Results 151 to 160 of about 1,247 (177)

CRISPR Technology Acts as a Dual-Purpose Tool in Pig Breeding: Enhancing Both Agricultural Productivity and Biomedical Applications. [PDF]

Biomolecules
Fu B, Ma H, Huo X, Zhu Y, Liu D.
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The origin of porcine endogenous retroviruses (PERVs)

Archives of Virology, 2021
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and they produce viral particles that are able to infect human cells and therefore pose a special risk for xenotransplantation. In contrast to other pig microorganisms that also pose a risk, such as porcine cytomegalovirus and hepatitis E virus, PERVs cannot be eliminated
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Inhibition of porcine endogenous retroviruses (PERVs) in primary porcine cells by RNA interference using lentiviral vectors

Archives of Virology, 2006
A potential risk in pig-to-human xenotransplantation is the transmission of PERVs to human recipients. Here we show for the first time the inhibition of PERV expression in primary porcine cells by RNA interference using lentiviral vectors. Cells were transduced with lentiviral vectors coding for short hairpin (sh) RNAs directed against PERV.
B, Dieckhoff, A, Karlas, A, Hofmann, W A, Kues, B, Petersen, A, Pfeifer, H, Niemann, R, Kurth, J, Denner   +8 more
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Phylogenetic relationship of porcine endogenous retrovirus (PERV) in Chinese pigs with some type C retroviruses

Virus Research, 2004
PCR amplification of proviral DNA extracted from peripheral blood lymphocytes of three Chinese pigs (Banna minipig inbreed (BMI), Wu-Zhi-Shan pig (WZSP) and Neijiang pig (NJP)), using primers corresponding to highly conserved regions of reverse transcriptase (RT) of pol gene and nucleocapsid sequence of gag gene.
Zhang, Li, Yu, Ping, Li, Shengfu, Bu, Hong, Li, Youping, Zeng, Yangzhi, Cheng, Jingqiu   +6 more
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Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?

Archives of Virology, 2008
The zoonotic transmissions from non‐human primates of the human immunodeficiency virus (HIV‐1) that initiated the AIDS pandemic and the spread of many emerging infectious diseases teaches us that there is a need for carefully consider the potential risks associated with xenotransplantation. Whereas known viruses can easily be eliminated from donor pigs
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Porcine endogenous retroviruses (PERVs): Generation of specific antibodies, development of an immunoperoxidase
assay (IPA) and inhibition by AZT

Xenotransplantation, 2001
Abstract: Xenotransplantation may be associated with the risk of transmission of microorganisms. In particular, the porcine endogenous retroviruses (PERV) have raised concerns as in vitro experiments show susceptibility of human cells for PERV infection.
O, Stephan, J, Schwendemann, V, Specke, S J, Tacke, K, Boller, J, Denner   +5 more
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Porcine Endogenous Retroviruses in Xenotransplantation

2011
Organ transplant is an effective therapy for end-stage organ failure but is currently limited by the shortage of human donors. The possibility that animals could provide an alternative source of donor organs and cells or tissue, a process known as xenotransplantation, has stimulated much debate, with general agreement that the pig is the most promising
Scobie, Linda, Garkavenko, Olga
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Productive infection of a mink cell line with porcine endogenous retroviruses (PERVs) but lack of transmission to minks in vivo

Archives of Virology, 2002
Porcine endogenous retroviruses (PERVs) are considered a special risk for xenotransplantation because they are an integral part of the porcine genome and are able to infect cells of numerous species including humans in vitro. Among these cells, the mink lung epithelial cell line Mv1Lu could be productively infected with PERV.
V, Specke, R, Plesker, C, Coulibaly, K, Boller, J, Denner   +4 more
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[Porcine endogenous retroviruses (PERV): in vitro artifact or a big problem for xenotransplantation?].

DTW. Deutsche tierarztliche Wochenschrift, 1999
The pig is the favorized donor species for clinical xenotransplantation. However, PATIENCE et al. could show, that porcine endogenous retroviruses (PERV), released by a porcine kidney cell line, are capable of infecting human cell lines in vitro. Based on this discovery there is an ongoing discussion concerning the risks of zoonosis combined with ...
U, Martin, G, Steinhoff
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Umbilical Cord Blood Stem Cells Induced into Myeloid, Erythroid, or Megakaryocytic Pathways Are Susceptible to Infection by Porcine Endogenous Retroviruses (PERV).

Blood, 2005
Abstract Susceptibility of human hematopoietic stem cells to infection with porcine endogenous retroviruses (PERV) is of prime importance in determining the feasibility and safety of transplanting pig organs into humans. Under the influence of lineage specific cytokines, umbilical cord blood stem cells were evaluated for their ...
Carolyn A. Wilson, Takele Argaw, Doris A. Morgan   +2 more
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