Results 51 to 60 of about 29,329 (143)

Sustainable valorization of functional phytochemicals from Polygonum multiflorum using natural deep eutectic solvents (NADES)

Industrial Crops and Products
This study applied a natural deep eutectic solvent (NADES) consisting of malic acid and choline chloride for bioactive compound extraction from Reynoutria multiflora (Thunb.) Moldenke (syn.
Kyeong-Ok Choi, Yeongjun Ban, Youngmin Kang   +2 more
doaj   +1 more source

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges

Frontiers in Pharmacology, 2019
Polygonum multiflorum Thunb. (PM), called Heshouwu in China, is a popular Chinese medicine in clinical practice. Several clinical studies have been conducted to evaluate the traditional therapeutic claims and to study the potential therapeutic activity ...
Yi Liu, Wenping Wang, Mingyi Sun, Baorui Ma, Linnuo Pang, Yuanyuan Du, Xiaoxv Dong, Xingbin Yin, Jian Ni   +8 more
doaj   +1 more source

Lipidomics Analysis Indicates Disturbed Hepatocellular Lipid Metabolism in Reynoutria multiflora-Induced Idiosyncratic Liver Injury

Frontiers in Pharmacology, 2020
The root of Reynoutria multiflora (Thunb.) Moldenke (syn.: Polygonum multiflorum Thunb., HSW) is a distinguished herb that has been popularly used in traditional Chinese medicine (TCM).
Xiaofang Wu, Yating Zhang, Jiaqi Qiu, Ya Xu, Jing Zhang, Jing Zhang, Juan Huang, Junqi Bai, Zhihai Huang, Zhihai Huang, Xiaohui Qiu, Xiaohui Qiu, Xiaohui Qiu, Xiaohui Qiu, Wen Xu, Wen Xu   +15 more
doaj   +1 more source

Generalizability of Enzyme‐Based Isolation Approach for Extracellular Vesicles From Traditional Medicinal Plants

Journal of Extracellular Biology, Volume 4, Issue 10, October 2025.
ABSTRACT Extracellular vesicles (EVs) from plants, particularly traditional medicinal plants, have garnered therapeutic interest. However, therapeutic utility requires establishing effective extraction and purification protocols for manufacturing. Here, we systemically optimized an enzyme‐based EV extraction method and demonstrated the generalizability
Qian Wang, Renwei Jing, Nan Cao, Xingjie He, Zhongqiu Yang, Leijie Zhang, Yi Liu, Ruibing Chen, Beibei Xiang, Xiaodong Xie, HaiFang Yin   +10 more
wiley   +1 more source

Elucidating the Mechanism of Emodin in Treating Post‐Stroke Depression Through Network Pharmacology and Animal Experiments

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
Em could alleviate the neurological impairment and depression behavior of PSD. Network pharmacology and molecular docking were used to explore the multiple mechanisms of Em therapy for PSD. The mechanism of Em in treating PSD may be achieved by regulating the proBDNF/mBDNF balance through tPA and Furin, improving cell apoptosis.
Xiaoju Liu, Jie Gao, Kai Yang, Weiming Zhu, Ming Su, Zichun Liu, Yaxin Yuan, Linya Cao, Tong Wu, Wei Liu   +9 more
wiley   +1 more source

Quality Assessment of Polygonum cuspidatum and Polygonum multiflorum by 1H NMR Metabolite Fingerprinting and Profiling Analysis.

, 2010
peer reviewedThe quality assessment and control of traditional Chinese medicines (TCM) nowadays receives a great deal of attention worldwide and particularly in Europe with its increasing local use. POLYGONUM CUSPIDATUM Siebold & Zucc.
Pascal de Tullio, Jason, Charlotte, De Tullio, Pascal, Jean-Noël Wauters, Van der Heyden, Yvan, Monique Tits, Wauters, Jean-Noël, Angenot, Luc, Charlotte Jason, Frederich, Michel, Fan, Guorong, Michel Frédérich, Yvan Van der Heyden, Luc Angenot, Tits, Monique, Guorong Fan   +15 more
core   +1 more source

Activation of Adenosine A₁ Receptor in Ischemic Stroke: Neuroprotection by Tetrahydroxy Stilbene Glycoside as an Agonist

Antioxidants, 2021
Ischemic stroke is the main cause of death/disability, posing a great menace to human health. Though efforts to search for therapeutic drugs are ongoing, few of them have succeeded. Adenosine A1 receptor (A1R) activation could ameliorate ischemic injury,
Lingyu Ruan, Guanghui Li, Wenlong Zhao, Huihui Meng, Qi Zheng, Junsong Wang   +5 more
doaj   +1 more source

An Up‐to‐Date Review of Traditional Chinese Medicine in the Treatment of Atherosclerosis: Components, Mechanisms, and Therapeutic Potentials

Phytotherapy Research, Volume 39, Issue 8, Page 3709-3735, August 2025.
Traditional Chinese medicine in atherosclerosis: multi‐target modulation of pathogenesis. ABSTRACT Atherosclerosis is a chronic inflammatory disease and a major global health concern. In recent years, traditional Chinese medicines (TCMs) have demonstrated multi‐target therapeutic potential against atherosclerosis by modulating inflammatory responses ...
Dilaram Nijat, Qingzhe Zhao, Gulhasal Abdurixit, Jianhua He, Haipeng Liu, Jinyao Li   +5 more
wiley   +1 more source

Multi-functional investigation via biological and computational insight into extracts and components from root of Polygonum multiflorum

Industrial Crops and Products
The roots of Polygonum multiflorum Thunb [Reynoutria multiflora (Thunb.) Moldenke], commonly known as He Shou Wu, have been historically utilized in traditional Chinese medicine, primarily for their anti-aging efficacy.
Chia-Hsuan Tsai, Yu-Jyun Guo, Sin-Min Li, Hsuan-Yu Chou, Jih-Jung Chen   +4 more
doaj   +1 more source

High-Throughput Identification of Organic Compounds from Polygoni Multiflori Radix Praeparata (Zhiheshouwu) by UHPLC-Q-Exactive Orbitrap-MS

Molecules, 2021
Polygoni Multiflori Radix Praeparata (PMRP), as the processed product of tuberous roots of Polygonum multiflorum Thunb., is one of the most famous traditional Chinese medicines, with a long history.
Shaoyun Wang, Xiaozhu Sun, Shuo An, Fang Sang, Yunli Zhao, Zhiguo Yu   +5 more
doaj   +1 more source