Results 21 to 30 of about 106,104 (288)

Investigation of The Roles of Hydrogen Peroxide and NADPH Oxidase in The Regulation of Polyamine Metabolism in Maize Plants under Drought Stress Conditions

Journal of Agricultural Sciences, 2022
The relationship between hydrogen peroxide and the metabolism of polyamines and the role of NADPH oxidase (NOX) in that relationship under drought conditions remains unclear.
Aykut Sağlam, Mehmet Demiralay, Fuat Yetişsin, Asım Kadıoğlu   +3 more
doaj   +1 more source

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Frontiers in Immunology, 2022
The study of metabolism provides important information for understanding the biological basis of cancer cells and the defects of cancer treatment. Disorders of polyamine metabolism is a common metabolic change in cancer.
Jiachun Lian, Jiachun Lian, Yanfang Liang, Hailiang Zhang, Hailiang Zhang, Minsheng Lan, Ziyu Ye, Ziyu Ye, Ziyu Ye, Bihua Lin, Bihua Lin, Bihua Lin, Xianxiu Qiu, Xianxiu Qiu, Xianxiu Qiu, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng, Jincheng Zeng   +18 more
doaj   +1 more source

Brevibacterium sandarakinum sp. nov., isolated from a wall of an indoor environment [PDF]

, 2009
A Gram-stain-positive, rod-shaped, non-endospore-forming, orange-pigmented (coloured) actinobacterium (01-Je-003T) was isolated from the wall of an indoor environment primarily colonized with moulds.
Busse, Hans-Jürgen, Kämpfer, Peter, Lodders, Nadine, Schäfer, Jenny   +3 more
core   +1 more source

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial [PDF]

, 2019
Background: Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues.
Benson, Gloria, Buchert, Ralph, Flöel, Agnes, Grittner, Ulrike, Hetzer, Stefan, Horn, Nora, Kopp, Ute, Köbe, Theresa, Lange, Catharina, Madeo, Frank, Maglione, Marta, Mai, Knut, Michael, Eva, Märschenz, Stefanie, Schmitz, Dietmar, Schwarz, Claudia, Sigrist, Stephan J., Stekovic, Slaven, Wirth, Miranka   +18 more
core   +2 more sources

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

Frontiers in Oncology, 2012
Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that upregulation of polyamine pro-synthetic enzymes and downregulation of ...
Laura Dawn Gamble, Michael D Hogarty, Xuenyuan eLiu, David S Ziegler, David S Ziegler, Glenn M Marshall, Glenn M Marshall, Murray D Norris, Michelle eHaber   +8 more
doaj   +1 more source

Catalytic and mechanistic studies into the epoxidation of styrenes using manganese complexes of structurally similar polyamine ligands [PDF]

, 2014
The synthesis and catalytic activity of manganese(ii) complexes of two polyamine ligands is reported which highlights how a small structural change in the ligand affects the overall catalytic behaviour.
Al-Safadi, R, De Faveri, G, Follier, T, Ilyashenko, G, Motevalli, M, Watkinson, M   +5 more
core   +1 more source

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source

Antitumor potential of polyamines in cancer

Acta Biochimica et Biophysica Sinica
The dysregulation of polyamines in tumors has made polyamine metabolism an appealing target for cancer therapy. Gene mutations drive the reprogramming of polyamine metabolism in tumors, presenting promising opportunities for clinical treatment.
Liu He, Liu Yi, Wang Xinyue, Xiao Zhiwen, Ni Quanxing, Yu Xianjun, Luo Guopei   +6 more
doaj   +1 more source

Understanding the Effects of Trenbolone Acetate, Polyamine Precursors, and Polyamines on Proliferation, Protein Synthesis Rates, and the Abundance of Genes Involved in Myoblast Growth, Polyamine Biosynthesis, and Protein Synthesis in Murine Myoblasts

Biology, 2023
Research suggests that androgens increase skeletal muscle growth by modulating polyamine biosynthesis. As such, the objective of this study was to investigate effects of anabolic hormones, polyamine precursors, and polyamines relative to proliferation ...
Laura A. Motsinger, Lillian L. Okamoto, Nikole E. Ineck, Brynne A. Udy, Christopher L. Erickson, Youssef Harraq, Caleb C. Reichhardt, Gordon K. Murdoch, Kara Jean Thornton   +8 more
doaj   +1 more source