Results 61 to 70 of about 9,343 (180)

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

Plant Polyamines

Plants, 2020
Polyamines are small organic compounds found in all living organisms. According to the high degree of positive charge at physiological pH, they interact with negatively charged macromolecules, such as DNA, RNA, and proteins, and modulate their activities.
Taku Takahashi
doaj   +1 more source

Advances in the Development of Lipid Nanoparticles for mRNA Delivery

Small Structures, Volume 7, Issue 2, February 2026.
This review provides an integrated overview of mRNA–lipid nanoparticle (LNP) design, including lipid composition, scalable manufacturing, and structure–activity relationships. We highlight strategies for targeted delivery, physicochemical tuning, and high‐throughput screening such as DNA barcoding.
Xing Wang, Letao Xu, Zhenwei Lan, Yue Hui, Yun Liu, Guangze Yang, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Bis(benzyl)polyamine analogs as novel substrates for polyamine oxidase.

Journal of Biological Chemistry, 1990
N,N'-Bis(benzyl)polyamine analogs were found to be substrates for highly purified polyamine oxidase. Metabolism of these analogs was apparently dependent on molecular O2 and resulted in the formation of benzaldehyde, H2O2, and a polyamine analog with free terminal amines.
A J, Bitonti, J A, Dumont, T L, Bush, D M, Stemerick, M L, Edwards, P P, McCann   +5 more
openaire   +2 more sources

The Factors Involved in Plant–Insect–Microbe Interactions Expanded: Genome Analysis and Description of Frigoribacterium adelgis sp. nov.

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Aerobic Actinobacteria belonging to the genus Frigoribacterium were isolated from adelgid Adelges (Aphrastasia) pectinatae collected from a Korean fir tree. Genomic analysis showed that these bacteria encode a range of factors that may be involved in the interactions between Frigoribacterium strains, adelgids and/or Korean fir trees.
Gustė Tamošiūnaitė, Jekaterina Havelka, Raimonda Baranauskienė, Justas Lazutka, Nomeda Kuisiene   +4 more
wiley   +1 more source

Application of sucrose modulates the expressions of genes involved in proline and polyamine metabolism in maize seedlings exposed to drought

Biologia Plantarum, 2019
Sucrose, proline, and polyamines are compatible solutes accumulating in plant tissues and increasing cellular osmolarity under environmental stresses. These compatible solutes and hydrogen peroxide can function as signaling molecules in plants. There has
C. Altuntaş, A. Sezgin, M. Demiralay, R. Terzi, A. Sağlam, A. Kadioğlu   +5 more
doaj   +1 more source

Spatial and temporal dynamics of peroxidase and amine oxidase activity is linked to polyamines and lignin in wheat grains

Biologia Plantarum, 2010
The regulation of contents and activities of peroxidase (POX), diamine oxidase (DAO) and polyamine oxidase (PAO) were determined in relation to polyamines and lignin content in wheat (Triticum aestivum L.) grains.
B. Asthir, S. Kaur, W. Spoor, T. Roitsch
doaj   +1 more source

Polyamine pathway in neurological disorders: Potential therapeutic implications based on current evidences

Brain Research Bulletin
Polyamines (PAs) with a positive charge and low molecular weight, are a class of general biogenic amines that are involved in many important cellular processes, including maintaining nucleic acid stability, controlling ion channel activity, regulating ...
Mengqi Yan, Yingying Tang, Shuo Zhang, Li Yu, Cenglin Xu   +4 more
doaj   +1 more source

The effect of exogenous spermidine concentration on polyamine metabolism and salt tolerance in zoysiagrass (Zoysia japonica Steud) subjected to short-term salinity stress

Frontiers in Plant Science, 2016
Salt stress, and particularly short-term salinity stress, is one of the most serious abiotic factors limiting plant survival and growth in China. It has been established that exogenous spermidine (Spd) stimulats tolerance to salt stress in plants. In the
Shucheng Li, Han Jin, Qiang Zhang
doaj   +1 more source