Results 61 to 70 of about 6,764 (212)

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Poly(ADP-ribose) Polymerase-1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Potential [PDF]

, 2014
Poly(ADP-ribosyl)ation reactions, carried out by poly(ADP-ribose) polymerases (PARPs/ARTDs), are reversible posttranslational modifications impacting on numerous cellular processes (e.g., DNA repair, transcription, metabolism, or immune functions). PARP1
Bay, Péter, Little, P., Liu, P., Xu, S.
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, Volume 600, Issue 4, Page 418-438, February 2026.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Redox Biology, 2021
Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients.
Juan Manuel Martí, Angel Garcia-Diaz, Daniel Delgado-Bellido, Francisco O'Valle, Ariannys González-Flores, Onintza Carlevaris, José Manuel Rodríguez-Vargas, Jean Christophe Amé, Françoise Dantzer, George L. King, Klaudia Dziedzic, Edurne Berra, E. de Álava, A.T. Amaral, Ester M. Hammond, F. Javier Oliver   +15 more
doaj   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

Translational Oncology, 2022
The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear.
Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li   +4 more
doaj   +1 more source

PARP-3 and APLF function together to accelerate nonhomologous end joining [PDF]

, 2010
PARP-3 is a member of the ADP-ribosyl transferase superfamily of unknown function. We show that PARP-3 is stimulated by DNA double-strand breaks (DSBs) in vitro and functions in the same pathway as the poly (ADP-ribose)-binding protein APLF to accelerate
Ahel, Ame, Anna E.O. Fisher, Audebert, Bekker-Jensen, Benjamin, Bernardo Reina-San-Martin, Boulton, Brown, Bryant, Bryant, Caldecott, Caldecott, Critchlow, Ding, Drouet, El-Khamisy, Farmer, Fisher, Grawunder, Guy Poirier, Hochegger, Hottiger, Iles, Isabelle Robert, Kanno, Keith W. Caldecott, Kickhoefer, Kleine, Le Page, Lehtio, Limei Ju, Lobrich, Loseva, Macrae, Mahaney, Maria C. Zuma, Mehrotra, Michele Rouleau, Morrison, Okano, Otto, Poirier, Robert, Roberts, Rogakou, Rogakou, Rouleau, Rulten, Smith, Soulas-Sprauel, Stevnsner, Stuart L. Rulten, Sugimura, Trucco, Wang, Yan, Yang, Yano, Yano   +59 more
core   +1 more source

CCNE1 Exerts a Protective Effect on Parkinson's Disease by Regulating Ferroptosis‐Related Proteins

Brain and Behavior, Volume 15, Issue 12, December 2025.
This study provides the first molecular insight into how CCNE1 exerts neuroprotective effects through the regulation of the ferroptosis key protein PARP16, offering a novel perspective for Parkinson's disease mechanism research. ABSTRACT Background The pathogenesis of Parkinson's disease (PD) is closely linked to ferroptosis, yet the mechanism by which
Jia Fu, Jing Zhao, Na Mi, Chao Zhang, Yali Zhang, Lifen Yao   +5 more
wiley   +1 more source

ADP-ribose hydrolases: biological functions and potential therapeutic targets

Expert Reviews in Molecular Medicine
ADP-ribosylation (ADPRylation), which encompasses poly(ADP-ribosyl)ation and mono(ADP-ribosyl)ation, is an important post-translational modification catalysed by the poly(ADP-ribose) polymerase (PARP) enzyme superfamily.
Jingpeng Wang, Zhao-Qi Wang, Wen Zong
doaj   +1 more source

CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention [PDF]

, 2020
The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear.
Kang, Sungyun, Kovalchuk, Alexander L., Kubo, Naoki, Lobanenkov, Victor V., Loukinov, Dmitri, Pugacheva, Elena M., Ren, Bing, Strunnikov, Alexander V., Tajmul, Md, Zentner, Gabriel E.   +9 more
core   +1 more source