Results 51 to 60 of about 6,764 (212)

Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]

, 2011
Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
core  

Mammalian Spermatogenesis, DNA Repair, Poly(ADP-ribose) Turnover: the State of the Art [PDF]

, 2011
DNA repair and poly(ADP-ribosyl)ation system during spermatogenesis under physiological and pathological conditions
Faraone Mennella, Maria Rosaria
core   +1 more source

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation [PDF]

Nature Genetics, 2004
Chromatin insulators demarcate expression domains by blocking the cis effects of enhancers or silencers in a position-dependent manner. We show that the chromatin insulator protein CTCF carries a post-translational modification: poly(ADP-ribosyl)ation.
Wenqiang, Yu, Vasudeva, Ginjala, Vinod, Pant, Igor, Chernukhin, Joanne, Whitehead, France, Docquier, Dawn, Farrar, Gholamreza, Tavoosidana, Rituparna, Mukhopadhyay, Chandrasekhar, Kanduri, Mitsuo, Oshimura, Andrew P, Feinberg, Victor, Lobanenkov, Elena, Klenova, Rolf, Ohlsson   +14 more
openaire   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response [PDF]

, 2012
Poly(ADP-ribose) polymerases (PARPs; also known as ADP-ribosyl transferase D proteins) modify acceptor proteins with ADP-ribose modifications of varying length (reviewed in refs 1, 2, 3). PARPs regulate key stress response pathways, including DNA damage
A Bertolotti, AK Leung, BD Hamman, C Sidrauski, D Ron, E Pedrazzini, H Harding, H Kleine, H Lorenz, HP Harding, I Kim, J Ménissier-de Murcia, JD Malhotra, L Zheng, M Calfon, M Malanga, M Schuldiner, Miri Jwa, MO Hottiger, N Borgese, P Chang, P Walter, P Whitley, Paul Chang, PO Hassa, R Sriburi, S Di Paola, SB Stephens, V Schreiber, Y Kimata   +29 more
core   +1 more source

In vitro poly(ADP-ribosyl)ation of seminal ribonuclease.

Journal of Biological Chemistry, 1986
The site of in vitro ADP-ribosylation of seminal ribonuclease was determined. Seminal enzyme was found to be a good receptor of [14C]ADP-ribose residues under the reaction conditions used. The recovery of [14C]ADP-ribosylated RNase was about 65% after purification.
H. SUZUKI, P. QUESADA, FARINA, BENEDETTA, E. LEONE   +3 more
openaire   +4 more sources

New readers and interpretations of poly(ADP-ribosyl)ation [PDF]

Trends in Biochemical Sciences, 2012
Poly(ADP-ribosyl)ation (PARylation), a protein post-translational modification that was originally connected to the DNA damage response, is now known to engage in a continuously increasing number of biological processes. Despite extensive research and ceaseless, important findings about its role and mode of action, poly(ADP-ribose) remains an enigma ...
Kalisch, Thomas, Amé, Jean-Christophe, Dantzer, Françoise, Schreiber, Valérie   +3 more
openaire   +3 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

S100B impairs glycolysis via enhanced poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells [PDF]

, 2017
S100 calcium-binding protein B (S100B), a multifunctional macromolecule mainly expressed in nerve tissues and adipocytes, has been suggested to contribute to the pathogenesis of obesity.
73761, 73762, 73763, 73764, 73765, 73766, 73767, 73768, 73769, 73770, Arima, Hiroshi, Fujiya, Atsushi, Hamada, Yoji, Hosokawa, Kaori, Izumoto, Takako, Maekawa, Ryuya, Murase, Masatoshi, Niwa, Yasuhiro, Seino, Yusuke, Tsunekawa, Shin   +19 more
core   +1 more source

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source