.
Eva, Kirsten +3 more
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The Histochemical Journal, 1996
Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper +3 more
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Poly(ADP-ribose) polymerase catalyses the formation of ADP-ribose polymers covalently attached to various nuclear proteins, using NAD+ as substrate. The activity of this enzyme is strongly stimulated upon binding to DNA single or double strand breaks. Poly(ADP-ribosyl)ation is an immediate cellular response to DNA damage and is thought to be involved ...
J H, Küpper +3 more
openaire +2 more sources
Poly(ADP-ribose) polymerase and aging
2001Publisher Summary Poly(ADP-ribose) polymerase (PARP) is a major nuclear protein associated with chromatin that contains zinc fingers and binds to either double- or single-strand DNA breaks. Upon binding to DNA, PARP is activated and forms covalent homopolymers of poly(ADP-ribose) (PAR) attached to a number of nuclear proteins, including itself and ...
Dean S. Rosenthal +3 more
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Inhibition of poly(ADP-ribose) polymerase in cancer
Current Opinion in Pharmacology, 2006Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) has been extensively investigated in the pre-clinical setting as a strategy for chemo- or radio-potentiation. Recent evidence has suggested that PARP inhibitors might be active as single agents in certain rare inherited cancers that carry DNA repair defects.
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Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
Nature Reviews Molecular Cell Biology, 2021Lori Anne Passmore, Jeff Coller
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Poly(ADP-ribose) polymerase inhibition: past, present and future
Nature Reviews Drug Discovery, 2020Nicola J Curtin, Csaba Szabo
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Poly(N-isopropylacrylamide)-based smart hydrogels: Design, properties and applications
Progress in Materials Science, 2021Ling Wang, Xiao Yang, Yiyu Feng
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