Results 61 to 70 of about 3,561,143 (397)

PROTECTIVE EFFECT OF POLY I:C AGAINST SISOMICIN NEPHBOTOXICITY IN RABBITS [PDF]

Pediatric Research, 1980
The protective effect of Poly I:C during sisomicin nephrotoxicity in rabbits was determined by measurement of the urinary enzymes alkaline phosphatase (AF),lactic dehydrogenase (LDH) and N-a-cetyl-β-glycosaminidase(NAG). 18 rabbits were divided in 3 Groups.
ZEIS, PM, NACOPOULOU, L, GOURIOTIS, D, PIERROUTSAKOS, I, KOUKOUTSAKIS, P, POGAS, N, VLACHOS, P   +6 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

TLR3 Agonist Amplifies the Anti-Inflammatory Potency of ADSCs via IL-10-Mediated Macrophage Polarization in Acute Pancreatitis

Stem Cells International
The immunoregulatory role of mesenchymal stem cells (MSCs) in inflammation is heterogeneous and can exhibit anti-inflammatory or proinflammatory properties depending on the microenvironment. We herein observed that the activation of Toll-like receptor 3 (
Jianxing Liu, Wenjing Yan, Shanshan Chen, Yingjie Sun, Fangfang Zhang, Yue Yang, Liang Jin   +6 more
doaj   +1 more source

TLR3 activation in astrocytes attenuates the nigrostriatal pathway degeneration in rodent models of Parkinson’s disease

Frontiers in Cellular Neuroscience
Toll-like receptor 3 (TLR3) is classically known for mediating inflammatory pathways in Parkinson’s disease (PD). However, the role of TLR3 in nigrostriatal degeneration in PD remains unclear.
Jaeyeong Jeong, So-Yoon Won, Young Cheul Chung, Young Cheul Chung, Won-Ho Shin, Won-Ho Shin, Byung Kwan Jin, Eun S. Park, Eun S. Park   +8 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Incorporation of biguanide compounds into poly(GL)-b-poly(GL-co-TMC-co-CL)-b-poly(GL) monofilament surgical sutures [PDF]

, 2017
A new biodegradable coating was developed for bioabsorbable monofilament sutures. Specifically, a random copolymer having 35 wt-% and 65 wt-% of lactide and trimethylene carbonate units showed appropriate flexibility, stickiness and degradation rate, as ...
Cabral, Tània, Franco García, María Lourdes, Lorenzetti, Alice, Marquez, Yolanda, Puiggalí Bellalta, Jordi, Turón Dols, Pau, Valle Mendoza, Luis Javier del   +6 more
core   +2 more sources

Therapy of Herpetic Keratitis with a Combination of Poly I: C and Idoxuridine

Ophthalmic Research, 1976
Poly I:C-IDU treatment was given to 26 eyes with superficial, and 20 eyes with stromal herpetic keratitis. In superficial keratitis the results were not superior to those of conventional IDU treatment. The favourable results observed in stromal keratitis were attributed to penetration of poly I:C into the corneal stroma, which also can explain the ...
J.A. Oosterhuis, S.H. Sie, W.A. Nolen, J. Versteeg, I.G. Jeltes   +4 more
openaire   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Immunostimulatory activity of polysaccharide–poly(I:C) nanoparticles [PDF]

Biomaterials, 2011
Immunostimulatory properties of mushroom derived polysaccharides (PS) as stand-alone agents were tested. Next, PS were nanocomplexed with polyI:C (pIC) to yield stable nanoparticles around 200 nm in size evidenced by atomic force microscopy and dynamic light scattering analyses.
Tincer G., Yerlikaya, S., Yagci F.C., Kahraman, T., Atanur O.M., Erbatur O., Gursel I.   +6 more
openaire   +7 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source