Results 131 to 140 of about 337,291 (404)

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

Oxidative Medicine and Cellular Longevity, 2016
Oxidative stress is viewed as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms, which can lead to chronic inflammation.
Tarique Hussain, B. Tan, Yulong Yin, F. Blachier, M. Tossou, Najma Rahu   +5 more
semanticscholar   +1 more source

Polyphenols and Flavones from Agricultural Products and Their Health-Promoting Properties

Polyphenol and flavone compounds are abundant in fruits, vegetables and lots of other agricultural products (such as blueberries, cherries, grapes, onions, beans, cabbage, rice, sorghum, maize, etc.) and have received considerable attention for their ...

core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Polyphenol-Rich Extracts of Xylopia and Aframomum Species Show Metabolic Benefits by Lowering Hepatic Lipid Accumulation in Diet-Induced Obese Mice

, 2022
Achille Parfait Atchan Nwakiban, Shilpa Talkad Shivashankara, Stefano Piazza, Armelle Deutou Tchamgoué, Giangiacomo Beretta, Mario Dell’Agli, Paolo Magni, Gabriel A. Agbor, Jules‐Roger Kuiate, Uma V. Manjappara   +9 more
openalex   +1 more source

Characterization of polyphenols in leaves of four desiccation tolerant plant families

, 2005
Includes bibliographical references.Polyphenols in plants are known to act as antioxidants, antimicrobials, antifungal, photoreceptors, visual attractors and as light screens.
Dzobo, Kevin
core  

GREEN TEA POLYPHENOLS AFFECT INVASIVENESS OF HUMAN GASTRIC MKN-28 CELLS BY INHIBITION OF LPS OR TNF-ΑLPHA INDUCED MATRIX METALLOPROTEINASE-9/2

, 2017
Green tea polyphenols have been identified as molecules responsible for the beneficial effects showed by the green tea against oxidative stress and cancer risk.
D'ANGELO, Stefania, NASSO, ROSARITA, DI DONATO, Paola, ARCONE, Rosaria, MASULLO, Mariorosario   +4 more
core   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

Molecules, 2019
Polyphenols are categorized as plant secondary metabolites, and they have attracted much attention in relation to human health and the prevention of chronic diseases.
K. Kawabata, Yasukiyo Yoshioka, J. Terao
semanticscholar   +1 more source