Results 71 to 80 of about 546,465 (315)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Preparing Surface-Functionalized Polymer Films with Hierarchically Ordered Structure by a Combination of Nanoimprinting and Controlled Graft Polymerization

Surfaces
It is widely recognized that fine surface structures found in nature contribute to surface functionality, and studies on the design of functional materials based on biomimetics have been actively conducted.
Masahiko Minoda, Daichi Shimizu, Tatsuya Nohara, Jin Motoyanagi   +3 more
doaj   +1 more source

Induction of Toll-Like Receptor 3-Mediated Immunity during Gestation Inhibits Cortical Neurogenesis and Causes Behavioral Disturbances

mBio, 2010
Maternal infection during pregnancy with a wide range of RNA and DNA viruses is associated with increased risk for schizophrenia and autism in their offspring.
Joari De Miranda, Kavitha Yaddanapudi, Mady Hornig, Gabriel Villar, Robert Serge, W. Ian Lipkin   +5 more
doaj   +1 more source

The crystal structure of poly[diaqua-bis(μ ₃-5-bromobenzene-1,3-dicarboxylato-κ ³ O,O,O′)-(μ ₂-1,3-bis-(4-pyridyl)-propane-κ ² N,N′)-dizinc(II))] – 5-bromobenzene-1,3-dicarboxylic acid [2/1], C₃₇H₂₉Br₃N₂O₁₄Zn₂ [PDF]

, 2023
Xiao‐Ming Shi, Yu-Jia Fu
openalex   +1 more source

[Interferon production by various means of administering modified poly I-C].

Voprosy virusologii, 1982
Modified poly(I) . poly(C) induces appreciable amounts of interferon in Macaca rhesus monkeys not only after intravenous but also after intramuscular, endolumbar, and subconjunctival inoculations. The time course and intensity of interferon production after various routes of the induced inoculation were similar.
O G, Andzhaparidze, T A, Bektemirov, M P, Burgasova, K Ia, Ogleznev   +3 more
openaire   +1 more source

Effect of Poly I:C on Experimental Respiratory Infection in Hamsters [PDF]

Applied Microbiology, 1970
The interferon inducer double-stranded polyinosinic acid and polycytidylic acid (poly I:C) was studied in hamsters experimentally infected with parainfluenza 3 virus. Upper intranasal, deep intranasal, or intraperitoneal treatment of hamsters with poly I:C (100 μg/100- to 120-g animal) 24 hr before an upper respiratory infection significantly reduced ...
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Crystal structure of catena-poly[aqua-bis[μ ₂-6-(1H-imidazol-1-yl)nicotinato-κ² N,O]copper(II)], C₁₈H₁₄N₆O₅Cu [PDF]

, 2022
Dongfeng Hong, Mengfei Li, Tian-Tian Chu
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy. [PDF]

Natl Sci Rev, 2021
Dai J, Wu M, Wang Q, Ding S, Dong X, Xue L, Zhu Q, Zhou J, Xia F, Wang S, Hong Y.   +10 more
europepmc   +1 more source