Results 41 to 50 of about 6,764 (212)

3-Aminobenzamide Blocks MAMP-Induced Callose Deposition Independently of Its Poly(ADPribosyl)ation Inhibiting Activity

Frontiers in Plant Science, 2018
Cell wall reinforcement with callose is a frequent plant response to infection. Poly(ADP-ribosyl)ation is a protein post-translational modification mediated by poly(ADP-ribose) polymerases (PARPs).
Brian D. Keppler, Junqi Song, Jackson Nyman, Christian A. Voigt, Andrew F. Bent   +4 more
doaj   +1 more source

DNA damage repair protein PARP1 poly (ADP-ribosyl) ates mitotic protein BUB3 regulates mitosis in HeLa cells

陆军军医大学学报, 2023
Objective To investigate the role and molecular mechanism of poly (ADP-ribose) polymerase 1 (PARP1) in mitosis of HeLa cells. Methods Flow cytometry, immunofluorescent assay and live cell imaging were used to detect the effect of PARP1 on mitosis of HeLa
YANG Xue, YANG Xue, YANG Xue, XU Bo, XU Bo, XU Bo   +5 more
doaj   +1 more source

Synergistic cytotoxicity of fludarabine, clofarabine, busulfan, vorinostat and olaparib in AML cells

Frontiers in Oncology, 2023
Combinations of nucleoside analog(s) and DNA alkylating agent(s) are used for cancer treatment as components of pre-transplant regimens used in hematopoietic stem cell transplantation.
Benigno C. Valdez, Bin Yuan, David Murray, Jeremy Leon Ramdial, Yago Nieto, Uday Popat, Xiaowen Tang, Borje S. Andersson   +7 more
doaj   +1 more source

DNA methylation and chromatin structure: The puzzling CpG islands [PDF]

, 2005
DNA methylation is the epigenetic modification,which introduces 5mC as fifth base onto DNA. As for the distribution of 5rnCs, it is well known that they distribute themselves in a non-random fashion in genomic DNA so that methylation pattern is ...
CAIAFA, Paola, ZAMPIERI, Michele
core   +1 more source

Molecular Insights into Poly(ADP-ribose) Recognition and Processing

Biomolecules, 2012
Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel, Eva Barkauskaite, Roko Žaja, Andreja Mikoč   +3 more
doaj   +1 more source

The C-Terminal Domain of Y-Box Binding Protein 1 Exhibits Structure-Specific Binding to Poly(ADP-Ribose), Which Regulates PARP1 Activity

Frontiers in Cell and Developmental Biology, 2022
Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in the regulation of gene expression. Recent studies showed that in addition to its role in the RNA and DNA metabolism, YB-1 is involved in the regulation of PARP1 activity, which ...
Konstantin N. Naumenko, Mariya V. Sukhanova, Loic Hamon, Tatyana A. Kurgina, Tatyana A. Kurgina, Rashid O. Anarbaev, Rashid O. Anarbaev, Aswin Mangerich, David Pastré, Olga I. Lavrik, Olga I. Lavrik   +10 more
doaj   +1 more source

ARH Family of ADP-Ribose-Acceptor Hydrolases

Cells, 2022
The ARH family of ADP-ribose-acceptor hydrolases consists of three 39-kDa members (ARH1-3), with similarities in amino acid sequence. ARH1 was identified based on its ability to cleave ADP-ribosyl-arginine synthesized by cholera toxin.
Hiroko Ishiwata-Endo, Jiro Kato, Sachiko Yamashita, Chanbora Chea, Kazushige Koike, Duck-Yeon Lee, Joel Moss   +6 more
doaj   +1 more source

Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle [PDF]

, 2018
Poly(ADP-ribosyl)ation (PAR) is a post-translational protein modification catalysed by enzyme member of the poly(ADP-ribose) polymerases (PARPs) family. The activation of several PARPs is triggered by DNA strand breakage and the main PARP enzyme involved
Buttazzoni, Luca, De Matteis, Giovanna, Grandoni, Francesco, Meyer, Ralph G., Meyer-Ficca, Mirella L., Moioli, Bianca, Reale, Anna, Scatà, Maria Carmela   +7 more
core   +1 more source

Regulation of mitosis by poly(ADP-ribosyl)ation [PDF]

Biochemical Journal, 2005
The spindle is a dynamic, microtubule-based structure responsible for chromosome segregation during cell division. Spindles in mammalian cells contain several thousand microtubules that are arranged into highly symmetric bipolar arrays by the actions of numerous microtubule-associated motor and non-motor proteins.
openaire   +2 more sources

Parp3 assists muscle function and skeletal muscle differentiation by selectively adjusting H3K27me3 enrichment

iScience
Summary: Poly(ADP-ribose) polymerase 3 (Parp3) is known for its role in DNA repair, mitotic division, and cancer aggressiveness. Still, its physiological roles have yet to be defined.
Zuleyha Yildirim, Aurélia Noll, Kathline Martin-Hernandez, Jean-Christophe Amé, Najat Hanini, Nadia Messaddeq, Isabelle Robert, Bernardo Reina San Martin, Gunn Hildrestrand, Magnar Bjoras, Françoise Dantzer   +10 more
doaj   +1 more source