Results 61 to 70 of about 29,329 (143)

Plant‐Derived Monomers for Grey Hair Reversal Through Upregulation of Melanogenesis and Tyrosinase Activity

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Grey hair, a common ageing‐associated phenomenon in humans, is mainly attributed to the damage of melanocytes and the absence of melanin. Grey hair has long been treated with traditional medicine, and new research has shown that various plant‐derived monomers can increase tyrosinase activity and melanogenesis, indicating that they may have ...
Chengjie Wei, Xiaomin Hou, Xuelu Jiang, Ming Gao, Yan Gao, Lin Bi, Jisheng Nie, Liangyuan Zhao, Yiwei Shi, Xiaojiang Qin   +9 more
wiley   +1 more source

Natural History of Idiosyncratic Drug‐Induced Liver Injury and Prognostic Models

Liver International, Volume 45, Issue 6, June 2025.
ABSTRACT Background and Aims: Drug‐induced liver injury (DILI) remains a leading cause of acute liver failure worldwide. Drugs such as isoniazid, alone or in combination with other anti‐tuberculosis drugs, as well as a growing number of herbal and complementary medicines, have been implicated in most cases of acute liver failure in registry studies ...
Harshad C. Devarbhavi, Raúl J. Andrade
wiley   +1 more source

2,2-Diphenyl-1-picrylhydrazyl radical-scavenging active components from Polygonum multiflorum Thunb.

, 1999
An activity-directed fractionation and purification process was used to identify the antioxidative components of Polygonum multiflorum Thunb. (PM). Dried root of PM was extracted with 95% ethanol and then separated into water, ethyl acetate, and hexane ...
Ho, CT, Rosen, RT, Wang, M, Chen, Y
core   +1 more source

Processing‐induced reduction in dianthrones content and toxicity of Polygonum multiflorum: Insights from ultra‐high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 685-695, April 2025.
In this study, we conducted measurements to determine the content of dianthrones in Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) samples from different stages of processing. Furthermore, we evaluated their hepatotoxicity using the human hepatocyte cell line L02 and Zebrafish embryos.
Wan‐Fang Li, Ying Wang, Cai‐Xia Qiu, Jie Li, Jie Bao, Jian‐Bo Yang, Hong‐Tao Jin   +6 more
wiley   +1 more source

Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to Polygonum multiflorum: A Cross-Sectional Cohort Study

Frontiers in Medicine, 2020
Aim: The diagnosis of drug-induced liver injury (DILI) remains a challenge and the cases of Polygonum multiflorum Thunb. (PM) induced DILI (PM-DILI) have received much attention This study aimed to identify a simple and high-efficiency approach to PM ...
Ying Huang, Ying Huang, Xu Zhao, Zi-teng Zhang, Shuai-shuai Chen, Shan-shan Li, Zhuo Shi, Jing Jing, Ang Huang, Yu-ming Guo, Zhao-fang Bai, Zheng-sheng Zou, Xiao-he Xiao, Jia-bo Wang, Ming Niu, Ming Niu   +15 more
doaj   +1 more source

Emodin Suppresses Fluoride‐Induced Pyroptosis in SH‐SY5Y Cells Through the Inhibition of NLRP3 Inflammasome Activation

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Our preliminary investigation has unveiled that emodin may inhibit the neurotoxic effects of sodium fluoride (NaF) on SH‐SY5Y cells by deactivating ERK and activating the Nrf2/HO‐1 signaling pathway. This action thereby restores synaptic damage and reduces excessive reactive oxygen species (ROS) generation.
Chencen Lai, Taibai Jiang, Tingting Xu, Taiwei Zhang, Yiyuan Zhou, Dongyang Deng, Qian Chen, Erick Gutiérrez-Grijalva   +7 more
wiley   +1 more source

An optimized short‐term steroid therapy for chronic drug‐induced liver injury: A prospective randomized clinical trial

Liver International, Volume 44, Issue 6, Page 1435-1447, June 2024.
Abstract Background and Aims The use of corticosteroids in chronic drug‐induced liver injury (DILI) is an important issue. Our previous randomized controlled trial showed that patients with chronic DILI benefited from a 48‐week steroid stepwise reduction (SSR) regimen.
Ang Huang, Yun Zhu, Shuhong Liu, Ying Sun, Zherui Liu, Qing‐sheng Liang, Jun Zhao, Bin‐xia Chang, Jing‐feng Bi, Jiang‐tao Liu, Xing‐ran Zhai, Huan Xie, Ning Li, Hui Tian, Lin Han, Yingjie Zhuang, Hongbin Ma, Guang‐ju Teng, Wei Zhang, Guruprasad P. Aithal, Dong Ji, Jingmin Zhao, Zhengsheng Zou   +22 more
wiley   +1 more source

Rapid Quality Assessment of Polygoni Multiflori Radix Based on Near‐Infrared Spectroscopy

Journal of Spectroscopy, Volume 2024, Issue 1, 2024.
The precise and prompt determination of quality control indicators such as moisture, stilbene glycosides, and anthraquinone glycosides is crucial in assessing the quality of Polygoni Multiflori Radix. Near‐infrared spectroscopy is a nondestructive analytical technique that offers a more desirable approach than traditional methods for assessing content ...
Bin Jia, Ziying Mai, Chaoqun Xiang, Qiwen Chen, Min Cheng, Longkai Zhang, Xue Xiao, Michele Fedel   +7 more
wiley   +1 more source

TSG Extends the Longevity of Caenorhabditis elegans by Targeting the DAF-16/SKN-1/SIR-2.1-Mediated Mitochondrial Quality Control Process

Antioxidants
The improvement of mitochondrial function is described as a strategy for alleviating oxidative stress and intervening in the aging process. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) is one of the major bioactive components isolated from ...
Menglu Sun, Congmin Wei, Yehui Gao, Xinyan Chen, Kaixin Zhong, Yingzi Li, Zhou Yang, Yihuai Gao, Hongbing Wang   +8 more
doaj   +1 more source

Predictive Assessment of the Antiviral Properties of Imperata cylindrica against SARS‐CoV‐2

Advances in Virology, Volume 2024, Issue 1, 2024.
The omicron variant and its sublineages are highly contagious, and they still constitute a global source of concern despite vaccinations. Hospitalizations and mortality rates resulting from infections by these variants of concern are still common.
Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu, Carla Zannella   +2 more
wiley   +1 more source