Results 41 to 50 of about 1,853 (164)

Polyreactive antibodies in CLL correlate with the level of immunoglobulins not the number of B lymphocytes [PDF]

Leukemia & Lymphoma, 2018
Polyreactive antibodies are a major part of natural antibody repertoire and can react with different types of antigens both from the host (e.g.
Sreenivasulu Gunti, Sarah E.M. Herman, Raju V.S.R.K. Gottumukkala, Ying Xiong, Clare Sun, Gilberto N. Carmona, Adrian Wiestner, Abner L. Notkins   +7 more
openaire   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, Volume 599, Issue 20, Page 2896-2910, October 2025.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Strategic addition of an N-linked glycan to a monoclonal antibody improves its HIV-1-neutralizing activity [PDF]

, 2014
Ibalizumab is a humanized monoclonal antibody that binds human CD4—a key receptor for HIV—and blocks HIV-1 infection. However, HIV-1 strains with mutations resulting in loss of an N-linked glycan from the V5 loop of the envelope protein gp120 are ...
Franco, David, Ho, David D., Oren, Deena A., Seaman, Michael S., Song, Ruijiang   +4 more
core   +1 more source

Protective Microbiota: From Localized to Long-Reaching Co-Immunity [PDF]

, 2017
Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance ...
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core   +4 more sources

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang   +9 more
wiley   +1 more source

Thymflammation: The Role of a Constitutively Active Inflammatory Network and “Ectopic” Cell Types in the Thymus in the Induction of T Cell Tolerance and Beyond

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT The thymus exhibits constitutive activation of nearly all major inflammatory pathways, including sterile MyD88‐dependent signaling and interferon production by mTECs, the presence of cellular and molecular components of type 1, type 2, and type 3 responses, as well as sustained B cell activation. The reasons for the existence of such a complex
Taras Kreslavsky
wiley   +1 more source

HLA Class Ia and Ib Polyreactive Anti-HLA-E IgG2a Monoclonal Antibodies (TFL-006 and TFL-007) Suppress Anti-HLA IgG Production by CD19+ B Cells and Proliferation of CD4+ T Cells While Upregulating Tregs [PDF]

, 2017
The anti-HLA-E IgG2a mAbs, TFL-006 and TFL-007, reacted with all HLA-I antigens, similar to the therapeutic preparations of IVIg. Indeed, IVIg lost its HLA reactivity, when its HLA-E reactivity was adsorbed out.
Mepur H. Ravindranath
core   +2 more sources

Immunresponser i atlantisk laks (Salmo salar) etter vaksinasjon mot og smitte med Salmonid alphavirus [PDF]

, 2021
Norway has perfect conditions for Atlantic salmon (Salmo salar) production and is one of the largest producers of salmon for food consumption worldwide, but rearing fish at high densities also means that infectious disease agents can easily transmit ...
Bakke, Anne Flore
core  

Polyreactive antibodies in multidonor-derived immunoglobulin G: Theory and conclusions drawn from experiments

Immunobiology, 2010
Multidonor-derived (md) preparations of IgG antibodies, agents of therapeutic potential, contain molecules interacting at clonal concentrations (concns) and with affinities recently estimated to cover a considerable range. Here we demonstrate that polyreactivity of the monomeric molecules represents the essential driving force of formation of the main ...
Peter, Gronski, Christian, Schridde, Horst-Dieter, Försterling   +2 more
openaire   +2 more sources

Treatment strategy for systemic lupus erythematosus using belimumab as indicated by multi‐omics analysis

Rheumatology &Autoimmunity, Volume 5, Issue 2, Page 81-87, June 2025.
Recent multi‐omics studies have demonstrated that belimumab specifically targets naïve B cells and a subset of memory B cells. This observation is consistent with belimumab's established efficacy and safety profile. Abstract Belimumab is an antibody targeting the cytokine B‐cell activating factor (BAFF), which is crucial for B cell differentiation, and
Keishi Fujio, Toshiyuki Ushijima, Tatsuki Abe, Tomohisa Okamura, Sang‐Cheol Bae, Yumi Tsuchida   +5 more
wiley   +1 more source