Results 81 to 90 of about 3,561,143 (397)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs

Respiratory Research
Background Microbial infections, particularly those caused by rhinovirus (RV) and respiratory syncytial virus (RSV), are major triggers for asthma exacerbations. These viruses activate toll-like receptors (TLRs), initiating an innate immune response.
Yujiao Xiang, Jielu Liu, Mu Nie, Gunnar Nilsson, Jesper Säfholm, Mikael Adner   +5 more
doaj   +1 more source

DNA double helices for single molecule electronics [PDF]

, 2007
The combination of self-assembly and electronic properties as well as its true nanoscale dimensions make DNA a promising candidate for a building block of single molecule electronics.
A. V. Malyshev, C. Branden, D. Porath, D. K. Ferry   +3 more
core   +2 more sources

[Interferon induction in monkeys by poly I-C complex with poly-L-lysine].

Voprosy virusologii, 1977
The spectrum characteristics, the stability to pancreatic RN-ase and hydrolases of the monkey and mouse blood as well as interferon induction in mice and monkeys by poly I: poly C and its complex with poly-l-lysine were studied. The complex was found to be more stable to the treatments tested as well as markedly interferonogenically active in Macaca ...
T A, Bektemirov, M P, Burgasova, O G, Andzhaparidze   +2 more
openaire   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The influence of CD40 ligation and interferon-γ on functional properties of human monocyte-derived dendritic cells activated with polyinosinic-polycytidylic acid [PDF]

Vojnosanitetski Pregled, 2011
Background/Aim. Ligation of a Toll-like receptor (TLR) by specific TLR agonists is a powerful tool for maturation induction of monocyte-derived dendritic cells (MoDCs).
Dragičević Ana, Džopalić Tanja, Vasilijić Saša, Vučević Dragana, Božić Biljana, Majstorović Ivana, Balint Bela, Čolić Miodrag   +7 more
doaj   +1 more source

Poly I∶C and R848 Induce Cell Proliferation in the Intact Rat Spinal Cord [PDF]

, 2008
目的研究Poly I∶C与R848对脊髓细胞增殖的诱导效应。方法大鼠单次腹腔注射(ip)Poly I∶C与R848,增殖的细胞由BrdU跟踪标记。结果Poly I∶C与R848可引起大鼠脊髓BrdU+细胞明显增加,于注射后2~3 d达最高,随后快速降至正常水平,同时可见BrdU+/Nestin+细胞存在,并伴小胶质细胞的活化,未见有ED-1+/BrdU+的细胞。地塞米松可抑制细胞增殖及小胶质细胞活化,而消炎痛无此作用。结论配体被TLR识别后可能参与脊髓内正常神经细胞的发生过程 ...
吕姝焱, 徐顺清, 苏艳华
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Learning Coverage Functions and Private Release of Marginals [PDF]

, 2014
We study the problem of approximating and learning coverage functions. A function $c: 2^{[n]} \rightarrow \mathbf{R}^{+}$ is a coverage function, if there exists a universe $U$ with non-negative weights $w(u)$ for each $u \in U$ and subsets $A_1, A_2 ...
Feldman, Vitaly, Kothari, Pravesh
core   +1 more source

Structure and RNA binding of the third KH domain of poly(C)-binding protein 1

Nucleic Acids Research, 2005
Poly(C)-binding proteins (CPs) are important regulators of mRNA stability and translational regulation. They recognize C-rich RNA through their triple KH (hn RNP K homology) domain structures and are thought to carry out their function though direct ...
M. Sidiqi, J. Wilce, J. Vivian, C. Porter, A. Barker, P. Leedman, M. Wilce   +6 more
semanticscholar   +1 more source