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Polyketide pesticides from actinomycetes
Current Opinion in Biotechnology, 2021Natural product derived pesticides have increased in popularity worldwide because of their high efficacy, eco-friendly nature and favorable safety profile. The development of polyketide pesticides from actinomycetes reflects this increase in popularity in the past decades.
Shanshan, Li +7 more
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Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants
Bioorganic & Medicinal Chemistry Letters, 1999Compounds produced by the polyketide ketoreductase deficient Streptomyces mutants HO61 and P67 are described. The structures of the compounds indicate that ketoreductase activity is required for correct condensation of the polyketide chain in the biosynthesis of aromatic polyketides.
T, Kunnari +5 more
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1994
This chapter discusses the condensation of acetyl-SCoA with malonyl-SCoA units that gives rise to numerous aromatic compounds, many of which have meta-disposition of hydroxyl groups. It mentions products of the polyketide pathway and its typical examples, such as 6-methylsalicyclicacid, antifungal compound griseofulvin, mycotoxins patulin, and ...
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This chapter discusses the condensation of acetyl-SCoA with malonyl-SCoA units that gives rise to numerous aromatic compounds, many of which have meta-disposition of hydroxyl groups. It mentions products of the polyketide pathway and its typical examples, such as 6-methylsalicyclicacid, antifungal compound griseofulvin, mycotoxins patulin, and ...
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2010This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
Nature, 1995Modular polyketide synthases (PKSs) are complex multi-enzyme proteins that catalyse the bacterial biosynthesis of many pharmaceutically useful polyketides. The PKSs are organized into a series of modules, each containing the active catalytic sites required for one step in the synthesis process.
R, Pieper, G, Luo, D E, Cane, C, Khosla
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