Results 201 to 210 of about 39,295 (245)
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]
Angewandte Chemie - International Edition, 2018 AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Roy A Meoded +2 more
exaly +6 more sources
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase [PDF]
Chemistry and Biology, 2001 Background: Modular polyketide synthases catalyse the biosynthesis of medically useful natural products by stepwise chain assembly, with each module of enzyme activities catalysing a separate cycle of polyketide chain extension.
Philip J Sidebottom +2 more
exaly +2 more sources
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2016This review discusses the biosynthesis of natural products that are generated bytrans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides.
Helfrich Eric J N, Piel Jörn
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2016
Polyketides are a fascinating class of natural products with highly diverse, often complex structures combined with a likewise impressive breath of strong and selective biological activities. This chapter discusses the logic of biosynthetic polyketide assembly.
Schaefers, Françoise +7 more
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Polyketides are a fascinating class of natural products with highly diverse, often complex structures combined with a likewise impressive breath of strong and selective biological activities. This chapter discusses the logic of biosynthetic polyketide assembly.
Schaefers, Françoise +7 more
openaire +3 more sources
Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2010This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
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Engineering of modular polyketide synthases to produce novel polyketides
Current Opinion in Biotechnology, 1998Polyketides are important natural products produced by Actinomycetes and other organisms via the polymerization of coenzyme A-activated carboxylic acids. Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic process using a dedicated 'module' for each polymerization reaction, which specifies the unit to be ...
, Carreras, , Santi
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Biosynthesis of polyketides by trans-AT polyketide synthases in Burkholderiales
Critical Reviews in Microbiology, 2019Widely used as drugs and agrochemicals, polyketides are a family of bioactive natural products, with diverse structures and functions. Polyketides are produced by megaenzymes termed as polyketide synthases (PKSs). PKS biosynthetic pathways are divided into the cis-AT PKSs and trans-AT PKSs; a division based mainly on the absence of an acyltransferase ...
Hanna, Chen +10 more
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Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Product template (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for controlling the aldol cyclizations of poly-β-ketone intermediates during polyketide biosynthesis.
Jay D Keasling +2 more
exaly +3 more sources
Towards engineered polyketides
Expert Opinion on Investigational Drugs, 1998Rapid advances have been made over the past 10 years in the identification of the biosynthetic machinery that carries out the biosynthesis of polyketide natural products. Many such compounds are used in various therapeutic areas, including antibacterials, anticancer, antifungals and cholesterol lowering.
J, Staunton, B, Wilkinson
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