Results 131 to 140 of about 516,407 (164)

Functional 20S Proteasomes in Retroviruses: Evidence in Favor. [PDF]

Int J Mol Sci
Morozov V, Morozov A, Karpov VL.
europepmc   +1 more source

Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies. [PDF]

Front Immunol
Stelcer E, Wozniak A, Magner D, Zeyland J.   +3 more
europepmc   +1 more source

Infectious Diseases and Clinical Xenotransplantation. [PDF]

Emerg Infect Dis
Fishman JA, Mueller NJ.
europepmc   +1 more source

Application of Methods Detecting Xenotransplantation-Relevant Viruses for Screening German Slaughterhouse Pigs. [PDF]

Viruses
Jhelum H, Kaufer B, Denner J.
europepmc   +1 more source

Xenotransplantation: Current Understanding of the Mechanism of Immune-Mediated Injury. [PDF]

J Am Soc Nephrol
Tatapudi VS, Mattoo A, Schiff T, Mehta SA, Skolnik EY, Montgomery RA.   +5 more
europepmc   +1 more source

Porcine endogenous retroviruses (PERVs): adaptation to human cells and attempts to infect small animals and non-human primates.

Annals of transplantation, 2002
J, Denner, V, Specke, J, Schwendemann, S J, Tacke   +3 more
openaire   +1 more source

Expression of porcine endogenous retroviruses (PERV) in different organs of a pig [PDF]

Virology, 2012
Porcine endogenous retroviruses (PERVs) represent a particular risk for xenotransplantation using pig cells, tissues or organs. PERVs are integrated in the genome of all pig strains and can be released as particles that infect human cells. We performed for the first time a systematic analysis of PERV expression in different organs of a miniature pig ...
Joachim Denner, Iris Bittmann
exaly   +4 more sources

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The origin of porcine endogenous retroviruses (PERVs)

Archives of Virology, 2021
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and they produce viral particles that are able to infect human cells and therefore pose a special risk for xenotransplantation. In contrast to other pig microorganisms that also pose a risk, such as porcine cytomegalovirus and hepatitis E virus, PERVs cannot be eliminated
openaire   +2 more sources

Inhibition of porcine endogenous retroviruses (PERVs) in primary porcine cells by RNA interference using lentiviral vectors

Archives of Virology, 2006
A potential risk in pig-to-human xenotransplantation is the transmission of PERVs to human recipients. Here we show for the first time the inhibition of PERV expression in primary porcine cells by RNA interference using lentiviral vectors. Cells were transduced with lentiviral vectors coding for short hairpin (sh) RNAs directed against PERV.
B, Dieckhoff, A, Karlas, A, Hofmann, W A, Kues, B, Petersen, A, Pfeifer, H, Niemann, R, Kurth, J, Denner   +8 more
openaire   +2 more sources

Porcine Endogenous Retroviruses in Xenotransplantation

2011
Organ transplant is an effective therapy for end-stage organ failure but is currently limited by the shortage of human donors. The possibility that animals could provide an alternative source of donor organs and cells or tissue, a process known as xenotransplantation, has stimulated much debate, with general agreement that the pig is the most promising
Scobie, Linda, Garkavenko, Olga
openaire   +1 more source