Results 101 to 110 of about 6,764 (212)

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. [PDF]

, 2015
BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell ...
Aittomäki, Kristiina, Alnæs, Grethe G, Behrens, Sabine, Blomqvist, Carl, Bolla, Manjeet K., Børresen-Dale, Anne-Lise, Chang-Claude, Jenny, Couch, Fergus J., Dunning, Alison M., Easton, Doug F, Fagerholm, Rainer, Flesch-Janys, Dieter, Hall, Per, Hamann, Ute, Hartikainen, Jaana M., Hollestelle, Antoinette, Hooning, Maartje J, Humphreys, Keith, Jager, Agnes, Kabisch, Maria, Kataja, Vesa, Kosma, Veli-Matti, Kristensen, Vessela, Lambrechts, Diether, Li, Jingmei, Liu, Jianjun, Mannermaa, Arto, Margolin, Sara, Michailidou, Kyriaki, Nevanlinna, Heli, Nord, Silje, Pharoah, Paul, Popanda, Odilia, Purrington, Kristen S, Rhenius, Valerie, Schildkraut, Joellen M, Schmezer, Peter, Schmidt, Marjanka K., Seibold, Petra, Seynaeve, Caroline, Shah, Mitul, Torres, Diana, Ulmer, Hans-Ulrich, Wang, Qin, Wildiers, Hans   +44 more
core   +4 more sources

The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus

Challenges, 2018
The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
doaj   +1 more source

Structural Implications for Selective Targeting of PARPs. [PDF]

, 2013
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD(+) as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins.
Armen, MD, Roger S, Brody, MD, Jonathan, Pascal, MD, John M, Steffen, MD, Jamin D   +3 more
core   +3 more sources

The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]

, 2015
The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika, Nikiforov, Andrey, Ziegler, Mathias   +2 more
core   +2 more sources

Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors [PDF]

, 2017
The majority of pancreatic ductal adenocarcinomas (PDAC) rely on the mRNA stability factor HuR (ELAV-L1) to drive cancer growth and progression. Here, we show that CRISPR-Cas9–mediated silencing of the HuR locus increases the relative sensitivity of PDAC
Brody, Jonathan R., Chand, Saswati N., Cozzitorto, Joseph A., Jiang, Wei, Knudsen, Karen E., Lal, Shruti, Londin, Eric R., Meisner-Kober, Nicole, Nevler, Avinoam, Pascal, John M, Pishvaian, Michael J., Romeo, Carmella, Sanan, Akshay R., Schiewer, M. J., Scolaro, Laura, Winter, Jordan M., Yeo, Charles, Zarei, Mahsa   +17 more
core   +1 more source

Proximity in chromatin : opportunities for innovations [PDF]

, 2014
Mammalian chromosomes extensively communicate with each other via long-range chromatin interactions. These interactions are mostly mediated by proteins, which work as teams to control genes in the cells.
Yammine, Samer
core   +1 more source

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment. [PDF]

Commun Biol, 2023
Maresca C, Dello Stritto A, D'Angelo C, Petti E, Rizzo A, Vertecchi E, Berardinelli F, Bonanni L, Sgura A, Antoccia A, Graziani G, Biroccio A, Salvati E.   +12 more
europepmc   +1 more source

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage

BMC Plant Biology, 2019
Background Poly (ADP-ribosyl) ation (PARylation) is an important posttranslational modification that regulates DNA repair, gene transcription, stress responses and developmental processes in multicellular organisms.
Zongying Gu, Weiyang Pan, Wei Chen, Qichao Lian, Qiao Wu, Zeyu Lv, Xuan Cheng, Xiaochun Ge   +7 more
doaj   +1 more source

Poly(ADP-ribosyl) polymerase in life and death of neural cells [PDF]

, 2014
Poli(ADP riboza) je post-translacijska modifikacija proteina koju iz NAD+ sintetiziraju proteini iz obitelji Poli(ADP-ribozil) polimeraza. Poli(ADP-ribozil)acija je reverzibilna reakcija te povratnu reakciju katalizira nekolicina specifičnih enzima. Poli(
Ahel, Josip
core   +2 more sources

PARP-1 regulates DNA repair factor availability. [PDF]

, 2018
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth, Brand, Lucas J, Cendon-Florez, Ylenia, Chand, Saswati N., de Leeuw, Renée, Dicker, Adam, MD, PhD, Dylgjeri, Emanuela, Evans, Joseph, Feng, Felix Y, Gallagher, Peter, Gaur, Sanchaika, Gomella, Leonard G, Gordon, Nicolas, Han, Sumin, Huang, Fangjin, Kelly, William Kevin, Knudsen, Beatrice, Knudsen, Karen E, Lallas, Costas D, Leiby, Benjamin E, Mandigo, Amy C., McCann, Jennifer J, McCue, Peter, McNair, Christopher, Parsons, Theodore, Poudel Neupane, Neermala, Raj, Ganesh V, Schiewer, M J, Shafi, Ayesha A, Trabulsi, Edouard J, Visakorpi, Tapio, Zhao, Shuang G   +31 more
core   +2 more sources