Results 21 to 30 of about 44,780 (134)

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

Frontiers in Oncology, 2012
Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that upregulation of polyamine pro-synthetic enzymes and downregulation of ...
Laura Dawn Gamble, Michael D Hogarty, Xuenyuan eLiu, David S Ziegler, David S Ziegler, Glenn M Marshall, Glenn M Marshall, Murray D Norris, Michelle eHaber   +8 more
doaj   +1 more source

Antitumor potential of polyamines in cancer

Acta Biochimica et Biophysica Sinica
The dysregulation of polyamines in tumors has made polyamine metabolism an appealing target for cancer therapy. Gene mutations drive the reprogramming of polyamine metabolism in tumors, presenting promising opportunities for clinical treatment.
Liu He, Liu Yi, Wang Xinyue, Xiao Zhiwen, Ni Quanxing, Yu Xianjun, Luo Guopei   +6 more
doaj   +1 more source

Understanding the Effects of Trenbolone Acetate, Polyamine Precursors, and Polyamines on Proliferation, Protein Synthesis Rates, and the Abundance of Genes Involved in Myoblast Growth, Polyamine Biosynthesis, and Protein Synthesis in Murine Myoblasts

Biology, 2023
Research suggests that androgens increase skeletal muscle growth by modulating polyamine biosynthesis. As such, the objective of this study was to investigate effects of anabolic hormones, polyamine precursors, and polyamines relative to proliferation ...
Laura A. Motsinger, Lillian L. Okamoto, Nikole E. Ineck, Brynne A. Udy, Christopher L. Erickson, Youssef Harraq, Caleb C. Reichhardt, Gordon K. Murdoch, Kara Jean Thornton   +8 more
doaj   +1 more source

The mechanisms by which polyamines accelerate tumor spread

Journal of Experimental & Clinical Cancer Research, 2011
Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for polyamine synthesis. In addition to their de novo
Soda Kuniyasu
doaj   +1 more source

Antizyme Inhibitors in Polyamine Metabolism and Beyond: Physiopathological Implications

Medical Sciences, 2018
The intracellular levels of polyamines, cationic molecules involved in a myriad of cellular functions ranging from cellular growth, differentiation and apoptosis, is precisely regulated by antizymes and antizyme inhibitors via the modulation of the ...
Bruno Ramos-Molina, Ana Lambertos, Rafael Peñafiel   +2 more
doaj   +1 more source

Mycolicibacterium smegmatis possesses operational agmatinase but contains no detectable polyamines

International Journal of Mycobacteriology, 2020
Background: Polyamines are widespread intracellular molecules able to influence antibiotic susceptibility, but almost nothing is known on their occurrence and physiological role in mycobacteria.
Mikhail Zamakhaev, Ivan Tsyganov, Larisa Nesterova, Anna Akhova, Artem Grigorov, Julia Bespyatykh, Tatyana Azhikina, Alexander Tkachenko, Mikhail Shumkov   +8 more
doaj   +1 more source

Helical polyamines

Chemical Science
The first report on isotactic poly(propylene imine) and its stereoblock copolymers prepared by living anionic polymerization.
Daniël Hagedoorn, Sandra Michel-Souzy, Bartłomiej Gostyński, Hubert Gojzewski, Piotr Paneth, Jeroen J. L. M. Cornelissen, Frederik R. Wurm   +6 more
openaire   +3 more sources

A Cyclodextrin Hydrogel For Polyamine Capturing In Periodontitis Treatment

International Dental Journal
Aim or purpose: Polyamine accumulation exacerbates inflammation and tissue destruction in periodontitis, but its therapeutic potential remains unclear, and this study evaluates a polyamine-scavenging hydrogel for periodontitis inflammation by restoring ...
Simeng Wang, Jianhua Li, Weiwei Zhao
doaj   +1 more source

Genetically encoded fluorescent reporter for polyamines

Nature Communications
Polyamines are abundant and evolutionarily conserved metabolites that are essential for life. Dietary polyamine supplementation extends life-span and health-span. Dysregulation of polyamine homeostasis is linked to Parkinson’s disease and cancer, driving
Pushkal Sharma, Colin Y. Kim, Heather R. Keys, Shinya Imada, Alex B. Joseph, Luke Ferro, Tenzin Kunchok, Rachel Anderson, Yulin Sun, Ömer H. Yilmaz, Jing-Ke Weng, Ankur Jain   +11 more
doaj   +1 more source

Polyamines: total daily intake in adolescents compared to the intake estimated from the Swedish Nutrition Recommendations Objectified (SNO)

Food & Nutrition Research, 2011
Background: Dietary polyamines have been shown to give a significant contribution to the body pool of polyamines. Knowing the levels of polyamines (putrescine, spermidine, and spermine) in different foods and the contribution of daily food choice to ...
Mohamed Atiya Ali, Eric Poortvliet, Roger Strömberg, Agneta Yngve   +3 more
doaj   +1 more source