Results 71 to 80 of about 6,764 (212)

Loss‐of‐function genetic screen unveils synergistic efficacy of PARG inhibition with combined 5‐fluorouracil and irinotecan treatment in colorectal cancer

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
LOF screening identified PARG as a modulator of CRC response to FUIRI treatment. HT29 PARG‐KO cells showed increased PAR, DNA damage, apoptosis, and 5FU sensitivity. Pharmacological PARG inhibition synergised with 5FU and SN38 in CRC cell lines. HT29 PARG‐KO tumours exhibited increased sensitivity to 5FU treatment in vivo.
Cristina Queralt, Cristina Moreta‐Moraleda, Marta Costa, Ferran Grau‐Leal, Jeannine Diesch, Carla Vendrell‐Ayats, Eva Musulén, Roni H G Wright, Cristina Bugés, José Luis Manzano, Sara Cabrero‐de las Heras, Johannes Zuber, Marcus Buschbeck, Sonia‐V Forcales, Eva Martínez‐Balibrea   +14 more
wiley   +1 more source

RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair

Cell Reports, 2018
Summary: The Fanconi anemia (FA) pathway is a pivotal genome maintenance network that orchestrates the repair of DNA interstrand crosslinks (ICLs). The tumor suppressors RUNX1 and RUNX3 were shown to regulate the FA pathway independent of their canonical
Lavina Sierra Tay, Vaidehi Krishnan, Haresh Sankar, Yu Lin Chong, Linda Shyue Huey Chuang, Tuan Zea Tan, Arun Mouli Kolinjivadi, Dennis Kappei, Yoshiaki Ito   +8 more
doaj   +1 more source

Essential role of poly(ADP-ribosyl)ation in cocaine action [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance We demonstrate that chronic cocaine, including cocaine self-administration, induces poly(ADP-ribose) polymerase-1 (PARP-1) in the nucleus accumbens (NAc). Using a combination of viral-mediated gene transfer and pharmacological tools, we show that upregulation of PARP-1 in NAc dramatically enhances behavioral responses to cocaine,
Scobie, Kimberly N., Damez-Werno, Diane, Sun, HaoSheng, Shao, NingYi, Gancarz, Amy, Panganiban, Clarisse H., Dias, Caroline, Koo, Ja Wook, Caiafa, Paola, Kaufman, Lewis, Neve, Rachael L., Dietz, David M., Shen, Li, Nestler, Eric J.   +13 more
openaire   +3 more sources

Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy

Advanced Genetics, Volume 6, Issue 4, December 2025.
This review systematically delineates the fundamental role and recent advancements in DNA damage response (DDR) within the context of cancer chemotherapy. Particular emphasis is directed toward exploring the interplay between DDR status and chemosensitivity.
Anqi Lin, Jinyue He, Aimin Jiang, Jian Zhang, Quan Cheng, Hengguo Zhang, Wenjun Mao, Peng Luo   +7 more
wiley   +1 more source

Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms

Cell Death Discovery
The functional alterations of proteins and nucleic acids mainly rely on their modifications. ADP-ribosylation is a NAD+-dependent modification of proteins and, in some cases, of nucleic acids.
Hao Wu, Anqi Lu, Jiuzhi Yuan, Yang Yu, Chongning Lv, Jincai Lu   +5 more
doaj   +1 more source

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities [PDF]

, 2013
Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity ...
Ahel, Ivan, Ahel, Marijan, Banos, Benito, Barkauskaite, Eva, Brassington, Amy, Dunstan, Mark S., Lafite, Pierre, Leys, David, Mitchison, Timothy J., Tan, Edwin S., Warwicker, Jim   +10 more
core   +2 more sources

PARP Activity Is Essential for Retinal Photoreceptor Survival in the Human Homologous RhoI255del Mouse Model for Autosomal Dominant Retinitis Pigmentosa

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Inhibition of PARP with different selective inhibitors (PARPi). Olaparib (Ola), Saruparib (Sar), INO1001 (INO), and nicotinamide (NAM) all increase photoreceptor cell death in the RhoI255del/+ mouse model for autosomal dominant retinitis pigmentosa.
Yu Zhu, Azdah Hamed A. Fallatah, Kangwei Jiao, Mathias W. Seeliger, François Paquet‐Durand   +4 more
wiley   +1 more source

The Ageing Process Affects the Antioxidant Defences and the Poly (ADPribosyl)ation Activity in Cistus Incanus L. Leaves

Antioxidants, 2019
The ageing process in living organisms is characterised by the accumulation of several deleterious changes occurring in cells and tissues. The increase of reactive oxygen species with the advancement of age is responsible for the oxidative damage to ...
Carmen Arena, Luca Vitale, Anna Rita Bianchi, Carmela Mistretta, Ermenegilda Vitale, Costantino Parisi, Giulia Guerriero, Vincenzo Magliulo, Anna De Maio   +8 more
doaj   +1 more source

Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. [PDF]

, 2019
Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription.
Ampofo, Michelle, Boyle, Cody, Currie, Michelle, Datz, Haily, Harbin, Jonathan, Ji, Yingbiao, Johnson, Sarah J., Lodhi, Niraj, MacLeod, Brett, Patel, Shri, Pechenkina, Kate, Thomas, MD, Colin, Tulin, Alexei V., Wu, Chao   +13 more
core   +1 more source

Poly(ADP-ribose) polymerases regulate cell division and development in Arabidopsis roots [PDF]

, 2017
Root organogenesis involves cell division, differentiation and expansion. The molecular mechanisms regulating root development are not fully understood. In this study, we identified poly (ADP-ribose) polymerases (PARPs) as new players in root development.
Ge, Xiaochun, Gu, Zongyin, Liu, Caifeng, Liu, Weiwei, Ma, Hong, Wang, Wenjing, Wu, Qiao, Xu, Ping   +7 more
core   +1 more source