Results 1 to 10 of about 44,780 (134)

Opposing Roles for ATP13A2 and ATP13A3 in Breast Cancer Subtype-Specific Polyamine Homeostasis [PDF]

Biomolecules
Polyamine homeostasis is essential for normal cellular function and is maintained through coordinated regulation of polyamine biosynthesis, catabolism, and transport.
Emily Meeus, Jan Eggermont, Sarah van Veen, Peter Vangheluwe   +3 more
doaj   +2 more sources

Polyamine metabolism as a regulator of cellular and organismal aging [PDF]

Amino Acids
Polyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura, Jun Takayama, Akihiro Oguro, Yusuke Terui   +3 more
doaj   +2 more sources

Combined inhibition of polyamine biosynthesis and uptake blocks Candida albicans virulence [PDF]

mBio
Polyamines, small organic polycations, are essential for life, and cells maintain polyamines via synthesis and uptake. Recently, we identified Hol1 as the high-affinity polyamine transporter in Saccharomyces cerevisiae.
Arya Vindu, Brendan D. Snarr, Chune Cao, Ronda J. Rolfes, Otto Phanstiel, Michail S. Lionakis, Thomas E. Dever   +6 more
doaj   +2 more sources

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy

Medical Sciences, 2022
Polyamines are small polycationic alkylamines involved in many fundamental cellular processes, including cell proliferation, survival, and protection from oxidative stress.
Cassandra E. Holbert, Jackson R. Foley, Ao Yu, Tracy Murray Stewart, Otto Phanstiel, David Oupicky, Robert A. Casero   +6 more
doaj   +1 more source

ATP13A4 Upregulation Drives the Elevated Polyamine Transport System in the Breast Cancer Cell Line MCF7

Biomolecules, 2023
Polyamine homeostasis is disturbed in several human diseases, including cancer, which is hallmarked by increased intracellular polyamine levels and an upregulated polyamine transport system (PTS).
Sarah van Veen, Antria Kourti, Elke Ausloos, Joris Van Asselberghs, Chris Van den Haute, Veerle Baekelandt, Jan Eggermont, Peter Vangheluwe   +7 more
doaj   +1 more source

Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

Biosensors, 2022
The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein ...
Bingli Lu, Lingyun Wang, Xueguang Ran, Hao Tang, Derong Cao   +4 more
doaj   +1 more source

ATP13A3 facilitates polyamine transport in human pancreatic cancer cells

Scientific Reports, 2022
The purpose of this study is to provide an increased understanding of the molecular mechanisms responsible for mammalian polyamine transport, a process that has been a long-standing ‘black box’ for the polyamine field.
Vandana Sekhar, Thomas Andl, Otto Phanstiel   +2 more
doaj   +1 more source

Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity

Cells, 2022
Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent work has highlighted that polyamines exert profound roles on the mammalian immune system, particularly inflammation and cancer. The mechanisms by which they control
Tzu-yi Chia, Andrew Zolp, Jason Miska
doaj   +1 more source

Upregulation of Polyamine Transport in Human Colorectal Cancer Cells

Biomolecules, 2020
Polyamines are essential growth factors that have a positive role in cancer cell growth. Their metabolic pathway and the diverse enzymes involved have been studied in depth in multiple organisms and cells.
Misael Corral, Heather M. Wallace
doaj   +1 more source

Polyamine Analog Diethylnorspermidine Restricts Coxsackievirus B3 and Is Overcome by 2A Protease Mutation In Vitro

Viruses, 2021
Enteroviruses, including Coxsackievirus B3 (CVB3), are pervasive pathogens that cause significant disease, including cardiomyopathies. Unfortunately, no treatments or vaccines are available for infected individuals.
Bridget M. Hulsebosch, Bryan C. Mounce
doaj   +1 more source