Results 11 to 20 of about 106,104 (288)

Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis. [PDF]

PLoS ONE, 2013
Polyamines (spermine and spermidine) play many important roles in cellular function and are supplied from the intestinal lumen. We have shown that continuous high polyamine intake inhibits age-associated pathologies in mice.
Kuniyasu Soda, Yoshihiko Kano, Fumihiro Chiba, Kei Koizumi, Yuichiro Miyaki   +4 more
doaj   +1 more source

The Impact of Polyamine Precursors, Polyamines, and Steroid Hormones on Temporal Messenger RNA Abundance in Bovine Satellite Cells Induced to Differentiate

Animals, 2021
Emerging research suggests that hormones found in anabolic implants interact with polyamine biosynthesis. The objective of this study was to determine the effects of steroidal hormones, polyamines and polyamine precursors on bovine satellite cell (BSC ...
Caleb C. Reichhardt, Lillian L. Okamoto, Laura A. Motsinger, Brian P. Griffin, Gordon K. Murdoch, Kara J. Thornton   +5 more
doaj   +1 more source

Polyamine–Drug Conjugates: Do They Boost Drug Activity?

Molecules, 2023
Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacological ...
Filippo Basagni, Giambattista Marotta, Michela Rosini, Anna Minarini   +3 more
doaj   +1 more source

Positive Correlation between Relative Concentration of Spermine to Spermidine in Whole Blood and Skeletal Muscle Mass Index: A Possible Indicator of Sarcopenia and Prognosis of Hemodialysis Patients

Biomedicines, 2023
Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients with renal ...
Hidenori Sanayama, Kiyonori Ito, Susumu Ookawara, Takeshi Uemura, Sojiro Imai, Satoshi Kiryu, Miho Iguchi, Yoshio Sakiyama, Hitoshi Sugawara, Yoshiyuki Morishita, Kaoru Tabei, Kazuei Igarashi, Kuniyasu Soda   +12 more
doaj   +1 more source

Novel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System

Biomolecules, 2023
Cells acquire polyamines putrescine (PUT), spermidine (SPD) and spermine (SPM) via the complementary actions of polyamine uptake and synthesis pathways.
Marine Houdou, Nathalie Jacobs, Jonathan Coene, Mujahid Azfar, Roeland Vanhoutte, Chris Van den Haute, Jan Eggermont, Veronique Daniëls, Steven H. L. Verhelst, Peter Vangheluwe   +9 more
doaj   +1 more source

Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells [PDF]

, 2015
Acknowledgments We thank NHS Grampian for financial support of this work.Peer reviewedPublisher ...
Cameron, Gary A., Li, Jun, Wallace, Heather M.   +2 more
core   +1 more source

Biophysical and biological contributions of polyamine-coated carbon nanotubes and bidimensional buckypapers in the delivery of miRNAs to human cells [PDF]

, 2017
Recent findings in nanomedicine have revealed that carbon nanotubes (CNTs) can be used as potential drug carriers, therapeutic agents and diagnostics tools.
Bordi, Federico, Casciardi, Stefano, Celluzzi, Antonella, D’Oria, Valentina, Masotti, Andrea, Materazzi, Stefano, Paolini, Alessandro, Pezzullo, Marco, Risoluti, Roberta, Sennato, Simona   +9 more
core   +2 more sources

Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]

, 2013
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer, Batey, Besteiro, Birkholtz, Breaker, Carter, Clayton, Coustou, De Gaudenzi, Ebikeme, Fairlamb, Hendriks, Jacob, Jensen, Kabani, Lamour, Mangold, Martinez-Calvillo, Nguyen, Perez-Leal, Persson, Phillips, Stuart, Veitch, Vincent, Ward, Willert, Willert, Willert, Wirtz, Wurst, Wurst, Xiao, Xiao, Zhang   +34 more
core   +1 more source

Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers

Medical Sciences, 2017
Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC).
Chelsea Massaro, Jenna Thomas, Otto Phanstiel   +2 more
doaj   +1 more source

Translational recoding as a feedback controller : systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift [PDF]

, 2011
Peer reviewedPublisher ...
Amarantos, Amarantos, Balasundaram, Balasundaram, Bonetti, Chattopadhyay, Claudia Rato, Cohn, Cohn, Cornish-Bowden, Declan G. Bates, Delbecq, Fontaniella, Forbes, Gietz, Goldstein, Heather M. Wallace, Howard, Hryniewicz, Ian Stansfield, Ivanov, Joets, Johnston, Kim, Li, Liu, Matsufuji, Murakami, Palanimurugan, Petros, Poulin, Rodriguez-Caso, Sambrook, Sherman, Stahl, Sundararajan, Svetlana R. Amirova, Tabor, Tobias, Vimaladithan, Wallace, Wallace, White, Whitney, Williams, Xaplanteri, Yoshida   +46 more
core   +2 more sources