Results 31 to 40 of about 4,367 (175)

Efficacy of Polyhexamethylene Biguanide in Reducing Post-Operative Infections: A Systematic Review and Meta-Analysis

, 2023
Background: Post-operative infections are a substantial cause of morbidity and mortality worldwide. Polyhexamethylene biguanide (PHMB) is an antimicrobial agent that has been used in various surgical settings to prevent infections.
Giuseppe Caravella, Castiello, Gianluca, Andronache, Andreea Alina, Arianna Magon, Antonio Saracino, Gianluca Conte, Conte, Gianluca, Tiziana Fiorini, Rosario Caruso, Fiorini, Tiziana, Devecchi, Simona, Gianluca Castiello, Saracino, Antonio, Ghizzardi, Greta, Calorenne, Veronica, Andreea Alina Andronache, Laurenzia Ferraris, Simona Devecchi, Greta Ghizzardi, Magon, Arianna, Veronica Calorenne, Caruso, Rosario, Ferraris, Laurenzia, Caravella, Giuseppe   +23 more
core   +1 more source

Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment

Parasite, 2021
Acanthamoeba spp. are free-living parasites that can cause severe infections such as granulomatous amoebic encephalitis (GAE) and amoebic keratitis (AK). Polyhexamethylene biguanide (PHMB) is a topical application for AK treatment.
Huang Jian-Ming, Ko Pin-Ju, Huang Chao-Li, Wen Po-Wei, Chen Chun-Hsien, Shih Min-Hsiu, Lin Wei-Chen, Huang Fu-Chin   +7 more
doaj   +1 more source

Rapid, simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection

Journal of Pharmaceutical Analysis, 2013
A rapid and simple method for the determination of polyhexamethylene biguanide (polyhexanide, PHMB) in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection (HPLC–DAD) was ...
Markus Küsters, Sören Beyer, Stephan Kutscher, Harald Schlesinger, Michael Gerhartz   +4 more
doaj   +1 more source

Microsporidial stromal keratitis in an immunocompromised patient: Successful management with medical therapy

Indian Journal of Ophthalmology, 2020
Microsporidial stromal keratitis is refractory to topical drugs and is classically described in immunocompetent hosts. A 55-year-old patient with renal transplant and oral immunosuppressants, presented with a 15-day history of redness, pain, and ...
Amanjot Kaur, Srikant K Sahu, Sanchita Mitra, Sujata Das   +3 more
doaj   +1 more source

Determination of polyhexamethylene biguanide hydrochloride

Reviews in Analytical Chemistry, 2014
Polyhexamethylene biguanide hydrochloride (PHMB-HCl) is widely used as a disinfectant in personal care products such as cosmetics and toiletries and as a sanitizer in swimming pools. PHMB-HCl possesses marked characteristics of cationic polyelectrolytes.
Masadome Takashi, Hattori Toshiaki
doaj   +1 more source

Polyvinyl Alcohol/Chitosan/Polyhexamethylene Biguanide Phase Separation System: A Potential Topical Antibacterial Formulation with Enhanced Antimicrobial Effect

Molecules, 2020
An aqueous polyvinyl alcohol (PVA)/chitosan (CHT)/polyhexamethylene biguanide (PHMB) blends (PVA/CHT/PHMB blends) has been developed as a potential low dose topical antibacterial formulation with enhanced antimicrobial effect.
Yunzhou Ni, Zhixiang Qian, Yu Yin, Weien Yuan, Fei Wu, Tuo Jin   +5 more
doaj   +1 more source

Raman microspectroscopy analysis in the treatment of acanthamoeba keratitis. [PDF]

PLoS ONE, 2013
Acanthamoeba keratitis is a rare but serious corneal disease, often observed in contact lens wearers. Clinical treatment of infected patients frequently involves the use of polyhexamethylene biguanide (PHMB), a polymer used as a disinfectant and ...
Giulia Rusciano, Paola Capriglione, Giuseppe Pesce, Salvatore Del Prete, Gilda Cennamo, David Di Cave, Luciano Cerulli, Antonio Sasso   +7 more
doaj   +1 more source

Safety and tolerability of topical polyhexamethylene biguanide (PHMB): a randomised clinical trial in healthy adult volunteers [PDF]

, 2021
Background and Aims: Polyhexamethyl biguanide (PHMB), a widely used topical treatment for Acanthamoeba keratitis (AK), is unlicensed with no formal safety assessment. This study evaluated its safety and tolerability. Methods: A prospective, randomised,
Asero, A, Sallet, G, Rottey, S, Minassian, D, Dart, J, van der Meulen, I, Overweel, J, Papa, V   +7 more
core   +1 more source

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB). [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vaccine against CL, and the chemotherapy options
Rebuma Firdessa, Liam Good, Maria Cecilia Amstalden, Kantaraja Chindera, Nor Fadhilah Kamaruzzaman, Martina Schultheis, Bianca Röger, Nina Hecht, Tobias A Oelschlaeger, Lorenz Meinel, Tessa Lühmann, Heidrun Moll   +11 more
doaj   +1 more source

Biodegradability of end-groups of the biocide polyhexamethylene biguanide (PHMB) assessed using model compounds

Journal of Industrial Microbiology & Biotechnology, 2006
Polyhexamethylene biguanide (PHMB), a biocide used in a wide variety of disinfection and preservation applications, is a polydisperse mixture in which the end-groups may be any combination of amine, guanidine and cyanoguanidine. Using PHMB model compounds (1,6-diaminohexane; 1,6-diguanidinohexane; 1,6-di(cyanoguanidino)hexane; 4-guanidinobutyric acid),
Leon P, O'Malley, Andrew N, Collins, Graham F, White   +2 more
openaire   +2 more sources